Protein Alignment Msh6 and MSH3

DIOPT Version :10

• Sequence 1: NP_648755.1
• Gene: Msh6 / 39654
• FlyBaseID: FBgn0036486
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_010016.2
• Gene: MSH3 / 850454
• SGDID: S000000688
• Length: 1018
• Species: Saccharomyces cerevisiae
• Alignment Length: 1182
• Identity: 288/1182 - (24%)
• Similarity: 480/1182 - (40%)
• Gaps: 280/1182 - (23%)

  Fly    88 KRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPT--- 149
            |:.|:.|...:.|.||...               |.|..:|:....:|   .:|..||.|.|
Yeast    12 KKAVKSELTHKQEQEVAVG---------------NGAGSESICLDTDE---EDNLSSVASTTVTN 58

  Fly   150 ---PKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNL---QSNAKQDASYDDIV 208
               |.|....||   |:.|:|      |...|........|.:||..:   :|:...:|..|:
Yeast    59 DSFPLKGSVSSK---NSKNSE------KTSGTSTTFNDIDFAKKLDRIMKRRSDENVEAEDDE-- 112

  Fly   209 TNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKS 273
                             |..:.|.:|.|..:.|...                |:|..:|...||.
Yeast   113 -----------------EEGEEDFVKKKARKSPTAK----------------LTPLDKQVKDLKM 144

  Fly   274 DNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRG---------------EFAHSGFPEISFDK 323
            .:.|.||..:||..|:.:..||......|....:.|               :||:..||::..:.
Yeast   145 HHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQFAYCSFPDVRLNV 209

  Fly   324 MSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQIT--------NRGTQVFGS 380
            ....||....|||.|||.||..:........|::.|::.::....:.|        .||.::.|
Yeast   210 HLERLVHHNLKVAVVEQAETSAIKKHDPGASKSSVFERKISNVFTKATFGVNSTFVLRGKRILG- 273

  Fly   381 QCKIGPNHQPNYMLAIVEKD--EGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTL-VSHHMP 442
                    ..|.:.|: .:|  :|..::|.:..::.:.|:....|||:.......|.: :.:..|
Yeast   274 --------DTNSIWAL-SRDVHQGKVAKYSLISVNLNNGEVVYDEFEEPNLADEKLQIRIKYLQP 329

  Fly   443 VLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVL 507
            :             :.:|.|                     ..|.|...:::    .|.:.||:
Yeast   330 I-------------EVLVNT---------------------DDLPLHVAKFF----KDISCPLI- 355

  Fly   508 RTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAK----P 568
            ...:.|::       |:...|:|.:.:      |.:|.|.::.:.. :||....:..:.:    |
Yeast   356 HKQEYDLE-------DHVVQAIKVMNE------KIQLSPSLIRLVS-KLYSHMVEYNNEQVMLIP 406

  Fly   569 AVASTL-RRSHMVLDATTLSNLRII---GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIK 629
            ::.|.. .:.||:||..:|.:|.|.   |.:.||...|||..|.||.|:|..|:..|..||..|:
Yeast   407 SIYSPFASKIHMLLDPNSLQSLDIFTHDGGKGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIE 471

  Fly   630 ERQDAIGELIRMPTE----LQEVRALLAPMPDFERNLAQIHLFGN----------KQIKQ-MDHP 679
            ||.||| |.|.....    .:.:..:|...||..|.|.:| ::|.          |||.. :||.
Yeast   472 ERLDAI-ECITSEINNSIFFESLNQMLNHTPDLLRTLNRI-MYGTTSRKEVYFYLKQITSFVDHF 534

  Fly   680 DSRAILFEEKLYNKQKLQGFMAVL--KGFNDLTKLPTMFHQCKTTLLKR-ITQLPESGGSFPDLS 741
            ........|...:.....|..:.|  :.|::|.:|      ..||.|.. :|.:..|.....:..
Yeast   535 KMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNEL------LSTTQLPHFLTMINVSAVMEKNSD 593

  Fly   742 KELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLK-TYLVEQERHFGCRITYFG 805
            |::..|....::|.:  .|:|..|...::......:.:.|:.|.|| .||     :|...:.|..
Yeast   594 KQVMDFFNLNNYDCS--EGIIKIQRESESVRSQLKEELAEIRKYLKRPYL-----NFRDEVDYLI 651

  Fly   806 SDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLA- 869
            ..|.....|:|:... |.|.:          |...|:||..|:.|.:.:::.:|   :::::..
Yeast   652 EVKNSQIKDLPDDWI-KVNNT----------KMVSRFTTPRTQKLTQKLEYYKD---LLIRESEL 702

  Fly   870 --RRLFEKFSNHYDQWKQC------IDCVANLDVLGSLAEYA------GQQMVICVPELVSDADQ 920
              :....|.:..|.:.::.      .||:.:|........|.      |||.:|     ..:|..
Yeast   703 QYKEFLNKITAEYTELRKITLNLAQYDCILSLAATSCNVNYVRPTFVNGQQAII-----AKNARN 762

  Fly   921 PFIQLEEGYHPCANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIP 985
            |.|:..:.:        |:||.:.: :.....::::|||||||||:.:|:|.||.||||||:.:|
Yeast   763 PIIESLDVH--------YVPNDIMM-SPENGKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVP 818

  Fly   986 AASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTA 1050
            |...|||:.:.:.||:||.|||:.|.|||.||:.:...|||:....||:||||:||||.|:||.|
Yeast   819 AEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIA 883

  Fly  1051 IAASVVNFLANLK-C-RTLFSTHY-------HNLIDFFHNDKRITLGHMACMVENEDNADPTQET 1106
            |:.:::.:.:.|. | ..||:||:       ..||..:|.|          .||.:...:... :
Yeast   884 ISYALIKYFSELSDCPLILFTTHFPMLGEIKSPLIRNYHMD----------YVEEQKTGEDWM-S 937

  Fly  1107 VTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTK 1171
            |.||||...|....|||.|.||||.:.:.||.||:.:|:::...::              |||..
Yeast   938 VIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEELRKESI--------------NEDAL 988

  Fly  1172 KEKINALKDLLK 1183
            | ..::||.:||
Yeast   989 K-LFSSLKRILK 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MSCRAMM_ClfA	<94..172	CDD:468110	20/83 (24%)
		MutS	260..1185	CDD:440019	253/1001 (25%)
MSH3	NP_010016.2	PRK05399	130..1012	CDD:235444	253/1018 (25%)