DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Y105C5A.24

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_502888.2	Gene:	Y105C5A.24 / 190882	WormBaseID:	WBGene00013643	Length:	478	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	122/463 - (26%)
Similarity:	199/463 - (42%)	Gaps:	82/463 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VGHGSYGVVCKAVWRD------KLVAVKEFFASAEQKDI-EKEVKQLSRVK-HPNIIALHGI-SS 80
            :|.|::|||.|..:|.      :..|:|  :|||....| ::|.|.:..:: |.|||.::|: .|
Worm    49 LGKGTFGVVEKTKYRKTRDDTYRPAAIK--YASATHLSILKREAKHMWNLRNHVNIIKIYGMYES 111

  Fly    81 YQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLN 145
            ::....|:||:.:.|.:.:.::.:....|.:.|..||..|.:..:.:.|:   |..||||:|..|
Worm   112 HRNGQGLVMEYMDCGCVADLIYDRKNIEYKMDHVASWMYQLSSAVNFFHS---KDQIHRDLKLQN 173

  Fly   146 LLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRK 210
            :||::..|.||||||||.......||:||||...||||:|....|..|.||||..|::|::::|.
Worm   174 MLLSHHHRTLKICDFGTFTSIHQSMTSNRGSPITMAPEIFRCEPYNMKADIFSIGIIMWQMIARD 238

  Fly   211 QPF-------KGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMH 268
            .|:       ..:.|..|...:.::.|..|:|:...||       ||...|..||:....|....
Worm   239 HPYTMNMPITPFLYNVATRNLRPHEIECNPILSNFYKR-------CWSDNPASRPTSADCVEYFR 296

  Fly   269 EIVKDY-----------TGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQE-------GELSP 315
            .:..:|           :||...::        :.|...|  ...|..|...|       .|::|
Worm   297 CLRSEYPNGNVPLWDPASGASNTVK--------IPKSQPG--GRSPLPLPKTEITPDVKPKEVAP 351

  Fly   316 SSTQLTPTTAANANVNAIAISKTTTSSMTEN-------TSSTSSDITPTNSGQLDNNPL----FY 369
            :..|.||....    :.:.:.|.......|.       |:.::.|..|.:..:.|.:.|    .:
Worm   352 AKVQETPALLP----DTLKVPKVERQISNEEEKQKIFMTALSNEDTRPIDPNEGDESSLELYHQH 412

  Fly   370 MVTNRWDAIPEEESNESRNDSFNLTSS-AEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLS 433
            .:.|...|.......|:.|:...|... ||..:.||.:..    :||  :||.....|.|    :
Worm   413 CLVNLNYAEVLLAKKEAINEKHKLVQKWAEHERTLELLER----IAC--LEQEIAYQECN----N 467

  Fly   434 PSESSSSS 441
            ..|.||.|
Worm   468 AKEKSSFS 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	82/254 (32%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	84/276 (30%)
Y105C5A.24	NP_502888.2	PKc_like	49..287	CDD:389743	81/249 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3561
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346131at33208
OrthoFinder	1	1.000	-	-		FOG0000676
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4191
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.730