Protein Alignment Tak1 and Map3k13

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001014000.2
• Gene: Map3k13 / 303823
• RGDID: 1561227
• Length: 958
• Species: Rattus norvegicus
• Alignment Length: 769
• Identity: 183/769 - (23%)
• Similarity: 290/769 - (37%)
• Gaps: 228/769 - (29%)

  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGI 78
            |.|.||:..:.:|.|:.|.|....:|.:.||:|:.   .||.  |.::|.|.::|||||||..|:
  Rat   163 VPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKV---REQN--ETDIKHLRKLKHPNIIAFKGV 222

  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHG--KVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDV 141
            .:......:|||:...|.|:..|..  |:.|..    .:.|:...|.|:.|||.   ..:||||:
  Rat   223 CTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRL----LVDWSTGIASGMNYLHL---HKIIHRDL 280

  Fly   142 KPLNLLLTNKGRNLKICDFGT---VADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVL 203
            |..|:|:|:... :||.||||   ::||||.| :..|:.|||||||......:||.||:|:.:||
  Rat   281 KSPNVLVTHTDA-VKISDFGTSKELSDKSTKM-SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL 343

  Fly   204 WEVLSRKQPFKGIDNAYTIQWKIYKGE-RPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM 267
            ||:|:.:.|:|.:|:: .|.|.:.... ..|:.:|||...:.||...|::.|.:|||.:..  :|
  Rat   344 WELLTGEIPYKDVDSS-AIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQT--LM 405

  Fly   268 HEIVKDYTGAD--KALEYTFVNQQIVTKE----------SDGTVAAQPD-------------SLS 307
            |   .|...||  ...:.|:...|...:|          |:||...:.|             :|.
  Rat   406 H---LDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALD 467

  Fly   308 SQEG-------------ELSPSSTQLT-----------------PTTAANANVNAI----AISK- 337
            .:|.             |||....||.                 |.|.....|..|    |:.|
  Rat   468 IREHYERKLERANNLYMELSAIMLQLEMREKELLKREQAVEKKYPGTYKRHPVRPIIHPNAMEKL 532

  Fly   338 -------------TTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVT----NRWDAIPEEESNE 385
                         |....:..:....|::..||.| .|..:|  .|.|    :|:.:.|......
  Rat   533 MKRKVVSHKAGVQTKRPDLLRSEGIPSTEAVPTAS-PLSGSP--KMSTGSSRSRYRSKPRHRRGN 594

  Fly   386 SRNDSFNLTSSAEATQRLETIRNGMILM----ACKPMEQLTLDVEANGFDLSPSESSSSSTNAKS 446
            ||....:..:..:.....|...:...|.    .|....|..|..:    .:.|....|......:
  Rat   595 SRGSHSDFAAILKTQPAQENSPHPTYLQHTQAQCPSAYQHNLPQQ----QVPPPLPQSRHPRLNA 655

  Fly   447 DGRERLTVTDT-----KPVMMTTDLSNNNGGIHAH------SNGLLS---HANGWQARDEEL-QE 496
            .|::..|..:.     ....:.:.|||     ||.      |..|:|   .|:.|  |:.|| |:
  Rat   656 HGQDIATCANNLRYFGPAAALRSPLSN-----HAQRQMPGSSPDLISTAMAADCW--RNSELDQD 713

  Fly   497 Q--------------------EHEQEIVNSLDVDV------DPDEDEN----------------- 518
            |                    ||.    .||||..      .||...:
  Rat   714 QVGPWGCCQAEPYDPCFQCRPEHS----GSLDVPTTEPVGRSPDPSSSPAHNPLSGNAQGSERTE 774

  Fly   519 ----DGTEQSLAEILDPELQPEPPIP------------NDAESQLIY----RDHRHMAKEYLSVD 563
                :|.:..::....|.|.|:.|.|            .:.:|::.:    |.||.:: .|.|..
  Rat   775 ANGFNGCQSGISHQFTPPLLPQKPRPLQKSGDDSSEEEGEVDSEVEFPRRQRPHRCIS-SYQSYS 838

  Fly   564 TNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKD-KEGLQSLYNNLQQQYASRQ 616
            |  :.:::|                     .:.| :||..|.::|...:.|:|:
  Rat   839 T--FSSENF---------------------SVSDGEEGNTSDHSNSPDESANRR 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	91/255 (36%)
Map3k13	NP_001014000.2	STKc_MAP3K12_13	174..410	CDD:270961	91/255 (36%)