DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and let-23

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001300607.1	Gene:	let-23 / 174462	WormBaseID:	WBGene00002299	Length:	1335	Species:	Caenorhabditis elegans

Alignment Length:	486	Identity:	106/486 - (21%)
Similarity:	193/486 - (39%)	Gaps:	131/486 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AAYVDFSEIT------------------------LREKVGHGSYGVVCKAVWRDKL-------VA 44
            |..||..|:|                        |.:|:|.|::|.|...::..|.       ||
Worm   865 AEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVA 929

  Fly    45 VKEFFASAEQKD-IEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNF--LHGKVK 106
            :|.|.....|.| :.:|...:.|::|.|::.:.|...:.....::..:...|:|.||  ||   |
Worm   930 IKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLH---K 991

  Fly   107 PAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTV------AD 165
            ........:.:..|.|.|:.||.   .:.::|||:...|:|: .|..:::|.|||..      ||
Worm   992 ENLGAREQVLYCYQIASGMQYLE---KQRVVHRDLATRNVLV-KKFNHVEITDFGLSKILKHDAD 1052

  Fly   166 KSTMMTNNRGSAA--WMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQ-PFKGI--DNAYTIQWK 225
            ..|:.:   |..|  |:|.|:|....||...|::::.:..||:::..| |::|:  |:.:..
Worm  1053 SITIKS---GKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNF--- 1111

  Fly   226 IYKGER---PPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDY------------- 274
            :..|.|   ||   .|.:.:...:..||...|:.||..:    :::|..|::
Worm  1112 LKDGNRLSQPP---NCSQDLYQELLRCWMADPKSRPGFE----ILYERFKEFCKVPQLFLENSNK 1169

  Fly   275 -TGADKALEYTFVNQQIVTKE------------SDGTVAAQPDSLSSQ------EGEL------- 313
             :.:|.:.|..|..::|  :|            ..|::.:.|.|.:|.      .|:|
Worm  1170 ISESDLSAEERFQTERI--REMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSV 1232

  Fly   314 SPSSTQLTP----TTAANANVNAIAISKTTTSSMTENTSSTSSD----------------ITPTN 358
            :.|..:..|    :||...|...|..:|....|....|:.|:.|                .||::
Worm  1233 NSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNGDYYNQPNTPSS 1297

  Fly   359 SGQLDNNPLFYMVTNRWDAIPEEESNESRND 389
            |....|.|  ::.|.:.:...|.|:.:..|:
Worm  1298 SSGYYNEP--HLKTKKPETSEEAEAVQYENE 1326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	69/292 (24%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	68/287 (24%)
let-23	NP_001300607.1	Recep_L_domain	77..205	CDD:279382
		Furin-like	229..378	CDD:279142
		FU	274..>308	CDD:238021
		Recep_L_domain	396..503	CDD:279382
		GF_recep_IV	531..652	CDD:291509
		FU	532..580	CDD:238021
		FU	578..625	CDD:214589
		FU	759..806	CDD:214589
		PKc_like	885..1164	CDD:304357	70/298 (23%)
		TyrKc	898..1153	CDD:197581	69/274 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910