DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and MLKL

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_689862.1	Gene:	MLKL / 197259	HGNCID:	26617	Length:	471	Species:	Homo sapiens

Alignment Length:	269	Identity:	70/269 - (26%)
Similarity:	121/269 - (44%)	Gaps:	35/269 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ITLREKVGHGSYGVVCKAVWRDKLVAVKEF------FASAEQKDIEKEVKQLSRVKHPNIIALHG 77
            |.|||    .....:.|..:....||:|.|      ..:..::...||:|.:.:.:.|||:.:.|
Human   207 ILLRE----NEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFG 267

  Fly    78 ISSYQQAT----YLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIH 138
            |...:..|    .::||:.|.|:|...|..  :...:|...|......|.||..|| .:..|.:|
Human   268 ICIDETVTPPQFSIVMEYCELGTLRELLDR--EKDLTLGKRMVLVLGAARGLYRLH-HSEAPELH 329

  Fly   139 RDVKPLNLLLTNKGRNLKICDF-----------GTVADKSTMMTNNRGSAAWMAPEVFEG--SKY 190
            ..::..|.|:| :|..:|:..|           ||..:|    |:...|.|:::|:..|.  .:|
Human   330 GKIRSSNFLVT-QGYQVKLAGFELRKTQTSMSLGTTREK----TDRVKSTAYLSPQELEDVFYQY 389

  Fly   191 TEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPE 255
            ..|.:|:|:.|||||:.:...||:|.::....:....|.::.||...||..:.:::..|....|.
Human   390 DVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPS 454

  Fly   256 DRPSMQYIV 264
            .|||:..|:
Human   455 VRPSVDEIL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	69/267 (26%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	66/263 (25%)
MLKL	NP_689862.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000269\|PubMed:29883610	1..149
		PHA02988	177..469	CDD:165291	70/269 (26%)
		PKc_like	215..466	CDD:304357	66/257 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900