DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and abl2

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_002937405.1	Gene:	abl2 / 100487790	XenbaseID:	XB-GENE-6459814	Length:	1100	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	157/712 - (22%)
Similarity:	282/712 - (39%)	Gaps:	141/712 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SEITLREKVGHGSYGVVCKAVWR--DKLVAVKEFFA-SAEQKDIEKEVKQLSRVKHPNIIALHGI 78
            ::||::.|:|.|.||.|...||:  :..||||.... :.|.::..||...:..:||||::.|.|:
Frog   275 TDITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGV 339

  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKP 143
            .:.:...|::.|:...|:|.::|....:...:....:..|.|.:..:.||..   |..||||:..
Frog   340 CTLEPPFYIVTEYMHYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLER---KNFIHRDLAA 401

  Fly   144 LNLLLTNKGRN--LKICDFGTVADKSTMMTNNRGSA--------AWMAPEVFEGSKYTEKCDIFS 198
            .|.|:   |.|  :|:.|||.    |.:||.:..:|        .|.|||....:.::.|.|:::
Frog   402 RNCLV---GENHVVKVADFGL----SRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWA 459

  Fly   199 WAIVLWEVLS-RKQPFKGID--NAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSM 260
            :.::|||:.: ...|:.|||  ..|.:..|.|:.|:|   ..||.::.:||.|||:..|.||||
Frog   460 FGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQP---EGCPPKVYELMRACWQWNPSDRPS- 520

  Fly   261 QYIVGVMHEIVKDYTGADKALEYTF----VNQQIVTKESDGTVAAQPDSLSSQ-EGELSPSSTQL 320
                         ::...:|.|..|    :|:::.  |..|..|....|:|.| ...:.||.::.
Frog   521 -------------FSETHQAFETMFHDSNINEEVA--EELGRTAVTSSSVSYQCRLPMLPSKSRT 570

  Fly   321 TPTTAAN-ANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESN 384
            ....|.| .|:..       |...::|::|:|   ||   |.|..:|    |.:...|:|.::.:
Frog   571 LKKKAENKENIEG-------TGDSSDNSTSSS---TP---GLLHGSP----VASGSPALPRKQRD 618

  Fly   385 ESRN--------------------DSFNLTSSA-EATQRLETIRNGMILMACKPMEQLTLDVEAN 428
            :|.:                    .||....|| :..:|..:.|.    |..:|.::..|..|..
Frog   619 KSPSSLLGDTKETTFTRDRKGGFFSSFMKKKSAPQPPKRSSSFRE----MENQPHKRPELTGELP 679

  Fly   429 GF---DLSPSESSSSSTNAKSDGRERLTVTD------------------TKPVMMTTDLSNNNGG 472
            .|   |...|.:|..|......|.:|....:                  .:.:..|..|.....|
Frog   680 SFQQLDSLDSPASPGSHKCYGGGSQRSFPPEDVIGGIGGGWTGISGFFTPRLIKKTFGLRTGKSG 744

  Fly   473 IHAHSNGLLSHANGWQARDEELQEQEH------------EQEIVNSLDVDVDPDEDEND----GT 521
            ...........:|...:....:.||:.            :.::..:..:...|:|.::|    |.
Frog   745 SSGEEPKPFPRSNSTSSMSPAVPEQDRLSMTLPRNCHRTKVQLDRTTSISSQPEESQHDLQRSGL 809

  Fly   522 E-QSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTER 585
            | |.:.:.:.|::.|...:...........|.:....::....|:.:.......|:.|.:..:.|
Frog   810 EIQPVRDRVKPKMLPRTGVSERNGGLRTGADEKSSPNKHTGGATSAFSTAAHNHKVPVLISPSPR 874

  Fly   586 EQKQELLRKMKDKEGLQSLYNNLQQQY---ASRQLAAGHH---PQPHPHPHPN--QLQHPHS 639
            ....|:  ::...:.|...:..||:..   .|.:....|.   |:..|.|.||  .||.|.:
Frog   875 NASTEV--QLVGMDSLGHTFKLLQEHVPPTGSERDRPSHRRLKPKCAPPPPPNLRLLQPPQA 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	79/260 (30%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	76/265 (29%)
abl2	XP_002937405.1	SH3_Abl	100..153	CDD:212784
		SH2_ABL	158..251	CDD:198189
		PTKc_Abl	270..532	CDD:270645	81/283 (29%)
		F_actin_bind	984..1100	CDD:385063
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910