DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp31 and prp31

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_595294.1	Gene:	prp31 / 2540045	PomBaseID:	SPBC119.13c	Length:	518	Species:	Schizosaccharomyces pombe

Alignment Length:	514	Identity:	203/514 - (39%)
Similarity:	303/514 - (58%)	Gaps:	43/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLADELLADLEEDNDN------------------ELEEEDSEMASAEDESLL--------AEKL 39
            |||||||||||::..:.                  ||:.|:....|||.|:.|        |:||
pombe     1 MSLADELLADLDDIEETTESTITDELGPDAKKRRLELQLEEGNGISAELENDLDITKISDSAQKL 65

  Fly    40 AKPAPNLMDVDVTVQSVRELCKLRDSERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDA 104
            .....|..:     .:...:.:|.:|.||::.::..|.|...::.|  :.|::|.|.||.||||:
pombe    66 PSEVANKFN-----DNNENIYQLLNSTRLRDIIEGTEKYKGTEKQA--ITGNIEDDLEYHLIVDS 123

  Fly   105 NAIAVDIDNEISIVHKFTKEKYQKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQAILTQ 169
            |:||::||:||..:|:..||.|..|||||.||::...:|...|..|.||||   |::...:.|..
pombe   124 NSIAMEIDDEILRLHRLVKEWYHDRFPELSSLVLNAFDYCKTVSSLLNDLD---NSKTKLSFLPS 185

  Fly   170 ATIMIVSVTASTTQGTMLTPAEKAK-IDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGA 233
            ||:|:::.||:||.|..| |.|..| :...||...:|...|.||.|||:||::.:|||||.:||:
pombe   186 ATVMVIATTATTTVGKPL-PDEMIKNVKNCCEAIQQLGEEKQKIIEYVQSRISVVAPNLSAVVGS 249

  Fly   234 STAAKLLGIAGGLSKLSKMPACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRK 298
            :|||.|:||||||::|.|.||||:..||.::.|..|.:...:....|::|.|:|||.|.||:|::
pombe   250 TTAANLIGIAGGLTRLGKFPACNLPALGKRRLTTIGINNPAVSGDYGFLYMSEIVQKTPPDVRKQ 314

  Fly   299 AARLVAAKSVLAARVDACHESVHGEIGLRFKEDVEKKLDKLQEPPPVKFIKPLPKPIEGSKKKRG 363
            |.|:.|||..||||:|:.||...|..|:..:::||:|::||.|||..|....||.|.:..|::||
pombe   315 AIRMTAAKVALAARIDSIHEYPDGSFGISARKEVERKIEKLLEPPSQKPTVALPVPDDRPKRRRG 379

  Fly   364 GKRVRKMKERYALTEFRKQANRMNFGDIEEDAYQGDLGYSRGTIGKTGTGRIRLPQVDEKTKVRI 428
            |:|:|||||:||:||.|:..||:.||..|.:.:..|.....|.:|:.|.|:||...:|.:||:|:
pombe   380 GRRIRKMKEQYAVTELRRLQNRVAFGKEEAEVFNFDETEGLGMLGQEGEGKIRAVSIDSRTKLRL 444

  Fly   429 SKTLHKNLQKQQVYGGNTTVKRQISGTASSVAFTPLQGLEIVNPQAAERSQTEANAKYF 487
            .|.  :..|.|.:...|...   .||..||::|||:||:|:|||....:.:.|...|:|
pombe   445 PKA--RKAQLQSMAQKNPLA---ASGLQSSLSFTPIQGIELVNPLLQRQQKVEEANKWF 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	24/50 (48%)
		Nop	107..337	CDD:280047	103/230 (45%)
		Prp31_C	345..472	CDD:286825	50/126 (40%)
prp31	NP_595294.1	SIK1	1..400	CDD:224415	167/409 (41%)
		NOSIC	120..171	CDD:197999	24/50 (48%)
		Prp31_C	361..483	CDD:286825	50/126 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I694
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5980
Inparanoid	1	1.050	342	1.000	Inparanoid score	I497
OMA	1	1.010	-	-		QHG54654
OrthoFinder	1	1.000	-	-		FOG0004373
OrthoInspector	1	1.000	-	-		oto101610
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R992
SonicParanoid	1	1.000	-	-		X4161
TreeFam	1	0.960	-	-
	13	12.960