DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp31 and prpf31

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_998859.1	Gene:	prpf31 / 407890	XenbaseID:	XB-GENE-489336	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	307/501 - (61%)
Similarity:	384/501 - (76%)	Gaps:	18/501 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLADELLADL----EEDNDNELEEEDSEMASAEDESLLAEKLAKPAPNLMDVDVTVQSVRELCK 61
            |||||||||||    ||:.:|.::|:|.|......|.             |.||:..:||:.:.|
Frog     1 MSLADELLADLEEAAEEEEENLIDEDDLETIEEVQEE-------------MQVDLNAESVKSIAK 52

  Fly    62 LRDSERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDANAIAVDIDNEISIVHKFTKEKY 126
            |.||:.....|.:|:.|..:|..|:|::|.||:.|||.:|||||.:.|:|:||::|:|||.::||
Frog    53 LSDSKLFSEILLKIDGYIKKQPKASEVMGPVEAAPEYKVIVDANNLTVEIENELNIIHKFIRDKY 117

  Fly   127 QKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQAILTQATIMIVSVTASTTQGTMLTPAE 191
            .||||||:||:...::|:..||||||:||:.||||.||.|||.||||:||||||||||..||..|
Frog   118 SKRFPELESLVPNALDYIRTVKELGNNLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLTDEE 182

  Fly   192 KAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGASTAAKLLGIAGGLSKLSKMPACN 256
            ..:|:|||:||:|||..|.:|||||||||:|||||||:|||||||||::||||||:.||||||||
Frog   183 LERIEEACDMALELNQSKHRIYEYVESRMSFIAPNLSIIVGASTAAKIMGIAGGLTNLSKMPACN 247

  Fly   257 VQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRKAARLVAAKSVLAARVDACHESVH 321
            |.:||||:|||||||.|.:||||||:|:|.|||...|||.|||||||:||..||||||:.|||..
Frog   248 VMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLHRKAARLVSAKCTLAARVDSFHESSE 312

  Fly   322 GEIGLRFKEDVEKKLDKLQEPPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQANRM 386
            |::|...||::|:|.||.|||||||.:||||.|::|.:|||||:|.||||||..|||.|||||||
Frog   313 GKVGYDLKEEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRM 377

  Fly   387 NFGDIEEDAYQGDLGYSRGTIGKTGTGRIRLPQVDEKTKVRISKTLHKNLQKQQ-VYGGNTTVKR 450
            :|.:|||||||.|||:|.|.:||:|:||||..||:|.||.||||||.:.||||. ||||.:|::.
Frog   378 SFAEIEEDAYQEDLGFSLGHLGKSGSGRIRQAQVNEATKARISKTLQRTLQKQSVVYGGKSTIRD 442

  Fly   451 QISGTASSVAFTPLQGLEIVNPQAAERSQTEANAKYFSNTSGFMSV 496
            :.||||||||||||||||||||||||:...|||.||||:.:.|:.|
Frog   443 RSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	28/50 (56%)
		Nop	107..337	CDD:280047	153/229 (67%)
		Prp31_C	345..472	CDD:286825	88/127 (69%)
prpf31	NP_998859.1	Nop	98..328	CDD:366818	153/229 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..356		15/22 (68%)
		Prp31_C	336..464	CDD:370690	88/127 (69%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:Q8WWY3	350..363		9/12 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	320	1.000	Domainoid score	I1238
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5980
Inparanoid	1	1.050	601	1.000	Inparanoid score	I940
OMA	1	1.010	-	-		QHG54654
OrthoDB	1	1.010	-	-		D301572at33208
OrthoFinder	1	1.000	-	-		FOG0004373
OrthoInspector	1	1.000	-	-		oto104448
Panther	1	1.100	-	-	LDO	PTHR13904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R992
SonicParanoid	1	1.000	-	-		X4161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110