DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp31 and nol-56

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_505660.1	Gene:	nol-56 / 179442	WormBaseID:	WBGene00010627	Length:	486	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	101/416 - (24%)
Similarity:	184/416 - (44%)	Gaps:	50/416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DLEEDNDNELEEEDSEMASAEDESLLAEKLAKPAPNLMDV--DVTVQSVR-------ELCKLRDS 65
            ||.......|.::...:....::|.||..|.:..|:|..|  .|..:.:|       .|.|....
Worm    77 DLTNFLQKSLPKKKKHVVLGINDSKLAGSLTEAFPDLKLVFGGVITEILRGTRVHFERLAKNLPH 141

  Fly    66 ERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDANAIAVDIDNEISIVHKFTKEKYQKRF 130
            ..|......:.|..||.:...: :..|::     :::.:.|:...:|.:|::.....:|.|...:
Worm   142 HSLSKAQLSLGHSYSRSKVKFD-VHRVDN-----MVIQSIALLDQLDKDINLFGMRIREWYSYHY 200

  Fly   131 PELDSLIVGEIEY-LLAVKELGNDLDQVKNNEKLQ----AIL---TQATIMIVSVTASTTQGTML 187
            |||..|...:.:| .|||..|  |.:::..||.|:    .||   ::.|..|:. .|.|:.|..:
Worm   201 PELFRLAPDQYKYSRLAVAIL--DRNKMAENENLENEILEILDNDSEKTAQIIE-AARTSMGMDI 262

  Fly   188 TPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGASTAAKLLGIAGGLSKLSKM 252
            :..:...|.........|..::.:::||::.||...||:||.::|....|:|:..||.|:.|:|.
Worm   263 SDLDLENIKRFAARVSSLMEYRQQLHEYIKDRMDHCAPSLSALIGEQVGARLISHAGSLTNLAKY 327

  Fly   253 PACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRKAARLVAAKSVLAARVDACH 317
            ||..||:|||:|............|..|.:::|..:.......:.:.:|.:|.|..:|||||...
Worm   328 PASTVQILGAEKALFRALKTRSNTPKYGLLFHSSFIGKAGTKNKGRVSRYLANKCSIAARVDCFS 392

  Fly   318 E---SVHGEIGLRFKEDVEKKLDKLQE-PPPVKFIKPLPKPIEGS---------KKKRGGKRVRK 369
            |   |.:||.   .::.||.:|:.... ..|.|.|..:.:..|.:         |||:..|:.::
Worm   393 ETPVSTYGEF---LRQQVEDRLEYFTSGTVPKKNIDVMKEAEEAAVEVKEKVIKKKKKAAKKAKR 454

  Fly   370 MKERYALTEFRKQANRMNFGDIEEDA 395
            :.|. ::|...:       .:::|||
Worm   455 LAEE-SVTATAE-------AEVDEDA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	14/51 (27%)
		Nop	107..337	CDD:280047	67/240 (28%)
		Prp31_C	345..472	CDD:286825	12/60 (20%)
nol-56	NP_505660.1	NOP5NT	7..72	CDD:285382
		NOSIC	171..220	CDD:197999	13/48 (27%)
		Nop	177..412	CDD:280047	67/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810