DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH3

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_194284.2	Gene:	MSH3 / 828659	AraportID:	AT4G25540	Length:	1081	Species:	Arabidopsis thaliana

Alignment Length:	1145	Identity:	306/1145 - (26%)
Similarity:	488/1145 - (42%)	Gaps:	215/1145 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 SPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSN--AKQDASYDDIVT 209
            :|.|     ||.....|...|.|:...|:.:|:      :|....:.|.|:  |........:..
plant    14 APKP-----KSPTHEPNPVAESSTPPPKISATV------SFSPSKRKLLSDHLAAASPKKPKLSP 67

  Fly   210 NTSNLDEPVVWP--HQKL--EFLQPDKIKDKEGRRPDHPDYDKSTLHVPE-----KFLNGLSPGV 265
            :|.|   ||..|  ||:.  .||:|.         |:.        :|||     |:    :|..
plant    68 HTQN---PVPDPNLHQRFLQRFLEPS---------PEE--------YVPETSSSRKY----TPLE 108

  Fly   266 RQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELG-FTYMRGEFAHSGFPEISFDKMSTILV 329
            :|...|||...|.||..:||..|..:..||::....|| :.:|...|..:..|....:.....||
plant   109 QQVVELKSKYPDVVLMVEVGYRYRFFGEDAEIAARVLGIYAHMDHNFMTASVPTFRLNFHVRRLV 173

  Fly   330 DRGFKVARVEQTETPDMMTERCKR-------IKA--TKFDKVVAREI---CQITNRGTQVFGSQC 382
            :.|:|:..|:||||..:.:....|       :.|  ||.....|.:|   |    .|.:.|||
plant   174 NAGYKIGVVKQTETAAIKSHGANRTGPFFRGLSALYTKATLEAAEDISGGC----GGEEGFGS-- 232

  Fly   383 KIGPNHQPNYMLAIVE---KDEGT-CS-------RYGVCFIDTSIGDFHLGEFEDDKNCSRLLTL 436
                  |.|:::.:|:   |.|.. |.       |.||..::.|.|:....||.|:...|.|..:
plant   233 ------QSNFLVCVVDERVKSETLGCGIEMSFDVRVGVVGVEISTGEVVYEEFNDNFMRSGLEAV 291

  Fly   437 VSHHMPV-LFLNEKSALSQRTQQIVRTVLGGILKEPVP-------GNGKHACSAEKTLKLLAERY 493
            :....|. |.|.:  .|||:|::.:....|......|.       .||    :|...:..|.|:.
plant   292 ILSLSPAELLLGQ--PLSQQTEKFLVAHAGPTSNVRVERASLDCFSNG----NAVDEVISLCEKI 350

  Fly   494 YAGPGSDDNWPLVLRTMQSDMDHLGL-TPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLY 557
            .||...||. .:.|...:..|..|.: |..:...|.::||.     :..|.|:........||
plant   351 SAGNLEDDK-EMKLEAAEKGMSCLTVHTIMNMPHLTVQALA-----LTFCHLKQFGFERILYQ-- 407

  Fly   558 VPPDQLADAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHH 616
                     ..:..|....:.|.|.|.||..|.::      .|..||...::|..|.:|.|||.|
plant   408 ---------GASFRSLSSNTEMTLSANTLQQLEVVKNNSDGSESGSLFHNMNHTLTVYGSRLLRH 463

  Fly   617 WLCAPSCDVSVIKERQDAIGEL---------IRMPTELQE---VRALLAP--------------- 654
            |:..|.||.::|..|.||:.|:         .::.:||.|   .||:::|
plant   464 WVTHPLCDRNLISARLDAVSEISACMGSHSSSQLSSELVEEGSERAIVSPEFYLVLSSVLTAMSR 528

  Fly   655 MPDFERNLAQIH----------------LFGNKQIKQMD-HPDSRAILFEEKLYNKQKLQGFMAV 702
            ..|.:|.:.:|.                |...|||:::. ..||.....:........|:..::|
plant   529 SSDIQRGITRIFHRTAKATEFIAVMEAILLAGKQIQRLGIKQDSEMRSMQSATVRSTLLRKLISV 593

  Fly   703 LKG---FNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAP 764
            :..   .::..||.:..::........:..|..|...||:|              |.|:..|:..
plant   594 ISSPVVVDNAGKLLSALNKEAAVRGDLLDILITSSDQFPEL--------------AEARQAVLVI 644

  Fly   765 QAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTL 829
            :..:|:       ||....|:|....:|..:..|  ||:.        :::|..  ||...::..
plant   645 REKLDS-------SIASFRKKLAIRNLEFLQVSG--ITHL--------IELPVD--SKVPMNWVK 690

  Fly   830 EGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLD 894
            ...|   |.:.||...|..|.|.::..|.:...:|.:.......:.||.:|..:|..:..:|.||
plant   691 VNST---KKTIRYHPPEIVAGLDELALATEHLAIVNRASWDSFLKSFSRYYTDFKAAVQALAALD 752

  Fly   895 VLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANA---STYIPNGLELGTASEAPLSLL 956
            .|.||:..:..:..: .||.|.|.:...|.::.|.||....   ..::||...|....|. ..::
plant   753 CLHSLSTLSRNKNYV-RPEFVDDCEPVEINIQSGRHPVLETILQDNFVPNDTILHAEGEY-CQII 815

  Fly   957 TGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNET 1021
            |||||||||..:|:|.|:.||||:|:.:||:..:|.::|.:|||:||.|.|..|.||||.||:|.
plant   816 TGPNMGGKSCYIRQVALISIMAQVGSFVPASFAKLHVLDGVFTRMGASDSIQHGRSTFLEELSEA 880

  Fly  1022 SLILKHATCHSLVLLDELGRGTATYDGTAIA-ASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRI 1085
            |.|::..:..|||:||||||||:|:||.||| |::.:.||..:|..||.|||..:.: ..|....
plant   881 SHIIRTCSSRSLVILDELGRGTSTHDGVAIAYATLQHLLAEKRCLVLFVTHYPEIAE-ISNGFPG 944

  Fly  1086 TLG--HMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVE 1148
            ::|  |::.:...:|......:.||:|||...|.|.:|:||..|:||.:|...|:||..::.|:|
plant   945 SVGTYHVSYLTLQKDKGSYDHDDVTYLYKLVRGLCSRSFGFKVAQLAQIPPSCIRRAISMAAKLE 1009

  Fly  1149 AIALQRKITAKIVAATAGNEDTK--KEKINALKDLLKQLK 1186
            |....|:...: :....|:|:.:  :|.|:||.||...||
plant  1010 AEVRARERNTR-MGEPEGHEEPRGAEESISALGDLFADLK 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	2/8 (25%)
		MutS	261..1186	CDD:223327	276/1018 (27%)
		MutS_I	263..375	CDD:279898	34/124 (27%)
		MutS_II	391..508	CDD:282973	33/135 (24%)
		MutS_III	584..>667	CDD:282977	31/131 (24%)
		MutS_IV	767..859	CDD:282975	20/91 (22%)
		ABC_MSH6_euk	924..1140	CDD:213253	90/221 (41%)
MSH3	NP_194284.2	MutS	99..1011	CDD:223327	267/989 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830