DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp31 and prpf31

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_956798.1	Gene:	prpf31 / 393476	ZFINID:	ZDB-GENE-040426-1561	Length:	508	Species:	Danio rerio

Alignment Length:	505	Identity:	299/505 - (59%)
Similarity:	381/505 - (75%)	Gaps:	14/505 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLADELLADLEEDND-------NELEEEDSEMASAEDESLLAEKLAKPAPNLMDVDV-TVQSVR 57
            |||||||||||||..:       .|..|.|.|....:.:..|.:     .|..|:||. :.:||.
Zfish     1 MSLADELLADLEEAGEEDGLYPGGEEGESDGEPGERQVDGGLED-----IPEEMEVDYSSTESVT 60

  Fly    58 ELCKLRDSERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDANAIAVDIDNEISIVHKFT 122
            .:.|||.|:.....:.:|.||...||..:|:.|.||:||||.|||.||.:.|:||||::|:|||.
Zfish    61 SIAKLRHSKPFAEIMDKISHYVGNQRKNSEVSGPVEADPEYRLIVAANNLTVEIDNELNIIHKFV 125

  Fly   123 KEKYQKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQAILTQATIMIVSVTASTTQGTML 187
            ::||.||||||:||:...::|:..||||||:|::.||||.||.|||.||||:|||||||||||||
Zfish   126 RDKYSKRFPELESLVPNALDYIRTVKELGNNLEKCKNNETLQQILTNATIMVVSVTASTTQGTML 190

  Fly   188 TPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGASTAAKLLGIAGGLSKLSKM 252
            ...|..:::|||:||:|||..|.:|||||||||:|||||||:|||||||||::|:||||:.||||
Zfish   191 GDDELQRLEEACDMALELNQSKHRIYEYVESRMSFIAPNLSIIVGASTAAKIMGVAGGLTNLSKM 255

  Fly   253 PACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRKAARLVAAKSVLAARVDACH 317
            ||||:.:||||::||||||.|.:||||||:|:..:||...|||||||||||:||..||:|||:.|
Zfish   256 PACNLMLLGAQRRTLSGFSSTSLLPHTGYIYHCDVVQTLPPDLRRKAARLVSAKCTLASRVDSFH 320

  Fly   318 ESVHGEIGLRFKEDVEKKLDKLQEPPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQ 382
            ||..|::|...||::|:|.||.|||||||.:||||.|::|.:|||||:|.||||||..|||.||.
Zfish   321 ESADGKVGYDLKEEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKH 385

  Fly   383 ANRMNFGDIEEDAYQGDLGYSRGTIGKTGTGRIRLPQVDEKTKVRISKTLHKNLQKQQV-YGGNT 446
            ||||.|.:||:||||.|||:|.|.:||:|:||:|..||::.||.||||:|.:.||||.: |||.:
Zfish   386 ANRMTFAEIEDDAYQEDLGFSLGQLGKSGSGRVRQAQVNDSTKARISKSLQRTLQKQSMTYGGKS 450

  Fly   447 TVKRQISGTASSVAFTPLQGLEIVNPQAAERSQTEANAKYFSNTSGFMSV 496
            ||:.:.|||:||||||||||||||||||||:...|||.|||||.:.|:.|
Zfish   451 TVRDRSSGTSSSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSNMAEFLKV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	28/50 (56%)
		Nop	107..337	CDD:280047	148/229 (65%)
		Prp31_C	345..472	CDD:286825	82/127 (65%)
prpf31	NP_956798.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		18/48 (38%)
		NOSIC	104..155	CDD:197999	28/50 (56%)
		Nop	110..340	CDD:280047	148/229 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..368		15/22 (68%)
		Prp31_C	348..476	CDD:286825	82/127 (65%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250\|UniProtKB:Q8WWY3	362..375		9/12 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..461		9/18 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592664
Domainoid	1	1.000	316	1.000	Domainoid score	I1251
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5980
Inparanoid	1	1.050	586	1.000	Inparanoid score	I962
OMA	1	1.010	-	-		QHG54654
OrthoDB	1	1.010	-	-		D301572at33208
OrthoFinder	1	1.000	-	-		FOG0004373
OrthoInspector	1	1.000	-	-		oto40008
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R992
SonicParanoid	1	1.000	-	-		X4161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900