DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp31 and Nop56

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_077155.2	Gene:	Nop56 / 67134	MGIID:	1914384	Length:	580	Species:	Mus musculus

Alignment Length:	423	Identity:	99/423 - (23%)
Similarity:	186/423 - (43%)	Gaps:	53/423 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LIVDANAIAVDIDNEISIVHKFTKEKYQKRFPELDSLIVGEIEYLLAVKELGN--DLDQVKNNEK 162
            :|:.:.::...:|.:|:......:|.|...||||..::.....|....:.:||  :|::.| .||
Mouse   167 MIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIVNDNATYCRLAQFIGNRRELNEEK-LEK 230

  Fly   163 LQAI-LTQATIMIVSVTASTTQGTMLTPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPN 226
            |:.| :..|....:...:.::.|..::..:...|:......:.|:.::..::.|:.|:|:.:||:
Mouse   231 LEEITMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPS 295

  Fly   227 LSMIVGASTAAKLLGIAGGLSKLSKMPACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDT 291
            ||.::|.:..|:|:..||.|:.|:|.||..||:|||:|............|..|.:::|..:...
Mouse   296 LSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRA 360

  Fly   292 APDLRRKAARLVAAKSVLAARVDACHE---SVHGEIGLRFKEDVE-------------KKLDKLQ 340
            |...:.:.:|.:|.|..:|:|:|...|   ||.||   :.:|.||             |.||.::
Mouse   361 AAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGE---KLREQVEERLSFYETGEIPRKNLDVMK 422

  Fly   341 EPPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQANRMNFGDIEEDAYQGDLGYSRG 405
            |  .|...:.....|....:|:..||::|.|:|.|........|.....:.||
Mouse   423 E--AVVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSTPEECEE------------ 473

  Fly   406 TIGKTGTGRIRL-PQVD--EKTKVRISKTLHKNLQKQQVYG-----GNTTVKRQISGTASSVAFT 462
             :.:....:.:| ||.:  |...|.:.|:..|...|:::..     ..::.||:.|.....||..
Mouse   474 -VNEKSKKKKKLKPQENGMEDPPVSLPKSKKKKAPKEELASDLEEMATSSAKRKKSSPKEEVASE 537

  Fly   463 PLQGLEIVNPQA----AERSQTEANAKYFSNTS 491
            |.:......|:.    :|..:..||   |:.:|
Mouse   538 PEEAASPTTPKKKRKFSEEPEVAAN---FTKSS 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	10/50 (20%)
		Nop	107..337	CDD:280047	63/248 (25%)
		Prp31_C	345..472	CDD:286825	26/134 (19%)
Nop56	NP_077155.2	NOP5NT	5..70	CDD:285382
		SIK1	48..416	CDD:224415	63/252 (25%)
		NOSIC	168..219	CDD:197999	10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..580		23/126 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810