DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and Ripk4

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001100573.1	Gene:	Ripk4 / 304053	RGDID:	1311691	Length:	786	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	175/727 - (24%)
Similarity:	270/727 - (37%)	Gaps:	218/727 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DFSEITLREKVGHGSYGVVCK---AVWRDKLVAVK----EFFASAEQKDIEKEVKQLSRVKHPNI 72
            |..|....||||...:|.|.|   ..|:..| |:|    ......|:.::.:|.|::...|...|
  Rat    18 DAGEFAGWEKVGSDGFGQVYKVRHVHWKTWL-AIKCSPSLHVDDRERTELLEEAKKMEMAKFRYI 81

  Fly    73 IALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKP---AYSLAHAMSWARQCAEGLAYLHAMTPK 134
            :.::||.  |:...|:||:.|.|||...|..:..|   .:.:.|      :.|.|:.:||.|:|
  Rat    82 LPVYGIC--QEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVH------ETAVGMNFLHCMSP- 137

  Fly   135 PLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR--------GSAAWMAPE-VFEGSK- 189
            ||:|.|:||.|:|| :...::||.|||..  |...|:::.        |:.|::.|| :.|.|:
  Rat   138 PLLHLDLKPANILL-DAHYHVKISDFGLA--KCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRL 199

  Fly   190 YTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKR------IEDLMTA 248
            :..|.|::|:|||:|.||::|:||....|...|..|:.||.||.|...|..|      :..||..
  Rat   200 FDTKHDVYSFAIVIWGVLTQKKPFSDEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQR 264

  Fly   249 CWKTVPEDRPSMQYIVGVMHEI-------VKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSL 306
            ||...|:.||:.|.|.....::       |||                         :|.:|...
  Rat   265 CWHADPQVRPTFQEITSETEDLCEKPDEEVKD-------------------------LAHEPGEK 304

  Fly   307 SSQE--GELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFY 369
            ||.|  .|..|.|::|...:|...:         ...|::|..|...|.|:.|..|
  Rat   305 SSPEPRSEARPESSRLKRASAPPFD---------NDCSLSELLSQLDSGISQTLEG--------- 351

  Fly   370 MVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSP 434
                     |||.|..|.......:||.   :||..:.:.....:.:....|:.:.||:..||.|
  Rat   352 ---------PEELSRSSSECKLPSSSSG---KRLSGVSSVDSAFSSRGSLSLSFEREASTGDLGP 404

  Fly   435 SESS---------SSSTN------------------------AKSDGRER----LTVTDTKPVMM 462
            ::..         |..||                        |...|:|.    |.:.:..|
  Rat   405 TDIQKKKLVDAIVSGDTNKLMKILQPQDVDLVLDSSASLLHLAVEAGQEECVKWLLLNNANP--- 466

  Fly   463 TTDLSNNNGGIHAH------SNG----LLSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDE 517
              :|:|..|....|      ..|    ||:......|:||:.....|..               .
  Rat   467 --NLTNKKGSTPLHMAVERRGRGIVELLLARKTSVNAKDEDQWTALHFA---------------A 514

  Fly   518 NDGTEQSLAEILDPELQPEPPIPNDAESQLIY--RDHRHMAKEYLSVDTNLYYAQDFKDKLIVQM 580
            .:|.|.|...:|:         .|.:.:::.:  |...|:|            .|..::.::
  Rat   515 QNGDEASTRLLLE---------KNASVNEVDFEGRTPMHVA------------CQHGQENIV--- 555

  Fly   581 DRTEREQKQELLRKMKDKEGLQSLYNNLQQQYASRQLAAGHHP-------QPHPHPHPNQLQHPH 638
             ||       |||:..| .|||.....|...||:.|   ||.|       ||....:...|.
  Rat   556 -RT-------LLRRGVD-VGLQGKDAWLPLHYAAWQ---GHLPIVKLLAKQPGVSVNAQTLD--- 605

  Fly   639 SHPPMHFLQDEG 650
            ...|:|.....|
  Rat   606 GRTPLHLAAQRG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	87/270 (32%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	89/282 (32%)
Ripk4	NP_001100573.1	STKc_RIP4_like	25..290	CDD:270927	88/277 (32%)
		TyrKc	26..279	CDD:197581	87/265 (33%)
		ANK repeat	442..470	CDD:293786	6/32 (19%)
		Ank_2	444..536	CDD:289560	21/120 (18%)
		ANK	471..591	CDD:238125	34/170 (20%)
		ANK repeat	473..503	CDD:293786	6/29 (21%)
		ANK repeat	505..536	CDD:293786	6/54 (11%)
		ANK repeat	538..569	CDD:293786	12/54 (22%)
		Ank_2	544..634	CDD:289560	25/104 (24%)
		ANK repeat	571..602	CDD:293786	9/33 (27%)
		ANK	600..725	CDD:238125	4/21 (19%)
		ANK repeat	605..636	CDD:293786	3/16 (19%)
		Ank_2	610..701	CDD:289560	2/8 (25%)
		ANK repeat	638..669	CDD:293786
		ANK repeat	671..701	CDD:293786
		Ank_2	676..766	CDD:289560
		ANK	731..>766	CDD:238125
		ANK repeat	736..766	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810