DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and Ripk2

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_620402.1	Gene:	Ripk2 / 192656	MGIID:	1891456	Length:	539	Species:	Mus musculus

Alignment Length:	692	Identity:	154/692 - (22%)
Similarity:	253/692 - (36%)	Gaps:	207/692 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DALQAAY--VDFSEITLREKVGHGSYGVVCK---AVWRDKLVAVKEF-----FASAEQKDIEKEV 61
            ||:.:|.  :.:.::.....:..|:.|.|..   |.||.: ||||..     ...:|:.||.:|.
Mouse     4 DAICSALPPIPYHKLADLHYLSRGASGTVSSARHADWRVR-VAVKHLHIHTPLLDSERNDILREA 67

  Fly    62 KQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVK-PAYSLAHAMSWARQCAEGL 125
            :.|.:.:...|:.:.||.:..:...::.|:...|||:..||.|.: |..:.........:.|.|:
Mouse    68 EILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDIAWPLRFRILHEIALGV 132

  Fly   126 AYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR--------GSAAWMAP 182
            .|||.|.| ||:|.|:|..|:||.|: .::||.|||....:...::.:|        |:..:|.|
Mouse   133 NYLHNMNP-PLLHHDLKTQNILLDNE-FHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPP 195

  Fly   183 EVFE---GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPP-----LLTTCP 239
            |.:|   .|:.:.|.||:|:|:::||||||||||:.:.|...|.:.:.:|.||.     |....|
Mouse   196 ENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIP 260

  Fly   240 KR--IEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQ 302
            .|  :..|:.:.|...|::|||....:..:..:::.:.      :.||:...|..|:
Mouse   261 HRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFE------DITFLEAVIQLKK-------- 311

  Fly   303 PDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDIT---PTNSGQLDN 364
                                             :|..:||.|.:......|::   |.      |
Mouse   312 ---------------------------------AKIQSSSSTIHLCDKKMDLSLNIPA------N 337

  Fly   365 NPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANG 429
            :|            |:|||..|...|.|..|..                   |...|:...:...
Mouse   338 HP------------PQEESCGSSLLSRNTGSPG-------------------PSRSLSAPQDKGF 371

  Fly   430 FDLSPSESSSSST-----NAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSH------ 483
            ...:|.:.||...     |...||     :....|.....|...::..:...|..|:..
Mouse   372 LSGAPQDCSSLKAHHCPGNHSWDG-----IVSVPPGAAFCDRRASSCSLAVISPFLVEKGSERPP 431

  Fly   484 ---ANGW-QARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEILDPELQPEPPIPNDAE 544
               |..| |::.|.:..|..|..:..|||..:..|          |....|.||....|......
Mouse   432 IGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRD----------LIMKEDYELISTKPTRTSKV 486

  Fly   545 SQLIYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKE--GLQSLYNN 607
            .||:              ||:....::|. |::||              |:||.:  |||
Mouse   487 RQLL--------------DTSDIQGEEFA-KVVVQ--------------KLKDNKQLGLQ----- 517

  Fly   608 LQQQYASRQLAAGHHPQPHPHPHPNQLQHPHSHPPMHFLQDE 649
                               |:|....|.   ..||.:|.|::
Mouse   518 -------------------PYPEVPVLS---KAPPSNFPQNK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	83/271 (31%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	83/276 (30%)
Ripk2	NP_620402.1	STKc_RIP2	20..303	CDD:270928	84/291 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..368		13/69 (19%)
		CARD_RIP2_CARD3	437..522	CDD:176764	30/147 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..539		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810