DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH5

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_010127.1	Gene:	MSH5 / 851401	SGDID:	S000002313	Length:	901	Species:	Saccharomyces cerevisiae

Alignment Length:	698	Identity:	153/698 - (21%)
Similarity:	270/698 - (38%)	Gaps:	150/698 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 RSHMVLDATTLSNLRIIGEEH-------------SLLSTLDHCCTKFGKRLLHHWLCAPSCDVSV 627
            |..||||..|:|.|.|....|             |:....:...:.:.:|:|..||..|..:..
Yeast   244 RDRMVLDENTISALHIFPTAHKLGHDKMMRNGFFSVFELFNQVSSDYARRILKSWLINPLTNKK- 307

  Fly   628 IKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYN 692
                        |:.|....:|.||      ::..|.|....::.||:.  ||  |..|..:|.:
Yeast   308 ------------RIETRYSIIRTLL------DKQNAIIFSDLSQSIKRC--PD--AFGFINQLRS 350

  Fly   693 KQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFA--------- 748
            .:...|..:.:..|  |.|...:|.     |:..:....:......|:..::...|
Yeast   351 GKSTLGTWSKVASF--LEKGIAIFQ-----LVSSLKLGSDEANILHDIKNKVDISALKECLRKVE 408

  Fly   749 TAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVE-------KRLKTYLVEQERHFGCRITYFGS 806
            |..|.|.:..|..:....|:|...|...:....:|       :..:.:|:.......|:.|
Yeast   409 TVIDFDTSRDTKTLTINTGVDNRLDECRNIYNHLEGILLDVARETQIFLLNTMPQEDCKTT---- 469

  Fly   807 DKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRAL------LKDMQHAE---DTRN 862
                      :|.....|..|.         |...|....:..:      :.::|..|   .:.|
Yeast   470 ----------KSLEKLVNAVYI---------PQLGYLVTISVLMEPLLDGIPNLQWEEIFRSSEN 515

  Fly   863 MVLKDLARRLFEKFSNHYDQWKQCID-------------------------CVANLDVLGSLAEY 902
            :..|:  .|:.|....:.|.:....|                         .::.|::|.|.|:.
Yeast   516 IYFKN--GRVLELDETYGDIYGAISDFEIEILFSLQEQILRRKTQLTAYNILLSELEILLSFAQV 578

  Fly   903 AGQQMVICVPELVSDADQPFIQLEEGYHPCANA--STYIPNG--LELGTASE--------APLSL 955
            :.::. ...|:||.  |:..:::..|.|.....  ..||||.  ::.|..||        ..:.:
Yeast   579 SAERN-YAEPQLVE--DECILEIINGRHALYETFLDNYIPNSTMIDGGLFSELSWCEQNKGRIIV 640

  Fly   956 LTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNE 1020
            :||.|..|||..:.:.||:|.:||||..:||...|:.:.|:|.||:..|:.:....|:||::..:
Yeast   641 VTGANASGKSVYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQ 705

  Fly  1021 TSLILKHATCHSLVLLDELGRGTATYDGTAIAASV-VNFLANLKC-RTLFSTHYHNLID---FFH 1080
            .:..|..||..||:|:||.|:||...||.::..|: :|...:.|| |.:..||:|.|.:   ...
Yeast   706 MAKSLSLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNENVLTE 770

  Fly  1081 NDKRITLGHMACMVENEDN--------ADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGII 1137
            |.|.|.......::..:.|        .|...|.:|||:|...|...:|:|...||:.|:.:.|:
Yeast   771 NIKGIKHYCTDILISQKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCAKVCGLSRDIV 835

  Fly  1138 KRAYELSKKV----EAIALQRKITAKIVAATAGNEDTKKEKINALKDL 1181
            :||.|||:.:    :.:.....:|.|.:.....|::..|:.::...||
Yeast   836 ERAEELSRMINRGDDVVQQCGNLTEKEMREFQKNQEIVKKFLSWDLDL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	153/698 (22%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973
		MutS_III	584..>667	CDD:282977	18/95 (19%)
		MutS_IV	767..859	CDD:282975	14/107 (13%)
		ABC_MSH6_euk	924..1140	CDD:213253	72/240 (30%)
MSH5	NP_010127.1	MutS	1..898	CDD:223327	153/698 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810