DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Map3k10

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001382027.1	Gene:	Map3k10 / 308463	RGDID:	1308381	Length:	940	Species:	Rattus norvegicus

Alignment Length:	334	Identity:	107/334 - (32%)
Similarity:	168/334 - (50%)	Gaps:	55/334 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWRDKLVAVK--------EFFASAEQKDIEKEVKQLSRVKHP 70
            :.|.|:.|.|.:|.|.:|.|.:|:||.:.||||        :...:|||  :.:|.:....::||
  Rat    93 IPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQ--VRQEARLFGALQHP 155

  Fly    71 NIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKP 135
            |||||.|.........|:||:|.||:|...|.|:..|.:.|   ::||.|.|.|:.|||...|.|
  Rat   156 NIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVL---VNWAVQVARGMNYLHNDAPVP 217

  Fly   136 LIHRDVKPLNLLLTNKGRN-------LKICDFGTVAD--KSTMMTNNRGSAAWMAPEVFEGSKYT 191
            :||||:|.:|:|:.....|       |||.|||...:  |:|.| :..|:.|||||||...|.::
  Rat   218 IIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKM-SAAGTYAWMAPEVIRLSLFS 281

  Fly   192 EKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP-PLLTTCPKRIEDLMTACWKTVPE 255
            :..|::|:.::|||:|:.:.|::.|| |..:.:.:...:.. |:.:|||:....|:..||...|.
  Rat   282 KSSDVWSFGVLLWELLTGEVPYREID-ALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPH 345

  Fly   256 DRPSMQYIVGVM----------------HEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPD 304
            .||....|:..:                |.:.:|:     .||...:...:.|||.:
  Rat   346 GRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDW-----KLEIQHMFDDLRTKEKE-------- 397

  Fly   305 SLSSQEGEL 313
             |.|:|.||
  Rat   398 -LRSREEEL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	92/262 (35%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	93/283 (33%)
Map3k10	NP_001382027.1	Leucine-zipper 1	384..405		6/29 (21%)
		Leucine-zipper 2	419..440
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..599
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..658
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..916
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810