Protein Alignment Tak1 and FES

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001996.1
• Gene: FES / 2242
• HGNCID: 3657
• Length: 822
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 83/275 - (30%)
• Similarity: 127/275 - (46%)
• Gaps: 27/275 - (9%)

  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWR--DKLVAVK---EFFASAEQKDIEKEVKQLSRVKHPNII 73
            ::..::.|.|::|.|::|.|.....|  :.|||||   |......:....:|.:.|.:..||||:
Human   556 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV 620

  Fly    74 ALHGISSYQQATYLIMEFAEGGSLHNFLHG-----KVKPAYSLAHAMSWARQCAEGLAYLHAMTP 133
            .|.|:.:.:|..|::||..:||....||..     :||.      .:......|.|:.||.:
Human   621 RLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKT------LLQMVGDAAAGMEYLES--- 676

  Fly   134 KPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGS-----AAWMAPEVFEGSKYTEK 193
            |..||||:...|.|:|.| ..|||.|||...:::..:....|.     ..|.|||.....:|:.:
Human   677 KCCIHRDLAARNCLVTEK-NVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSE 740

  Fly   194 CDIFSWAIVLWEVLS-RKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDR 257
            .|::|:.|:|||..| ...|:..:.|..|.:: :.||.|.|....||..:..||..||...|..|
Human   741 SDVWSFGILLWETFSLGASPYPNLSNQQTREF-VEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804

  Fly   258 PSMQYIVGVMHEIVK 272
            ||...|...:..|.|
Human   805 PSFSTIYQELQSIRK 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	81/264 (31%)
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300
		F-BAR_Fes	7..239	CDD:153369
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..421
		SH2_Fps_family	453..537	CDD:198224
		PTKc_Fes	564..815	CDD:270667	80/261 (31%)