DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and kin-26

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_501309.1	Gene:	kin-26 / 177575	WormBaseID:	WBGene00002208	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	298	Identity:	84/298 - (28%)
Similarity:	145/298 - (48%)	Gaps:	26/298 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWRDK------LVAVKEF----FASAEQKDIEKEVKQLSRVK 68
            ::..:||:.:|:|.|::|.|...|.:.|      .||:|:.    ...|:.||...|.:.:.::.
Worm   125 LEHDQITIHKKLGEGAFGEVSSGVMKFKKGMKTVQVAIKQVKLDKTGKAKIKDFLAEARTMRKLG 189

  Fly    69 HPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTP 133
            |.|||..:|:...|:..||:||.|..|:|.:||  |.....|:........|.|.||.|:|.
Worm   190 HQNIIKFYGVGVLQEPLYLVMELAVNGALDSFL--KKNEDLSVDKKTEMILQAAWGLEYIHG--- 249

  Fly   134 KPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKST--MMTNNRGSAAWMAPEVFEGSKYTEKCDI 196
            ||::|||:...|.|.|: |: :||.|||...:.:.  :..|.:....|:|.|..:....:||.|:
Worm   250 KPMLHRDIAARNCLYTD-GK-VKISDFGLTRNGTVYQIKPNTKSPIRWLAIETIKTMICSEKTDV 312

  Fly   197 FSWAIVLWEVLSR-KQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSM 260
            :::.::.||:.:. .:|:.|:..| .:..::..|.|.|........|:.:|..|....|.|||||
Worm   313 WAYGVLCWEIFNNAAEPYPGMKPA-DVATQVANGYRMPPYPHAQAEIQTMMARCNAENPNDRPSM 376

  Fly   261 QYIVGVMHEIVK----DYTG-ADKALEYTFVNQQIVTK 293
            ..|..::..:.:    ::|. |.|..|...:...:.||
Worm   377 AEIAEILQRVTETPRPNFTAIAKKEAEELLLMNSVTTK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	77/257 (30%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	75/266 (28%)
kin-26	NP_501309.1	SH2_Fps_family	15..108	CDD:198224
		TyrKc	130..383	CDD:197581	78/260 (30%)
		PTKc	134..384	CDD:270623	76/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3561
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950