Protein Alignment Tak1 and map3k10

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: XP_002938858.3
• Gene: map3k10 / 100488058
• XenbaseID: XB-GENE-920944
• Length: 990
• Species: Xenopus tropicalis
• Alignment Length: 696
• Identity: 170/696 - (24%)
• Similarity: 276/696 - (39%)
• Gaps: 150/696 - (21%)

  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWRDKLVAVK--------EFFASAEQKDIEKEVKQLSRVKHP 70
            ::|.|:.|.|.:|.|.:|.|.|.:||...||||        :...:||  ::.:|.|....:.||
 Frog   114 IEFEELNLEEIIGVGGFGKVYKGLWRGDEVAVKAVRHDPDEDINVTAE--NVRQEAKLFCMLCHP 176

  Fly    71 NIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKP 135
            |||||.|:........|:||:|.||.||..|.||..||:.|   ::||.|.|.|:.|||.....|
 Frog   177 NIIALKGVCLKPPHLCLVMEYARGGPLHRALAGKKVPAHVL---VNWAVQIARGMNYLHNEAIVP 238

  Fly   136 LIHRDVKPLNLLLTNK-------GRNLKICDFGTVAD--KSTMMTNNRGSAAWMAPEVFEGSKYT 191
            :||||:|..|:|:..|       .:.|||.|||...:  |:|.| :..|:.|||||||...|.::
 Frog   239 IIHRDLKSSNILILEKVEHDDLFNKTLKITDFGLAREWQKTTKM-SAAGTYAWMAPEVIRLSLFS 302

  Fly   192 EKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP-PLLTTCPKRIEDLMTACWKTVPE 255
            :..|::|:.::|||:|:.:.|::.|| |..:.:.:...:.. |:.:|||:....::.|||...|.
 Frog   303 KSSDVWSFGVLLWELLTGEVPYREID-ALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPH 366

  Fly   256 DRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQP--DSLSSQEGELSPSST 318
            .|||...       |::..|..:::..:....:...:.:.|..:..|.  |.|.::|.||.....
 Frog   367 SRPSFSC-------ILEQLTTIEQSAMFQMPLESFHSLQEDWRLEIQQMFDELRTKEKELRSREE 424

  Fly   319 QLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEES 383
            :|  ..||...    .|.:.......:..:....||.     :.:.|.:.|.:......:.:.:.
 Frog   425 EL--VRAAEEQ----RILEEMLKRREQELAEREIDIV-----ERELNIIMYQMYQEKPKVKKRKG 478

  Fly   384 NESRN----DSFNLTSSAEATQRLETIRNGMILMACK---------PMEQLTLDVEANGFDLSPS 435
            |..::    ...|..|.....:...|::....|..||         |...|.:. ......|:|.
 Frog   479 NFKKSRLKLKDGNRISLPSGFEHKITVQASPTLDKCKGQGSSSYSPPGSPLIIP-RLRAIRLTPV 542

  Fly   436 ESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQEQEHE 500
            :.|      |:.||..:...|      ..:.||...|            ..|.....:.:|:...
 Frog   543 DGS------KTWGRSSVLKKD------EVNTSNKKKG------------RTWGPSSTQQKERAGG 583

  Fly   501 QEIVNSLDVDVDPDEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVDTN 565
            :|.:.:|          .:|::|..:..  |.|...|             .|..::..:.|:
 Frog   584 EERLKTL----------GEGSKQWSSSA--PNLGKSP-------------KHTPISVGFASL--- 620

  Fly   566 LYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKEGL--QSLYNNLQQQYASRQLAAGHHPQPHPH 628
                             ||.|:       ..|.:|.  ||.|:  .|.|.:  |.|....:.||.
 Frog   621 -----------------TEMEE-------YADADGSVPQSPYS--AQSYLT--LPAQSDLRNHPE 657

  Fly   629 PHPNQLQHPHSHPPMHFLQDE--------GCGLLPGSVCGGSESVE 666
             ..:|...|.|..|....|..        ||..|..:|..||:..|
 Frog   658 -DTSQAAAPSSDSPKRGSQSRRKSELVLLGCASLLAAVALGSDLSE 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	94/267 (35%)
map3k10	XP_002938858.3	SH3_MLK1-3	37..94	CDD:212992
		STKc_MLK2	124..381	CDD:271050	95/270 (35%)