DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tak1 and mlk-1

DIOPT Version :10

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_001300151.1 Gene:mlk-1 / 178895 WormBaseID:WBGene00003374 Length:1059 Species:Caenorhabditis elegans


Alignment Length:660 Identity:153/660 - (23%)
Similarity:253/660 - (38%) Gaps:176/660 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KVGHGSYGVVCK----------------AVWRDKLVAVKEF--FASAEQKDI---EKEVKQLSR- 66
            ::|||:...|.|                ||......|:|.|  .||..:.|:   :::::||.| 
 Worm   155 QIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKRE 219

  Fly    67 ------VKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHG-KVKPAYSLAHAMSWARQCAEG 124
                  :.|.||:.|.||........|::|..||.||.|.... ....|..|...:.||.|.|||
 Worm   220 ANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEG 284

  Fly   125 LAYLHAMTPKPLIHRDVKPLNLLLTNK------------------GR------NLKICDFGTVAD 165
            :.||   |.:..:|||:|..|:|:..:                  |:      .|||.||| |..
 Worm   285 MEYL---TKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFG-VTR 345

  Fly   166 KSTMMTN---NRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKI- 226
            |.|...|   ..|:.||:|||.|:...::|..|::|:.:||||:|:|::|::|...| ||.::| 
 Worm   346 KMTADANRFSTAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPA-TIAFQIA 409

  Fly   227 YKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTG--------------- 276
            .||:...:..:||.|.:.||..||...|..||....:.....:..|::..               
 Worm   410 NKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKEL 474

  Fly   277 -----ADKALEY-------TFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANAN 329
                 |||..|.       .:.....:.:::..::|  |::.:.:.....|....:|..|...  
 Worm   475 YSECFADKTKEEFEKRFHDLYAGSGDINRKNRHSIA--PETKARRLKHHKPKKADITGPTEVK-- 535

  Fly   330 VNAIAISKTTTS--SMTENTSSTSSDITPTNSGQ----LDNNPLFYMVTNRWDAIPEEESNESRN 388
             :.:::.|...:  ..|.:.|||...:...|..|    |.:..||::             :...:
 Worm   536 -HILSVQKDDKNFRVKTYDQSSTGGTLPRLNERQSTLSLSSPDLFHI-------------SNLIS 586

  Fly   389 DSFNLTSSAEATQRLETIRN--GMILMACKPMEQLTLDVEANGF-------DLSPSESSSS---- 440
            .|..:..||....|...||:  ....|...|:...|:| ::|.|       ::.|:.|..|    
 Worm   587 GSNTVGHSAHRISRKNAIRHKKNQHRMFESPVVSPTMD-DSNTFSTIDNADEVDPNHSKESKKGG 650

  Fly   441 ------------STNAKSDGRERLTVTDTKPVMMTTDLSN-------NNGGIHAHSNGLL----- 481
                        ..::|.|..||...........:|..||       ..|   |.:.|||     
 Worm   651 TLSRAWAKLPWNKRDSKEDHDERAVAGSISSRSSSTTSSNRLITGQTTRG---ASAAGLLEIGAR 712

  Fly   482 ----SHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDE----NDGTEQSLAEI-LDPELQPEP 537
                |.|:||   ::....::|:          |.|.:..    .:.||:.:.:: .|..|:|..
 Worm   713 SRAQSTADGW---EDPNTTKKHK----------VSPSDKRPVKTTNQTERYVKDLEKDTPLRPAQ 764

  Fly   538 PIPNDAESQL 547
            ..|...:|.|
 Worm   765 LPPTHRKSAL 774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 STKc_TAK1 25..275 CDD:270960 92/306 (30%)
mlk-1NP_001300151.1 SH3 75..124 CDD:473055
Protein Kinases, catalytic domain 156..446 CDD:473864 91/294 (31%)
Blue background indicates that the domain is not in the aligned region.

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