DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tak1 and RIPK3

DIOPT Version :9

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_006862.2 Gene:RIPK3 / 11035 HGNCID:10021 Length:518 Species:Homo sapiens


Alignment Length:588 Identity:133/588 - (22%)
Similarity:214/588 - (36%) Gaps:148/588 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 AAYVDFSEITLREKVGHGSYGVVCKAVWR----DKLVAVKEFFASAEQKDIEKEVKQLSRVKHPN 71
            |..|...|:..:|.||.|.:|.|.:|..|    |  ||||    ....|.|.:|||.::.:.:..
Human    13 APLVSIEELENQELVGKGGFGTVFRAQHRKWGYD--VAVK----IVNSKAISREVKAMASLDNEF 71

  Fly    72 IIALHGI---SSYQQ--ATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAM 131
            ::.|.|:   .::.|  ...|:.:|.|.|||...|..:....:.|...:  .::...|:.|||..
Human    72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL--LKEVVLGMFYLHDQ 134

  Fly   132 TPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR---------GSAAWMAPEVF-- 185
            .| .|:|||:||.|:|| :...::|:.|||.    ||....::         |:..::|||:|  
Human   135 NP-VLLHRDLKPSNVLL-DPELHVKLADFGL----STFQGGSQSGTGSGEPGGTLGYLAPELFVN 193

  Fly   186 EGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLL--------TTCPKRI 242
            ...|.:...|::|:.|::|.||:.::.....:.:...:....:..||.|.        |...:.:
Human   194 VNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGL 258

  Fly   243 EDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLS 307
            ::||..||.:.|:||||.|..:....|:.                 |:|....:..|:...|.||
Human   259 KELMQLCWSSEPKDRPSFQECLPKTDEVF-----------------QMVENNMNAAVSTVKDFLS 306

  Fly   308 SQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFY--- 369
                :|..|:.:.:...:...........:|..:..:.|....|..:...|   |:..|...   
Human   307 ----QLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLN---LEEPPSSVPKK 364

  Fly   370 --MVTNRWDA----IPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEAN 428
              .:|.|..|    :|:..:..:.:||.   :....|....|.||.|                  
Human   365 CPSLTKRSRAQEEQVPQAWTAGTSSDSM---AQPPQTPETSTFRNQM------------------ 408

  Fly   429 GFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEE 493
                    .|.:||...|.|..                 .|.|   |...|:     .|..|..|
Human   409 --------PSPTSTGTPSPGPR-----------------GNQG---AERQGM-----NWSCRTPE 440

  Fly   494 LQEQEHEQ--EIVNSLDVDVDPDEDENDGTEQSLAEI----LDPE-----LQPEPPI-----PND 542
            ........  .|.|...|.|.   |.|..|.|....:    |.|.     ||..||:     |.|
Human   441 PNPVTGRPLVNIYNCSGVQVG---DNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKD 502

  Fly   543 AES 545
            .|:
Human   503 PEA 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 TyrKc 19..264 CDD:197581 75/272 (28%)
STKc_TAK1 25..275 CDD:270960 75/277 (27%)
RIPK3NP_006862.2 S_TKc 22..280 CDD:214567 75/271 (28%)
PKc_like 27..280 CDD:304357 74/266 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..443 24/141 (17%)
RHIM 419..468 CDD:289491 14/76 (18%)
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455 450..466 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..518 9/30 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.