Protein Alignment Tak1 and Abl1

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001106174.1
• Gene: Abl1 / 11350
• MGIID: 87859
• Length: 1142
• Species: Mus musculus
• Alignment Length: 492
• Identity: 128/492 - (26%)
• Similarity: 211/492 - (42%)
• Gaps: 99/492 - (20%)

  Fly    17 SEITLREKVGHGSYGVVCKAVWR--DKLVAVKEFFA-SAEQKDIEKEVKQLSRVKHPNIIALHGI 78
            ::||::.|:|.|.||.|.:.||:  ...||||.... :.|.::..||...:..:||||::.|.|:
Mouse   259 TDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 323

  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKP 143
            .:.:...|:|.||...|:|.::|....:...|....:..|.|.:..:.||.   .|..||||:..
Mouse   324 CTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLE---KKNFIHRDLAA 385

  Fly   144 LNLLLTNKGRN--LKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFS 198
            .|.|:   |.|  :|:.|||.    |.:||.:..:|        .|.|||....:|::.|.|:::
Mouse   386 RNCLV---GENHLVKVADFGL----SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWA 443

  Fly   199 WAIVLWEVLS-RKQPFKGID--NAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSM 260
            :.::|||:.: ...|:.|||  ..|.:..|.|:.|||   ..||:::.:||.|||:..|.||||.
Mouse   444 FGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERP---EGCPEKVYELMRACWQWNPSDRPSF 505

  Fly   261 QYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQ-EGELSPSSTQLTPTT 324
            ..|    |:          |.|..|                |..|:|.: |.||....|:    .
Mouse   506 AEI----HQ----------AFETMF----------------QESSISDEVEKELGKRGTR----G 536

  Fly   325 AANANVNAIAISKTTTSSMTENTSSTSSDITPT----------NSGQLDNNPLFYMVTNRWDAIP 379
            .|.:.:.|   .:..|.:.|...::...|...|          .|..||:.|....:..|.:..|
Mouse   537 GAGSMLQA---PELPTKTRTCRRAAEQKDAPDTPELLHTKGLGESDALDSEPAVSPLLPRKERGP 598

  Fly   380 EEES-NES-----RNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSPSESS 438
            .:.| ||.     |:...||.|:....::         .||..|.::.:...|.:|   .|....
Mouse   599 PDGSLNEDERLLPRDRKTNLFSALIKKKK---------KMAPTPPKRSSSFREMDG---QPDRRG 651

  Fly   439 SSSTNAKS--DGRERLTVTDTKPVMMTTDLSNNNGGI 473
            :|..:::.  :|...||....:|.  .:..::|..|:
Mouse   652 ASEDDSRELCNGPPALTSDAAEPT--KSPKASNGAGV 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	83/265 (31%)
Abl1	NP_001106174.1	SH3_Abl	84..137	CDD:212784
		SH2_ABL	142..235	CDD:198189
		PTKc_Abl	254..516	CDD:270645	88/283 (31%)
		FABD	1018..1142	CDD:197885