DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tak1 and mlk-1

DIOPT Version :9

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_001300151.1 Gene:mlk-1 / 178895 WormBaseID:WBGene00003374 Length:1059 Species:Caenorhabditis elegans


Alignment Length:660 Identity:153/660 - (23%)
Similarity:253/660 - (38%) Gaps:176/660 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KVGHGSYGVVCK----------------AVWRDKLVAVKEF--FASAEQKDI---EKEVKQLSR- 66
            ::|||:...|.|                ||......|:|.|  .||..:.|:   :::::||.| 
 Worm   155 QIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKRE 219

  Fly    67 ------VKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHG-KVKPAYSLAHAMSWARQCAEG 124
                  :.|.||:.|.||........|::|..||.||.|.... ....|..|...:.||.|.|||
 Worm   220 ANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEG 284

  Fly   125 LAYLHAMTPKPLIHRDVKPLNLLLTNK------------------GR------NLKICDFGTVAD 165
            :.||   |.:..:|||:|..|:|:..:                  |:      .|||.||| |..
 Worm   285 MEYL---TKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFG-VTR 345

  Fly   166 KSTMMTN---NRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKI- 226
            |.|...|   ..|:.||:|||.|:...::|..|::|:.:||||:|:|::|::|...| ||.::| 
 Worm   346 KMTADANRFSTAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPA-TIAFQIA 409

  Fly   227 YKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTG--------------- 276
            .||:...:..:||.|.:.||..||...|..||....:.....:..|::..               
 Worm   410 NKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKEL 474

  Fly   277 -----ADKALEY-------TFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANAN 329
                 |||..|.       .:.....:.:::..::|  |::.:.:.....|....:|..|...  
 Worm   475 YSECFADKTKEEFEKRFHDLYAGSGDINRKNRHSIA--PETKARRLKHHKPKKADITGPTEVK-- 535

  Fly   330 VNAIAISKTTTS--SMTENTSSTSSDITPTNSGQ----LDNNPLFYMVTNRWDAIPEEESNESRN 388
             :.:::.|...:  ..|.:.|||...:...|..|    |.:..||::             :...:
 Worm   536 -HILSVQKDDKNFRVKTYDQSSTGGTLPRLNERQSTLSLSSPDLFHI-------------SNLIS 586

  Fly   389 DSFNLTSSAEATQRLETIRN--GMILMACKPMEQLTLDVEANGF-------DLSPSESSSS---- 440
            .|..:..||....|...||:  ....|...|:...|:| ::|.|       ::.|:.|..|    
 Worm   587 GSNTVGHSAHRISRKNAIRHKKNQHRMFESPVVSPTMD-DSNTFSTIDNADEVDPNHSKESKKGG 650

  Fly   441 ------------STNAKSDGRERLTVTDTKPVMMTTDLSN-------NNGGIHAHSNGLL----- 481
                        ..::|.|..||...........:|..||       ..|   |.:.|||     
 Worm   651 TLSRAWAKLPWNKRDSKEDHDERAVAGSISSRSSSTTSSNRLITGQTTRG---ASAAGLLEIGAR 712

  Fly   482 ----SHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDE----NDGTEQSLAEI-LDPELQPEP 537
                |.|:||   ::....::|:          |.|.:..    .:.||:.:.:: .|..|:|..
 Worm   713 SRAQSTADGW---EDPNTTKKHK----------VSPSDKRPVKTTNQTERYVKDLEKDTPLRPAQ 764

  Fly   538 PIPNDAESQL 547
            ..|...:|.|
 Worm   765 LPPTHRKSAL 774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 TyrKc 19..264 CDD:197581 91/296 (31%)
STKc_TAK1 25..275 CDD:270960 92/306 (30%)
mlk-1NP_001300151.1 SH3 75..124 CDD:302595
STYKc 153..450 CDD:214568 91/299 (30%)
PKc_like 156..446 CDD:304357 91/294 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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