Protein Alignment Tak1 and Ripk1

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001100820.1
• Gene: Ripk1 / 306886
• RGDID: 1310158
• Length: 658
• Species: Rattus norvegicus
• Alignment Length: 682
• Identity: 154/682 - (22%)
• Similarity: 266/682 - (39%)
• Gaps: 146/682 - (21%)

  Fly     5 SLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDK-LVAVKEFFASAEQKD----IEKEVKQL 64
            |||.::.|..|..|   |:.:..|.:|.|.....|.. .|.:|:.:....:.:    :.:|.|.:
  Rat     6 SLDNIKMASDDLLE---RKDLDSGGFGKVSLCFHRTHGFVILKKVYTGPNRAEYNEALLEEGKMM 67

  Fly    65 SRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLH 129
            .|::|..::.|.||...:....|:||:.|.|:|.:.|  |.|.:..|:.......:..||:.|||
  Rat    68 HRLRHDRVVKLLGIIIEEGNYSLVMEYMEQGNLMHVL--KTKESVPLSVKGRIIVEIIEGMHYLH 130

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADK----------------STMMTNNRGSAA 178
               .:.:||:|:||.|:|: ::..::||.|.|..:.|                |::...|.|:..
  Rat   131 ---DEGVIHKDLKPENILV-DRDFHIKIADLGVASFKTWSKLTKEEHNKQREASSVTKKNGGTLY 191

  Fly   179 WMAPEVFE--GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP---PLLTTC 238
            :||||...  .:|.|||.|::|:|||||.:.:.|:|::.:.........|..|.||   .:|..|
  Rat   192 YMAPEHLTDINTKPTEKSDVYSFAIVLWAIFANKEPYENVICTEQFLVCINSGNRPNVEDILEFC 256

  Fly   239 PKRIEDLMTACWKTVPEDRPSM----------------QYIVGVMHEIVKDYTGADKALEYTF-V 286
            |:.|..||..||:|.|||||:.                :|:...:..:.|:|......|:..| :
  Rat   257 PREIISLMERCWQTNPEDRPTFFGIEKEFKPFYLSQFEEYVEEDVASLKKEYPSQSPVLKRMFSL 321

  Fly   287 NQQIVTKESDGTVAAQPDSLSSQEG-ELSP------SSTQLTPTTAANANVNAIAISKTTTSSMT 344
            ....|......:.:.||.||.|.:| .:.|      ||:...|......:|.|         .:.
  Rat   322 QHDCVPLPPSRSNSEQPGSLHSSQGLPMGPVEESWFSSSPEYPQEENERSVQA---------KLQ 377

  Fly   345 ENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNG 409
            |..|..:..|....  |..:.|......||    .||......:|.|       |.||:..
  Rat   378 EEASYHAFGIFAEK--QTKSQPRLNEAYNR----EEERKRRVSHDPF-------AQQRVHE---- 425

  Fly   410 MILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAK---SDGRERLTVTDTKPVMMTTDLSNNNG 471
                          :|::.|....|..|::|..||.   |....::.|    |:.       |||
  Rat   426 --------------NVKSAGAKGLPYPSTTSHGNAAHQLSGPASQIKV----PLW-------NNG 465

  Fly   472 GIHAHSNGLL--------SHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEI 528
            ..:.|..|..        |.:..:.|....:.|......|.....:.:.|.:|....|..:.:.:
  Rat   466 VYNHHGFGATGTGVWYGPSVSQSYNAYKTPVPETNLPGSIPTMPYISLAPPDDSIRCTIYNSSRV 530

  Fly   529 ---------LDPELQPEP---PIPNDAESQLIYRD------------HRHMAKEYLSVDTNLYYA 569
                     |.|..||..   .:.:.:..|.::.:            ..:|.|::.:....|.:.
  Rat   531 QIGNYNYMDLGPSSQPPTNTCKVESTSRHQAVFANTTSLTDKHLNPIRENMGKQWKNCARKLGFT 595

  Fly   570 QDFKDKLIVQMDRTE-REQKQELLRKMKDKEG 600
            :...|::....:|.. :|:..::|:|...:||
  Rat   596 ESQIDEIDHDYERDGLKEKVYQMLQKWLMREG 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	80/291 (27%)
Ripk1	NP_001100820.1	Protein Kinases, catalytic domain	23..290	CDD:473864	78/272 (29%)
		Death_RIP1	570..655	CDD:260048	10/58 (17%)