DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Tnni3k

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_861434.1	Gene:	Tnni3k / 295531	RGDID:	727908	Length:	835	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	113/409 - (27%)
Similarity:	192/409 - (46%)	Gaps:	56/409 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFAS--AEQKDIE---KEVKQLSRVKHPNI 72
            ::..|||...|.:|.||:|.|.|...|:|:||:|.:.|:  ..:.|::   :||..|.::.||.:
  Rat   457 HLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 521

  Fly    73 IALHGISSYQQATY-LIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPL 136
            :...|......:.: ::.::..||||.:.|| :.|....|...:..|...|:|:.|||::| :|:
  Rat   522 VQFVGACLDDPSQFAIVTQYISGGSLFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHSLT-QPI 584

  Fly   137 IHRDVKPLNLLLTNKGRNLKICDFGTVADKSTM----MTNNRGSAAWMAPEVF-EGSKYTEKCDI 196
            ||||:...|:||...|..: :.|||......::    ||...|:..||||||| :.::||.|.|:
  Rat   585 IHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADV 648

  Fly   197 FSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQ 261
            ||:::.|||:|:.:.||..:..|.......|...|||:..:.||.|..|:...|...||.||...
  Rat   649 FSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFS 713

  Fly   262 YIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQ---LTPT 323
            .:|              ..||....|.::::..|           |:..|.|||||:.   |:..
  Rat   714 EVV--------------SKLEECLCNVELMSPAS-----------SNSSGSLSPSSSSDCLLSRG 753

  Fly   324 TAANANVNAI--------AISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPE 380
            ....::|.|:        |::..:.:..:::..:.|:   |..|.:..|....|...:::..:.:
  Rat   754 GPGRSHVAALRSRFELEYALNARSYAGWSQSVGTHSN---PGLSLEEMNRSTQYSTVDKYGYVSD 815

  Fly   381 EES---NESRNDSFNLTSS 396
            ..|   ..||.|..|...|
  Rat   816 PMSLTHLHSRQDDSNFEDS 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	84/255 (33%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	83/260 (32%)
Tnni3k	NP_861434.1	ANK repeat	66..98	CDD:293786
		ANK 1	66..96
		Ank_2	71..164	CDD:289560
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		ANK 2	100..129
		ANK 3	133..162
		ANK repeat	134..164	CDD:293786
		Ank_2	138..232	CDD:289560
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		ANK 4	166..195
		ANK repeat	199..232	CDD:293786
		ANK 5	199..228
		ANK	229..360	CDD:238125
		ANK 6	234..263
		ANK repeat	234..262	CDD:293786
		Ank_4	238..287	CDD:290365
		ANK repeat	269..302	CDD:293786
		ANK 7	269..298
		Ank_2	274..369	CDD:289560
		ANK repeat	304..337	CDD:293786
		ANK 8	304..335
		ANK	334..>401	CDD:238125
		ANK repeat	339..369	CDD:293786
		ANK 9	339..368
		Ank_4	340..401	CDD:290365
		ANK 10	381..410
		TyrKc	463..719	CDD:197581	85/272 (31%)
		PKc_TNNI3K	469..722	CDD:270966	85/269 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810