DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tak1 and ABL2

DIOPT Version :10

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_009298.1 Gene:ABL2 / 27 HGNCID:77 Length:1182 Species:Homo sapiens


Alignment Length:826 Identity:180/826 - (21%)
Similarity:304/826 - (36%) Gaps:236/826 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SEITLREKVGHGSYGVVCKAVWR--DKLVAVKEFFA-SAEQKDIEKEVKQLSRVKHPNIIALHGI 78
            ::||::.|:|.|.||.|...||:  ...||||.... :.|.::..||...:..:||||::.|.|:
Human   286 TDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 350

  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKP 143
            .:.:...|::.|:...|:|.::|....:...:....:..|.|.:..:.||.   .|..||||:..
Human   351 CTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE---KKNFIHRDLAA 412

  Fly   144 LNLLLTNKGRN--LKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFS 198
            .|.|:   |.|  :|:.|||.    |.:||.:..:|        .|.|||....:.::.|.|:::
Human   413 RNCLV---GENHVVKVADFGL----SRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWA 470

  Fly   199 WAIVLWEVLS-RKQPFKGID--NAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPS- 259
            :.::|||:.: ...|:.|||  ..|.:..|.|:.|:|   ..||.::.:||.||||..|.|||| 
Human   471 FGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP---EGCPPKVYELMRACWKWSPADRPSF 532

  Fly   260 ---------MQYIVGVMHEIVKDY---TGADKALEY-----------TFVNQQIVTKES-DGTVA 300
                     |.:...:..|:.::.   ..:...:.|           ..:.:|:..||: :|...
Human   533 AETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQD 597

  Fly   301 AQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISK----TTTSSMTENTSST----------- 350
            |..:|.||    |:|...:     .|.|:..:.|:.:    .:.||:.|:...|           
Human   598 ATENSASS----LAPGFIR-----GAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRKGGFF 653

  Fly   351 -------SSDITPTNSG---QLDNNP-LFYMVTNRWDAIPEEESNESRNDSFNLTSSAEA----- 399
                   ::...|..|.   :::|.| ..|.:|..:.::    ::....|.|:.|.:.:.     
Human   654 SSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSV----ASLQHADGFSFTPAQQEANLVP 714

  Fly   400 --------------------------------------TQRLETIRNGMILMACKPMEQLTLDVE 426
                                                  |.||  |:..:.|.|.||...   |..
Human   715 PKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRL--IKKTLGLRAGKPTAS---DDT 774

  Fly   427 ANGFDLSPSESSSSSTNAKSDGRERLTVT----------DTKPVMMTTDLSNNNGGIHAHSNGLL 481
            :..|..|.|.||.||...:.|   |:.:|          ..:..:.|:.....|..   .:|.:|
Human   775 SKPFPRSNSTSSMSSGLPEQD---RMAMTLPRNCQRSKLQLERTVSTSSQPEENVD---RANDML 833

  Fly   482 ---SHANGWQARDE--------------------ELQEQEHEQEIVNSLDVDVDP-DEDENDGTE 522
               |..:...:|:.                    :|...|.:...|....|...| .:::|.|..
Human   834 PKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGAR 898

  Fly   523 QSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLS-------VDTNLY--YAQDFKDKLIV 578
            ..:|.:.:...||..|.|..| :.::...|.|.....:|       .|..|.  .:|..|.||:.
Human   899 LGMAGVPEDGEQPGWPSPAKA-APVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLS 962

  Fly   579 QMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQYASRQLAAGHHPQPHPHPHPNQLQHPH--SHP 641
            :...|....| :..|::|.|                        ..|.|.|....||||.  |.|
Human   963 EHQVTSSGDK-DRPRRVKPK------------------------CAPPPPPVMRLLQHPSICSDP 1002

  Fly   642 PMHFLQDEGCGLLPGSVC-----GGSE--------SVEEGWVVIPP 674
                 .:|...|..|...     ||.:        |.:.|..|:||
Human  1003 -----TEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPP 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 STKc_TAK1 25..275 CDD:270960 79/278 (28%)
ABL2NP_009298.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47
CAP 2..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80
SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189
PTKc_Abl 281..543 CDD:270645 80/269 (30%)
Kinase activation loop. /evidence=ECO:0000250 427..451 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..641 6/34 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..674 2/19 (11%)
Nuclear localization signal. /evidence=ECO:0000255 658..660 0/1 (0%)
F-actin-binding. /evidence=ECO:0000250 694..930 42/247 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..794 12/33 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 807..851 6/46 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1024 19/89 (21%)
F-actin-binding. /evidence=ECO:0000250 1020..1182 7/24 (29%)
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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