DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp31 and nop56

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_957511.2	Gene:	nop56 / 394196	ZFINID:	ZDB-GENE-040109-1	Length:	548	Species:	Danio rerio

Alignment Length:	370	Identity:	83/370 - (22%)
Similarity:	166/370 - (44%)	Gaps:	50/370 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LIVDANAIAVDIDNEISIVHKFTKEKYQKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQ 164
            :|:.:.|:...:|.:|:......:|.|...||||..::.....|....|.:||..:  .:.|.|:
Zfish   168 MIIQSIALLDQLDKDINTFSMRVREWYGYHFPELIKIVSDNSTYCKLAKLIGNRKE--LSEEMLE 230

  Fly   165 AI----LTQATIMIVSVTASTTQGTMLTPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAP 225
            |:    :..|....:...:.::.|..::|.:...|:......:.|.:::.::.||:.|:|..:||
Zfish   231 AMEEITMDSAKAQAILDASRSSMGMDISPIDLINIECFSSRVVSLTDYRQELQEYLRSKMGQVAP 295

  Fly   226 NLSMIVGASTAAKLLGIAGGLSKLSKMPACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQD 290
            ||:.::|....|:|:..||.|:.|:|.||..||:|||:|............|..|.:::|..:..
Zfish   296 NLAALIGEVVGARLISHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGR 360

  Fly   291 TAPDLRRKAARLVAAKSVLAARVDACHESVHGEIGLRFKEDVE-------------KKLDKLQE- 341
            .|...:.:.:|.:|.|..:|:|:|...|......|.:.::.||             |.||.::|
Zfish   361 AAAKNKGRISRYLANKCTIASRIDCFSEVPTSVFGDKLRDQVEERLAFYETGEAPRKNLDVMKEA 425

  Fly   342 -PPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQANRMNFGDIEEDAYQGDLGYSRG 405
             ....:....:.:.:|..:||:  |:.:|..|..:..|..::.|    ||:||:
Zfish   426 VAQASEVAAEIKRKLEKKEKKK--KKRQKKLEALSTAEGDEETN----GDVEEN----------- 473

  Fly   406 TIGKTGTGRIRLPQVDEKTKVR---------ISKTLHKNLQKQQV 441
               :..|.:.:..|..|:.:|:         :.:|..|..:|:::
Zfish   474 ---EVATKKKKKKQAAEEMEVKEDEEVTTNGVEETPGKKKKKRKI 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	12/50 (24%)
		Nop	107..337	CDD:280047	59/246 (24%)
		Prp31_C	345..472	CDD:286825	19/106 (18%)
nop56	NP_957511.2	NOP5NT	5..70	CDD:285382
		SIK1	47..414	CDD:224415	60/247 (24%)
		NOSIC	169..220	CDD:197999	12/50 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810