DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tak1 and Lrrk1

DIOPT Version :9

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_001178553.1 Gene:Lrrk1 / 308703 RGDID:1308000 Length:2013 Species:Rattus norvegicus


Alignment Length:752 Identity:163/752 - (21%)
Similarity:268/752 - (35%) Gaps:226/752 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 VGHGSYG-VVCKAVWRDKLVAVKEFF-----------------------ASAEQKDIEKEVKQLS 65
            :|.|..| |:.:|.::.:.||||.|.                       |.....|..:|...|.
  Rat  1248 LGQGGSGTVIYQAQYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLH 1312

  Fly    66 RVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPA--YSLAHAMSW--ARQCAEGLA 126
            .::||.|::|.|||.:...  ..:|.|..|||:..|....|.:  ..|.|.::.  |.|.|.|||
  Rat  1313 ALQHPCIVSLIGISIHPLC--FALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLA 1375

  Fly   127 YLHAMTPKPLIHRDVKPLNLLL----TNKGRNLKICDFGTVADKS--TMMTNNRGSAAWMAPEVF 185
            |||   .|.:|..|:|..|:|:    ..:..|:|:.|:| ::.:|  .......|:..:.|||:.
  Rat  1376 YLH---KKNIIFCDLKSDNILVWSLSVKELINIKLSDYG-ISRQSFHEGALGVEGTPGYQAPEIR 1436

  Fly   186 EGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPK-----RIEDL 245
            ....|.||.|:||:.:||:|:||.::|..|......:: |:.||.||.|  ..|:     |::.|
  Rat  1437 PRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVK-KLSKGIRPVL--GQPEEVQFYRLQAL 1498

  Fly   246 MTACWKTVPEDRPSMQYIVGVMHEIV---------------------KDYT-----GADKALEYT 284
            |..||.|.||.||....:|..|.:..                     ::||     |.:::..||
  Rat  1499 MMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSSFFSSQSQEYTVVFWDGKEESRNYT 1563

  Fly   285 FVNQ-------QIVT----------KESDGTVAAQPDS---LSSQEGELSPSS--TQLTPTTAAN 327
            .||.       |.:|          |.......|..|.   :.|.:| :.|.|  .|...|.|..
  Rat  1564 VVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWLATEDQKIYIYSLKG-MCPLSMPQQALDTPAVV 1627

  Fly   328 ANVNAIAISK--------------TTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAI 378
            ....|:.:.|              ....||...|...|.....:::.   |...|        .|
  Rat  1628 TCFLAVPVIKKNSFLVLAGLADGLVAVFSMARGTPKESCSYLCSHTA---NRSKF--------CI 1681

  Fly   379 PEEESNESRNDSFNLTSSAEATQRLETIRN----------GMILMACKPMEQLTLDVEANGFDLS 433
            |:|:|.:          :....:.:|.:.:          |::::.|     ..||:...   |.
  Rat  1682 PDEDSRQ----------NPYPVRAMEVVNSGSEVWYSNGPGLLIIDC-----AILDISRR---LE 1728

  Fly   434 PSESSSSSTN--AKSD--GRERLTVTDTKPVMMTTDLSNNNGGIHAHS----------------- 477
            |..:.|..|:  ..||  |.|.:...|.|          .|..:..||                 
  Rat  1729 PYAAPSVVTSLVCSSDCRGEETVWCLDDK----------GNSLVMYHSATYQLCARYFCGDPSPL 1783

  Fly   478 -----------NGLLSHANGWQARDEE--------------LQEQEHEQEI-----VNSLDVDVD 512
                       ...:.|....:..:||              :|...|:..:     |:|......
  Rat  1784 RDTFSVQPSVPESPIRHITTSKEPEEECIADVSIMYSEELGMQILTHQDSLTDYCSVSSYSSTPH 1848

  Fly   513 PDEDENDGTEQSL---------AEILDPELQPEPPI-PNDAESQLIYRD----HRHM-AKEYLSV 562
            ||.........||         |...||:...||.: |:..|..|...|    .:|: |.:.|:|
  Rat  1849 PDPKSPTSLPSSLTSYSSVPFSANYEDPDRLQEPSVTPDRTEHDLSPMDGETFSQHLQAVKVLAV 1913

  Fly   563 DTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKE 599
            ...::..:...|.:::.:::....|:..::..:|.:|
  Rat  1914 QDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARE 1950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 TyrKc 19..264 CDD:197581 84/277 (30%)
STKc_TAK1 25..275 CDD:270960 86/309 (28%)
Lrrk1NP_001178553.1 ANK 91..214 CDD:238125
ANK repeat 91..119 CDD:293786
Ank_2 126..221 CDD:289560
ANK repeat 156..186 CDD:293786
ANK repeat 188..218 CDD:293786
LRR_RI <273..464 CDD:238064
LRR <279..513 CDD:227223
leucine-rich repeat 281..303 CDD:275380
leucine-rich repeat 304..330 CDD:275380
leucine-rich repeat 331..381 CDD:275380
leucine-rich repeat 382..405 CDD:275380
leucine-rich repeat 406..451 CDD:275380
leucine-rich repeat 452..474 CDD:275380
leucine-rich repeat 475..498 CDD:275380
leucine-rich repeat 499..549 CDD:275380
leucine-rich repeat 550..572 CDD:275380
Gem1 635..>781 CDD:224025
P-loop_NTPase 639..821 CDD:304359
COR 844..1036 CDD:292713
S_TKc 1247..1511 CDD:214567 82/271 (30%)
STKc_LRRK1 1248..1523 CDD:270969 86/283 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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