DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp31 and NOP56

DIOPT Version :9

Sequence 1:	NP_648756.1	Gene:	Prp31 / 39655	FlyBaseID:	FBgn0036487	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_006383.2	Gene:	NOP56 / 10528	HGNCID:	15911	Length:	594	Species:	Homo sapiens

Alignment Length:	418	Identity:	99/418 - (23%)
Similarity:	186/418 - (44%)	Gaps:	53/418 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LIVDANAIAVDIDNEISIVHKFTKEKYQKRFPELDSLIVGEIEYLLAVKELGN--DLDQVKNNEK 162
            :|:.:.::...:|.:|:......:|.|...||||..:|.....|....:.:||  :|::.| .||
Human   167 MIIQSISLLDQLDKDINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDK-LEK 230

  Fly   163 LQAI-LTQATIMIVSVTASTTQGTMLTPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPN 226
            |:.: :..|....:...:.::.|..::..:...|:......:.|:.::..::.|:.|:|:.:||:
Human   231 LEELTMDGAKAKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPS 295

  Fly   227 LSMIVGASTAAKLLGIAGGLSKLSKMPACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDT 291
            ||.::|.:..|:|:..||.|:.|:|.||..||:|||:|............|..|.:::|..:...
Human   296 LSALIGEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRA 360

  Fly   292 APDLRRKAARLVAAKSVLAARVDACHE---SVHGEIGLRFKEDVE-------------KKLDKLQ 340
            |...:.:.:|.:|.|..:|:|:|...|   ||.||   :.:|.||             |.||.::
Human   361 AAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGE---KLREQVEERLSFYETGEIPRKNLDVMK 422

  Fly   341 EPPPVKFIKPLPKPIEGSKK--KRGGKRVRKMKERYALTEFRKQANRMNFGDIEEDAYQGDLGYS 403
            |    ..::......|.::|  |:..||::|.|:|.|....   |:..|.....|:..:    .|
Human   423 E----AMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALAL---ASSENSSSTPEECEE----MS 476

  Fly   404 RGTIGKTGTGRIRLPQVD--EKTKVRISKTLHKNLQKQQVYGGNTTVKRQISGTASSVAF----- 461
            .....|.......:||.:  |...:..||.     :|::.:.....:...:..||.|.:.
Human   477 EKPKKKKKQKPQEVPQENGMEDPSISFSKP-----KKKKSFSKEELMSSDLEETAGSTSIPKRKK 536

  Fly   462 -TPLQGLEIVN--PQAAERSQTEANAKY 486
             ||.:  |.||  .:|..||.::...|:
Human   537 STPKE--ETVNDPEEAGHRSGSKKKRKF 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp31	NP_648756.1	NOSIC	101..152	CDD:197999	11/50 (22%)
		Nop	107..337	CDD:280047	63/248 (25%)
		Prp31_C	345..472	CDD:286825	28/138 (20%)
NOP56	NP_006383.2	NOP5NT	5..70	CDD:285382
		NOSIC	168..219	CDD:197999	11/50 (22%)
		Nop	174..405	CDD:280047	62/234 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..594		23/119 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1498
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810