DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp31 and Nop56

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001020903.1	Gene:	Nop56 / 362214	RGDID:	1308892	Length:	588	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	94/429 - (21%)
Similarity:	179/429 - (41%)	Gaps:	73/429 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LIVDANAIAVDIDNEISIVHKFTKEKYQKRFPELDSLIVGEIEYLLAVKELGN--DLDQVKNNEK 162
            :|:.:.::...:|.:|:......:|.|...||||..:|.....|....:.:||  :|::.| .||
  Rat   167 MIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEEK-LEK 230

  Fly   163 LQAI-LTQATIMIVSVTASTTQGTMLTPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPN 226
            |:.| :..|....:...:.::.|..::..:...|:......:.|:.::..::.|:.|:|:.:||:
  Rat   231 LEEITMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHNYLRSKMSQVAPS 295

  Fly   227 LSMIVGASTAAKLLGIAGGLSKLSKMPACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDT 291
            ||.::|.:..|:|:..||.|:.|:|.||..||:|||:|............|..|.:::|..:...
  Rat   296 LSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRA 360

  Fly   292 APDLRRKAARLVAAKSVLAARVDACHE---SVHGEIGLRFKEDVE-------------KKLDKLQ 340
            |...:.:.:|.:|.|..:|:|:|...|   ||.||   :.:|.||             |.||.::
  Rat   361 AAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGE---KLREQVEERLSFYETGEIPRKNLDVMK 422

  Fly   341 EPPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQANRMNFGDIEEDAYQGDLGYSRG 405
            |  .|...:.....|....:|:..||::|.|:|.|........|.....:.||
  Rat   423 E--AVVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSTPEECEE------------ 473

  Fly   406 TIGKTGTGRIRLPQVDEKTKVRISKTLHKN-----------LQKQQVY--------------GGN 445
                       :.:..:|.|::..:||.:|           .:|::.:              ...
  Rat   474 -----------VNEKPKKKKLKPQETLQENGMEDPPVSLPKTKKKKAFPKEELASDLEEMATSSI 527

  Fly   446 TTVKRQISGTASSVAFTPLQGLEIVNPQAAERSQTEANA 484
            :..|::.|.....||..|.:....:.|:...:...|..|
  Rat   528 SVPKKKKSLPKEEVASEPEEAASPITPKKKRKFSEEPEA 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	11/50 (22%)
		Nop	107..337	CDD:280047	64/248 (26%)
		Prp31_C	345..472	CDD:286825	23/151 (15%)
Nop56	NP_001020903.1	NOP5NT	5..70	CDD:285382
		SIK1	48..416	CDD:224415	64/252 (25%)
		NOSIC	168..219	CDD:197999	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810