DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp31 and Prpf31

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_081604.3	Gene:	Prpf31 / 68988	MGIID:	1916238	Length:	499	Species:	Mus musculus

Alignment Length:	508	Identity:	305/508 - (60%)
Similarity:	388/508 - (76%)	Gaps:	22/508 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLADELLADLEEDNDNELEEEDSEMASAEDESLLAEKLAKPAPNLMDV------DVTVQSVREL 59
            |||||||||||||..:   |||.......|:|           |.:.||      |::..||:.:
Mouse     1 MSLADELLADLEEAAE---EEEGGSYGEEEEE-----------PAIEDVQEETQLDLSGDSVKSI 51

  Fly    60 CKLRDSERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDANAIAVDIDNEISIVHKFTKE 124
            .||.||:.....:.:||.|.|:|...:|::|.||:.|||.:|||||.:.|:|:||::|:|||.::
Mouse    52 AKLWDSKMFAEIMMKIEEYISKQANVSEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRD 116

  Fly   125 KYQKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQAILTQATIMIVSVTASTTQGTMLTP 189
            ||.||||||:||:...::|:..||||||.||:.||||.||.|||.||||:||||||||||..|:.
Mouse   117 KYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSD 181

  Fly   190 AEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGASTAAKLLGIAGGLSKLSKMPA 254
            .|..:::|||:||:|||..|.:|||||||||:|||||||:|:|||||||::|:||||:.||||||
Mouse   182 EELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPA 246

  Fly   255 CNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRKAARLVAAKSVLAARVDACHES 319
            ||:.:||||:|||||||.|.:||||||:|:|.|||...||||||||||||||..||||||:.|||
Mouse   247 CNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHES 311

  Fly   320 VHGEIGLRFKEDVEKKLDKLQEPPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQAN 384
            ..|::|...|:::|:|.||.|||||||.:||||.|::|.:|||||:|.||||||..|||.|||||
Mouse   312 TEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQAN 376

  Fly   385 RMNFGDIEEDAYQGDLGYSRGTIGKTGTGRIRLPQVDEKTKVRISKTLHKNLQKQQ-VYGGNTTV 448
            ||:||:|||||||.|||:|.|.:||:|:||:|..||:|.||.||||||.:.||||. ||||.:|:
Mouse   377 RMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTI 441

  Fly   449 KRQISGTASSVAFTPLQGLEIVNPQAAERSQTEANAKYFSNTSGFMSV-GQRT 500
            :.:.||||||||||||||||||||||||:...|||.||||:.:.|:.| |:::
Mouse   442 RDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	28/50 (56%)
		Nop	107..337	CDD:280047	149/229 (65%)
		Prp31_C	345..472	CDD:286825	88/127 (69%)
Prpf31	NP_081604.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		21/55 (38%)
		NOSIC	93..144	CDD:197999	28/50 (56%)
		Nop	99..329	CDD:280047	149/229 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..357		15/22 (68%)
		Prp31_C	337..465	CDD:286825	88/127 (69%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:Q8WWY3	351..364		9/12 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847397
Domainoid	1	1.000	319	1.000	Domainoid score	I1250
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5980
Inparanoid	1	1.050	599	1.000	Inparanoid score	I945
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54654
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004373
OrthoInspector	1	1.000	-	-		oto94241
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R992
SonicParanoid	1	1.000	-	-		X4161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.890