Protein Alignment Tak1 and Ripk1

DIOPT Version :9

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001346926.1
• Gene: Ripk1 / 19766
• MGIID: 108212
• Length: 656
• Species: Mus musculus
• Alignment Length: 527
• Identity: 134/527 - (25%)
• Similarity: 214/527 - (40%)
• Gaps: 113/527 - (21%)

  Fly     5 SLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDK-LVAVKEFFAS---AEQKDI-EKEVKQL 64
            |||.::.|..|..|.|   .:..|.:|.|.....|.. .|.:|:.:..   ||..:: .:|.|.:
Mouse     6 SLDNIKMASSDLLEKT---DLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMM 67

  Fly    65 SRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLH 129
            .|::|..::.|.||...:....|:||:.|.|:|.:.|..::....||...:  ..:..||:.|||
Mouse    68 HRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRI--IVEAIEGMCYLH 130

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADK-----------------STMMTNNRGSA 177
               .|.:||:|:||.|:|: ::..::||.|.|..:.|                 ||...||.|:.
Mouse   131 ---DKGVIHKDLKPENILV-DRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTL 191

  Fly   178 AWMAPEVFE--GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP---PLLTT 237
            .:||||...  .:|.|||.|::|:.||||.:.::|:|::.:.........|..|.||   .:|..
Mouse   192 YYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEY 256

  Fly   238 CPKRIEDLMTACWKTVPEDRPSM----------------QYIVGVMHEIVKDYTGADKALEYTF- 285
            ||:.|..||..||:.:|||||:.                :|:...:..:.|:|......|:..|
Mouse   257 CPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFS 321

  Fly   286 VNQQIVTKESDGTVAAQPDSLSSQEG-ELSP------SSTQLTPTTAANANVNAIAISKTTTSSM 343
            :....|......:.:.||.||.|.:| ::.|      ||:...|....:.:|.|         .:
Mouse   322 LQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQA---------KL 377

  Fly   344 TENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRL-ETIR 407
            .|..|..:..|....  |....|......||    .||......:|.|       |.||. |.|:
Mouse   378 QEEASYHAFGIFAEK--QTKPQPRQNEAYNR----EEERKRRVSHDPF-------AQQRARENIK 429

  Fly   408 NGMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGG 472
            :                ..|.|       .|..||.::....::|:...|:.|.       |||.
Mouse   430 S----------------AGARG-------HSDPSTTSRGIAVQQLSWPATQTVW-------NNGL 464

  Fly   473 IHAHSNG 479
            .:.|..|
Mouse   465 YNQHGFG 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	82/287 (29%)
		STKc_TAK1	25..275	CDD:270960	82/292 (28%)
Ripk1	NP_001346926.1	PKc_like	23..291	CDD:419665	80/273 (29%)
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546	291..567		47/233 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..373		11/45 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..423		10/47 (21%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682	520..536
		Death_RIP1	568..653	CDD:260048

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810