DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and map3k9

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_002936940.2	Gene:	map3k9 / 100488949	XenbaseID:	XB-GENE-989075	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	731	Identity:	182/731 - (24%)
Similarity:	287/731 - (39%)	Gaps:	161/731 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQ------KDIEKEVKQLSR 66
            |||...:||||:.|.|.:|.|.:|.|.:|:|..:.||||......::      :::.:|.|..:.
Frog   164 ALQLEEIDFSEMVLEEIIGIGGFGKVYRAIWGQEEVAVKAARHDPDEDISQTIENVRQEAKLFAM 228

  Fly    67 VKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAM 131
            :.|||||||.|:...:....|:||||.||||:..|.||..|...|   ::||.|.|.|:.|||..
Frog   229 LDHPNIIALRGVCLKEPNLCLVMEFARGGSLNRVLSGKKIPPDIL---VNWAVQIARGMNYLHNE 290

  Fly   132 TPKPLIHRDVKPLNLLLTNKGRN-------LKICDFGTVAD--KSTMMTNNRGSAAWMAPEVFEG 187
            ...|:||||:|..|:|:.....|       |||.|||...:  ::|.| :..|:.|||||||...
Frog   291 AIVPVIHRDLKSSNVLILQMVENGDLSKKILKITDFGLAREWHRTTKM-SAAGTYAWMAPEVIRS 354

  Fly   188 SKYTEKCDIFSWAIVLWEVLSRKQPFKGIDN---AYTIQWKIYKGERPPLLTTCPKRIEDLMTAC 249
            |.:::..|::|:.::|||:|:.:.||:|||.   ||.:......   .|:.:|||:....||..|
Frog   355 SMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLS---LPIPSTCPEPFARLMEDC 416

  Fly   250 WKTVPEDRPSMQYIVGVM----------------HEIVKDYTGADKALEYTFVNQQIVTKESDGT 298
            |...|..||....|:..:                |.:.:|:   .:.::..|  .|:..||.:
Frog   417 WNPDPHCRPPFTNILFQLTTIEESGFFEMPKESFHSLQEDW---KREIQEMF--DQLRAKEKE-- 474

  Fly   299 VAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLD 363
                   |.|.|.|||         .||....|...:.:.....:.|.    ..||.     :.:
Frog   475 -------LRSWEEELS---------RAALEQKNHEELLRRREQELAER----EIDIL-----ERE 514

  Fly   364 NNPLFYMVTNRWDAIPEEESNESRN----DSFNLTSSAEATQRLETI--------RNGMILMACK 416
            .|.:.:.:......:.:.:....:|    ...|:.|.....|...|:        |..:|.....
Frog   515 LNIIIHQLCQEKPKVKKRKGKFKKNKLKLKDGNIISLPSDFQHKFTVQASPTMDKRKSLINTKFS 579

  Fly   417 PMEQLTLDVEANGFDLSPSESS---SSSTNAKSDGRERLTVTDTKPVMMT--------TDLSNNN 470
            |....|:........|:|.:|:   :.||....|..|.....:||..:.|        .|.....
Frog   580 PPASPTIIPRLRAIQLTPGDSNITKNCSTAGLKDESEEDEKKETKKKVRTWASGALGNRDSGAGE 644

  Fly   471 GGIHAHSNGLLSHANGWQARDEELQEQE-------HEQEIVNSLDVDVDPDEDEN---------- 518
            .|:.|.:.||...::......:.|:...       .|..:.|:.|.....|..|:
Frog   645 EGLRASAEGLKPCSSNTSNHGKPLRTSSTPGFNAVTETGVENTADTANQADSKESHTPTPNKSYL 709

  Fly   519 -------DGTEQSLAEILDPELQPEPPIP-NDAES--QL-----IYRDHRHMAKEYLSVDTNLYY 568
                   |..|...::      ..|.|.| |.|.|  ||     :.|..:|.....:.:......
Frog   710 CIPFHKGDDVEGPFSD------TSENPTPVNSANSTPQLTPTNSLKRGSQHKRCSLVLLGCGALL 768

  Fly   569 AQ-----DFKDKLIVQMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQYASRQLAAGHHPQPHPH 628
            |.     |..:....|:.:.|.|.|:|..:|       :||:     |.|:|       |:....
Frog   769 ATVGLGFDLMEAGKCQLGQEEPEPKEEKKKK-------ESLF-----QRAAR-------PRRSTS 814

  Fly   629 PHPNQL---QHPHSHP 641
            |...:|   :...|||
Frog   815 PPSKKLFRKEESPSHP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	94/262 (36%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	95/283 (34%)
map3k9	XP_002936940.2	SH3_MLK1-3	84..141	CDD:212992
map3k9	XP_002936940.2	STKc_MLK1	168..437	CDD:271047	99/275 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000