DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Ankk1

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001363880.1	Gene:	Ankk1 / 244859	MGIID:	3045301	Length:	746	Species:	Mus musculus

Alignment Length:	761	Identity:	178/761 - (23%)
Similarity:	291/761 - (38%)	Gaps:	228/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSEI-TLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGIS 79
            ||:: ..|.|.....|.:.|..       .:::...|:|...:.:|..::.::|..:|::::|:.
Mouse    45 FSKVFQARHKRWRTQYAIKCSP-------CLQKETTSSEVTCLFEEAVKMEKIKFQHIVSIYGVC 102

  Fly    80 SYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLA--------HAMSWARQCAEGLAYLHAMTPKPL 136
              :|...::|||...|||.     |..|.:||.        |..|.|      :.:||::.| ||
Mouse   103 --KQPLGIVMEFMASGSLE-----KTLPTHSLCWPLKLRIIHETSLA------MNFLHSIKP-PL 153

  Fly   137 IHRDVKPLNLLLTNKGRNLKICDFGTV--ADKSTM-----MTNNRGSAAWMAPEVF------EGS 188
            :|.|:||.|:||.| ..::||.|||..  .::||.     .:..||:.:::.||:|      .|.
Mouse   154 LHLDLKPGNILLDN-NMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGP 217

  Fly   189 KYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTC---PKRIE---DLMT 247
            :|    |::|:|||:||:|::|:|:.|: |..||..::..|.||.|....   |:.:.   :||.
Mouse   218 EY----DVYSFAIVIWEILTQKKPYAGL-NMMTIIIRVAAGMRPSLQDVSDEWPEEVHQMVNLMK 277

  Fly   248 ACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSS--QE 310
            .||...|:.||                         .|:|           ||.:.|.|.|  |.
Mouse   278 RCWDQDPKKRP-------------------------CFLN-----------VAVETDMLLSLFQS 306

  Fly   311 GELSPSSTQLTPTTAANANVN-AIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNR 374
            ....|....||...:...::: ...:||.....:.:  |:.|||                  :.:
Mouse   307 PMTDPGCEALTQKVSCKPSLSQPHKVSKEVNQEIAD--SAVSSD------------------SLK 351

  Fly   375 WDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTL----DVEANGFDLSPS 435
            |..        ..:||.:|.:|.....|:..:.   .|:|...:||:.|    ||:.:      .
Mouse   352 WIL--------QLSDSKSLVASDVYENRVTPLH---FLVAGGSLEQVRLLLSHDVDVD------C 399

  Fly   436 ESSSSSTNAKSDGRERLTVTDTKPVMMT--------TDLSNNNGGIHAH---SNG-------LLS 482
            :::|..|..      .:...|.:|.:..        |:|::.:|....|   .||       ||.
Mouse   400 QTASGYTPL------LIATQDQQPDLCALLLAHGADTNLADEDGWAPLHFAAQNGDDHTARLLLD 458

  Fly   483 HANGWQARDEE------LQEQ---EHEQEIVNSLDVDVDPDEDENDGT--------EQSLAEILD 530
            |.....||:.|      |..|   |:...::.|...|:.|.|.|....        ...|.::|.
Mouse   459 HGALVNAREHEGWTPLHLAAQNNFENVARLLVSRQADLSPHEAEGKTPLHVAAYFGHIGLVKLLS 523

  Fly   531 ---PELQPEPPIPNDAESQLIYRDHRHMAKEYLSVDT--NLYYAQDFKDKLIVQMDRT------- 583
               .||        ||:.:.: |...|:|.|...|..  :|.......|.|    |.:
Mouse   524 GQGAEL--------DAQQRNL-RTPLHLAVERGKVRAIQHLLKCGALPDAL----DHSGYSPLHI 575

  Fly   584 EREQKQELLRKMKDKEGLQSLYNNLQQQYASRQLAA--GHHPQPHPHPHPNQLQHPH-------- 638
            ...:.::|:.||..:.| .||....||.:....||.  ||....|      ||...|
Mouse   576 AAARGKDLIFKMLLRYG-ASLELRTQQGWTPLHLATYKGHLEIIH------QLAKSHVDLDALGS 633

  Fly   639 -SHPPMH---FLQDEGCGLLPGSVCGGSESVEE--GWVVIPPHHNA 678
             ...|:|   |..:||. :|....||.:.:..|  ||.   |.|.|
Mouse   634 MQWTPLHLAAFQGEEGV-MLALLQCGANPNAAEQSGWT---PLHLA 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	77/272 (28%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	75/276 (27%)
Ankk1	NP_001363880.1	PKc_like	37..305	CDD:389743	86/322 (27%)
		PHA02876	<364..>694	CDD:165207	78/351 (22%)
		ANK 1	370..399		8/37 (22%)
		ANK repeat	373..401	CDD:293786	7/36 (19%)
		ANK repeat	403..434	CDD:293786	6/36 (17%)
		ANK 2	403..432		5/34 (15%)
		ANK repeat	436..467	CDD:293786	8/30 (27%)
		ANK 3	436..465		7/28 (25%)
		ANK 4	469..498		6/28 (21%)
		ANK repeat	469..497	CDD:293786	6/27 (22%)
		ANK repeat	502..532	CDD:293786	6/37 (16%)
		ANK 5	502..531		5/36 (14%)
		ANK 6	535..564		6/29 (21%)
		ANK repeat	537..566	CDD:293786	8/32 (25%)
		ANK repeat	568..599	CDD:293786	6/31 (19%)
		ANK 7	568..597		6/29 (21%)
		ANK 8	601..630		9/34 (26%)
		ANK repeat	602..632	CDD:293786	8/35 (23%)
		ANK repeat	634..665	CDD:293786	8/31 (26%)
		ANK 9	634..663		8/29 (28%)
		ANK repeat	667..698	CDD:293786	5/12 (42%)
		ANK 10	667..696		5/12 (42%)
		Ank_2	672..>742	CDD:372319	2/4 (50%)
		ANK repeat	700..730	CDD:293786
		ANK 11	700..729
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810