DRSC/TRiP Functional Genomics Resources

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Protein Alignment Msh6 and MSH2

DIOPT Version :9

Sequence 1:NP_648755.1 Gene:Msh6 / 39654 FlyBaseID:FBgn0036486 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_014551.1 Gene:MSH2 / 854063 SGDID:S000005450 Length:964 Species:Saccharomyces cerevisiae


Alignment Length:952 Identity:240/952 - (25%)
Similarity:386/952 - (40%) Gaps:211/952 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 ISFDKMSTI----LVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRG--TQV 377
            :|...::|:    |:|.|:||         ::..:..|.||:.....:  .::.::.|..  :.:
Yeast    86 VSLQVLATLLKLCLLDLGYKV---------EIYDKGWKLIKSASPGNI--EQVNELMNMNIDSSI 139

  Fly   378 FGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTS---IGDFHLGEFEDDKNC-SRLLTLVS 438
            ..:..|:..|.|           :|.|. .||.||||:   :|...:.:.|...|. |.|:.|..
Yeast   140 IIASLKVQWNSQ-----------DGNCI-IGVAFIDTTAYKVGMLDIVDNEVYSNLESFLIQLGV 192

  Fly   439 HHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNW 503
            ....|..|...|..:...|:::..:              ..|....||...:|      .|:.:.
Yeast   193 KECLVQDLTSNSNSNAEMQKVINVI--------------DRCGCVVTLLKNSE------FSEKDV 237

  Fly   504 PLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKP 568
            .|.|..:..|...|.| |....||::.|....|.::               ||....||:  .|.
Yeast   238 ELDLTKLLGDDLALSL-PQKYSKLSMGACNALIGYL---------------QLLSEQDQV--GKY 284

  Fly   569 AVASTLRRSHMVLDATTLSNLRII------------------------GEEHSLLSTLDHCCTKF 609
            .:.....:..|.|||:.:..|.:.                        |:..||...|:||.|..
Yeast   285 ELVEHKLKEFMKLDASAIKALNLFPQGPQNPFGSNNLAVSGFTSAGNSGKVTSLFQLLNHCKTNA 349

  Fly   610 GKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLA----PM-PDFERNLAQIHLFG 669
            |.|||:.||..|..::..|.:|.|.:..||    :..|:|.:|.    || ||..|...:::..|
Yeast   350 GVRLLNEWLKQPLTNIDEINKRHDLVDYLI----DQIELRQMLTSEYLPMIPDIRRLTKKLNKRG 410

  Fly   670 NKQIKQMDHPDSRAILFEE--KLYNKQK-----LQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRI 727
            |               .|:  |:|...|     :|.|.:.|:  :|....|.      ..|::.:
Yeast   411 N---------------LEDVLKIYQFSKRIPEIVQVFTSFLE--DDSPTEPV------NELVRSV 452

  Fly   728 TQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAE-------------------YD 773
            ...|.|....| |||..:...|..|.||..:......:...:.|                   .|
Yeast   453 WLAPLSHHVEP-LSKFEEMVETTVDLDAYEENNEFMIKVEFNEELGKIRSKLDTLRDEIHSIHLD 516

  Fly   774 AAMDSIGEVEKRLKTYLVEQERHFGC-RITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKK 837
            :|.|...:.:|:||  |.....|..| |:|...:.:.|......|....||...::    ||..|
Yeast   517 SAEDLGFDPDKKLK--LENHHLHGWCMRLTRNDAKELRKHKKYIELSTVKAGIFFS----TKQLK 575

  Fly   838 PSRRYTTAETRALLK--DMQHAEDTRNMVLKDLA-RRLFEKFSNHYDQWKQCIDCVANLDVLGSL 899
            .    ...||..|.|  |.|.:...|.::...|. ..:|||.|.          .:|:|||:.|.
Yeast   576 S----IANETNILQKEYDKQQSALVREIINITLTYTPVFEKLSL----------VLAHLDVIASF 626

  Fly   900 AEYAGQQMVICV-PELVSDADQPFIQLEEGYHPCANAS---TYIPNGLELGTASEAPLSLLTGPN 960
            |..:....:..: |:|.....:....|....||.....   ::|.|.:.| .:.:....::||||
Yeast   627 AHTSSYAPIPYIRPKLHPMDSERRTHLISSRHPVLEMQDDISFISNDVTL-ESGKGDFLIITGPN 690

  Fly   961 MGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLIL 1025
            ||||||.:|:||::.:|||||..:|.....:::||.|..|:||.|..|.|.|||:||:.||:.||
Yeast   691 MGGKSTYIRQVGVISLMAQIGCFVPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILETASIL 755

  Fly  1026 KHATCHSLVLLDELGRGTATYDGTAIAASVVNFLAN-LKCRTLFSTHYHNLIDFFHNDKRITLGH 1089
            |:|:.:||:::|||||||:||||..:|.::...:|: :.|..||:||:|.|.:.......:...|
Yeast   756 KNASKNSLIIVDELGRGTSTYDGFGLAWAIAEHIASKIGCFALFATHFHELTELSEKLPNVKNMH 820

  Fly  1090 MACMVE---NEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIA 1151
            :...:|   .|...|  .|.:|.|||...|...:|:|.:.|::...|:.|:|.|...:.:::.: 
Yeast   821 VVAHIEKNLKEQKHD--DEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKANELDDL- 882

  Fly  1152 LQRKITAKIVAATAGNEDTKKEKIN---------ALKDLLKQ 1184
                        ...|||.||.|::         .||.|||:
Yeast   883 ------------KTNNEDLKKAKLSLQEVNEGNIRLKALLKE 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msh6NP_648755.1 MttA_Hcf106 <44..156 CDD:294511
MutS 261..1186 CDD:223327 240/952 (25%)
MutS_I 263..375 CDD:279898 11/61 (18%)
MutS_II 391..508 CDD:282973 24/120 (20%)
MutS_III 584..>667 CDD:282977 28/111 (25%)
MutS_IV 767..859 CDD:282975 25/113 (22%)
ABC_MSH6_euk 924..1140 CDD:213253 83/222 (37%)
MSH2NP_014551.1 MutS 11..929 CDD:223327 240/952 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0249
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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