DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp31 and Prpf31

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001099689.1	Gene:	Prpf31 / 292536	RGDID:	1305832	Length:	499	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	306/508 - (60%)
Similarity:	389/508 - (76%)	Gaps:	22/508 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLADELLADLEEDNDNELEEEDSEMASAEDESLLAEKLAKPAPNLMDV------DVTVQSVREL 59
            |||||||||||||..:   |||.......|:|           |.:.||      |::..||:.:
  Rat     1 MSLADELLADLEEAAE---EEEGGSYGEEEEE-----------PAIEDVQEETQLDLSGDSVKSI 51

  Fly    60 CKLRDSERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDANAIAVDIDNEISIVHKFTKE 124
            .||.||:.....:.:||.|.|:|..|:|::|.||:.|||.:|||||.:.|:|:||::|:|||.::
  Rat    52 AKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRD 116

  Fly   125 KYQKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQAILTQATIMIVSVTASTTQGTMLTP 189
            ||.||||||:||:...::|:..||||||.||:.||||.||.|||.||||:||||||||||..|:.
  Rat   117 KYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSD 181

  Fly   190 AEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGASTAAKLLGIAGGLSKLSKMPA 254
            .|..:::|||:||:|||..|.:|||||||||:|||||||:|:|||||||::|:||||:.||||||
  Rat   182 EELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPA 246

  Fly   255 CNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRKAARLVAAKSVLAARVDACHES 319
            ||:.:||||:|||||||.|.:||||||:|:|.|||...||||||||||||||..||||||:.|||
  Rat   247 CNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHES 311

  Fly   320 VHGEIGLRFKEDVEKKLDKLQEPPPVKFIKPLPKPIEGSKKKRGGKRVRKMKERYALTEFRKQAN 384
            ..|::|...|:::|:|.||.|||||||.:||||.|::|.:|||||:|.||||||..|||.|||||
  Rat   312 TEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQAN 376

  Fly   385 RMNFGDIEEDAYQGDLGYSRGTIGKTGTGRIRLPQVDEKTKVRISKTLHKNLQKQQ-VYGGNTTV 448
            ||:||:|||||||.|||:|.|.:||:|:||:|..||:|.||.||||||.:.||||. ||||.:|:
  Rat   377 RMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTI 441

  Fly   449 KRQISGTASSVAFTPLQGLEIVNPQAAERSQTEANAKYFSNTSGFMSV-GQRT 500
            :.:.||||||||||||||||||||||||:...|||.||||:.:.|:.| |:::
  Rat   442 RDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	28/50 (56%)
		Nop	107..337	CDD:280047	149/229 (65%)
		Prp31_C	345..472	CDD:286825	88/127 (69%)
Prpf31	NP_001099689.1	Nop	100..330	CDD:396390	149/229 (65%)
Prpf31	NP_001099689.1	Prp31_C	337..465	CDD:401657	88/127 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350950
Domainoid	1	1.000	319	1.000	Domainoid score	I1217
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5980
Inparanoid	1	1.050	600	1.000	Inparanoid score	I914
OMA	1	1.010	-	-		QHG54654
OrthoDB	1	1.010	-	-		D301572at33208
OrthoFinder	1	1.000	-	-		FOG0004373
OrthoInspector	1	1.000	-	-		oto97762
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13904
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4161
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.010