DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH4

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_116652.1	Gene:	MSH4 / 850545	SGDID:	S000001891	Length:	878	Species:	Saccharomyces cerevisiae

Alignment Length:	859	Identity:	182/859 - (21%)
Similarity:	331/859 - (38%)	Gaps:	175/859 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 MLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQ 457
            :..|.|......:|.|:|.|:.:.|..:|.:|.|.:...|::..:..:.|...|...|:|:....
Yeast   106 LCCIYEVPRDISTRIGLCIINCNTGQMYLSDFMDSQIYIRVVHKLQIYQPTEILIPSSSLAPTVS 170

  Fly   458 QIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPN 522
            ::...:...:.:......|...|.                .|.|....:.:.:..|      |..
Yeast   171 KLATMIKFNVAETVKIEEGSRKCF----------------NSQDGLAAITKYLMDD------TKK 213

  Fly   523 D-------NYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMV 580
            |       :...||.|....|.::.      :::..:...|.      |..|..:......:.|:
Yeast   214 DLKIEEIIDKTFALCAASAAISYME------EIISKSSRNLN------AFRKLRIQFEGTENTML 266

  Fly   581 LDATTLSNLRIIGEE-----HSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIR 640
            :|:.|:..|.::..:     .||...||...||.|:|.|.:.:..|..|...|:.|.:|:.||..
Yeast   267 IDSKTVRGLELVENKLDKNGISLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKA 331

  Fly   641 MPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSR---AILFEEKL---------YNK 693
            ....||::|..:..:||.::..:::....:..||    ||.|   .:|.:|.|         .|.
Yeast   332 NDDLLQKLRLEMKSLPDLDKLFSRLLCINHSAIK----PDQRINYVLLLKETLQSVKSLKDALND 392

  Fly   694 QKLQG--FMAVLKGFND--LTKLPTMFHQC-------KTTLLKRITQ----LPESGGSFPDLSKE 743
            |.:|.  .....|.||:  :.::..:.:.|       .::.::.:.|    :........|:|::
Yeast   393 QLIQSRLISETKKIFNNDAIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNGLLDVSRQ 457

  Fly   744 L------QYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRIT 802
            :      ::|...  .|..||..:     .:|..||:|                   |.|..||
Yeast   458 IYKEVKEEFFREV--EDLTAKNKI-----NLDHNYDSA-------------------RGFYLRI- 495

  Fly   803 YFGSDKKRYQLDV---PESHASKANKSYTLEGQTKG--KKPSRRYTTAETRALLKDMQHAEDTRN 862
                .::.:..||   |:...|:..|...:|..|..  ||.:|.....|...||     :|:|
Yeast   496 ----KRQEFTDDVATLPDVFISRTIKKNYIECTTLNIIKKNARLKEVMEEILLL-----SEET-- 549

  Fly   863 MVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEE 927
                  ...|.:|.:.|..:.....:.||.||::.|.. |..::....:|...::     :.:.:
Yeast   550 ------VDELLDKIATHISELFMIAEAVAILDLVCSFT-YNLKENNYTIPIFTNN-----LLIRD 602

  Fly   928 GYHPCAN--ASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCR 990
            ..||...  ...::||.:. .|...:.|.::||.||.|||..:::|.|:.||||:|:.|||....
Yeast   603 SRHPLLEKVLKNFVPNTIS-STKHSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGS 666

  Fly   991 LSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASV 1055
            ..:..|:..|: ..|.:....|.|..|:.|.:..|......:|::|||||||::..||..::.:|
Yeast   667 FPVFKRLHARV-CNDSMELTSSNFGFEMKEMAYFLDDINTETLLILDELGRGSSIADGFCVSLAV 730

  Fly  1056 VNFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENED----NADPTQETVTFLYKYTAG 1116
            ...|...:.....|||:.::.........::..||..::.|::    |...||::|..
Yeast   731 TEHLLRTEATVFLSTHFQDIPKIMSKKPAVSHLHMDAVLLNDNSVKMNYQLTQKSVAI------- 788

  Fly  1117 ACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTK----KEKINA 1177
               ::.|....|....|. ||..||.:...:           ||..|...|||:.    ::.||.
Yeast   789 ---ENSGIRVVKKIFNPD-IIAEAYNIHSLL-----------KIAKARTENEDSNGVVDQKTINQ 838

  Fly  1178 LK---DLLKQLKMC 1188
            :|   :|:..||.|
Yeast   839 MKRIHNLVAILKEC 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	179/855 (21%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	19/114 (17%)
		MutS_III	584..>667	CDD:282977	23/87 (26%)
		MutS_IV	767..859	CDD:282975	21/96 (22%)
		ABC_MSH6_euk	924..1140	CDD:213253	58/221 (26%)
MSH4	NP_116652.1	MutS	1..870	CDD:223327	182/859 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810