DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_192116.1	Gene:	MSH6 / 828147	AraportID:	AT4G02070	Length:	1324	Species:	Arabidopsis thaliana

Alignment Length:	1326	Identity:	434/1326 - (32%)
Similarity:	636/1326 - (47%)	Gaps:	213/1326 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TPTNTLLNYFSKSPAFDKKKLTPSVKTDPDA------------------SKSEKENL---QNQQP 55
            ||.:...|..|.||:....|.||.:..:|.:                  ||.:|..|   |...|
plant    48 TPKSNNPNPKSPSPSPSPPKKTPKLNPNPSSNLPARSPSPGPDTPSPVQSKFKKPLLVIGQTPSP 112

  Fly    56 -------------------------KVKDGKKE-ASKPAAKRKLPISDDEPAS---GQRKRKRIV 91
                                     |..||... ..|...|..:...|.|..|   |:.|.:.:|
plant   113 PQSVVITYGDEVVGKQVRVYWPLDKKWYDGSVTFYDKGEGKHVVEYEDGEEESLDLGKEKTEWVV 177

  Fly    92 QPES-------------------DSEPEMEVTKSEDDFSD-----------------CASDYEP- 119
            ..:|                   ||:.::|:...|:|.||                 |.|:.:.
plant   178 GEKSGDRFNRLKRGASALRKVVTDSDDDVEMGNVEEDKSDGDDSSDEDWGKNVGKEVCESEEDDV 242

  Fly   120 ---DENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLES-TIQ 180
               ||||..::.:....:|.:...|.:   |.|..:.||.|::..:.     ..||.|.:: ||.
plant   243 ELVDENEMDEEELVEEKDEETSKVNRV---SKTDSRKRKTSEVTKSG-----GEKKSKTDTGTIL 299

  Fly   181 LAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPD 245
            ....|:..|..|.:....:.....:|.|.:...|........:|..||..|: :|.:.|||...:
plant   300 KGFKASVVEPAKKIGQADRVVKGLEDNVLDGDALARFGARDSEKFRFLGVDR-RDAKRRRPTDEN 363

  Fly   246 YDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGE 310
            ||..||::|..|:..|:.|.||||..|:.:.|.|:|||:||||||:.|||.||..||...||:||
plant   364 YDPRTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFEMDAHVGAKELDIQYMKGE 428

  Fly   311 FAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGT 375
            ..|.||||.:|......||.:|::|..||||||||.:.:|.|...:.  ||||.||:|.:..:||
plant   429 QPHCGFPEKNFSVNIEKLVRKGYRVLVVEQTETPDQLEQRRKETGSK--DKVVKREVCAVVTKGT 491

  Fly   376 QVFGSQCKIGPNHQPNYMLAIVEKDEGTCS-----RYGVCFIDTSIGDFHLGEFEDDKNCSRLLT 435
            ...|......|:  .:|::|:.|..|...:     .:|||.:|.:.....||:|:||::||.|..
plant   492 LTDGEMLLTNPD--ASYLMALTEGGESLTNPTAEHNFGVCLVDVATQKIILGQFKDDQDCSALSC 554

  Fly   436 LVSHHMPVLFLNEKSALSQRTQQ-IVRTVLGGILKEPVPGNGKHACSAEKTL------------- 486
            |:|...||..:.....||..|:: |||.....::...||.:  ....:|||:
plant   555 LLSEMRPVEIIKPAKVLSYATERTIVRQTRNPLVNNLVPLS--EFWDSEKTIYEVGIIYKRINCQ 617

  Fly   487 ---KLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKV 548
               ...:|....|.||.     .|..|.|::    .|.:.|..|||.|||..|:::.:..|:..:
plant   618 PSSAYSSEGKILGDGSS-----FLPKMLSEL----ATEDKNGSLALSALGGAIYYLRQAFLDESL 673

  Fly   549 LPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCT 607
            |..|:::.....|        .::...:.||||||..|.||.|.      |...:|.:.|:.|.|
plant   674 LRFAKFESLPYCD--------FSNVNEKQHMVLDAAALENLEIFENSRNGGYSGTLYAQLNQCIT 730

  Fly   608 KFGKRLLHHWLCAPSCDVSVIKERQDAI----GELIRMPTELQEVRALLAPMPDFERNLAQIHLF 668
            ..|||||..||..|..:..:|||||||:    ||  .:|..| |.|..|:.:||.||.:|::.
plant   731 ASGKRLLKTWLARPLYNTELIKERQDAVAILRGE--NLPYSL-EFRKSLSRLPDMERLIARMF-- 790

  Fly   669 GNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKT--TLLK-----R 726
              ..|:.......:.:|:|:..  |:::|.|::.|:|      ..||...|.:  .:||     |
plant   791 --SSIEASGRNGDKVVLYEDTA--KKQVQEFISTLRG------CETMAEACSSLRAILKHDTSRR 845

  Fly   727 ITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLV 791
            :..|...|.|.|::|..::||..|||...|..:|.:.|..|.|.|||.|..::.|.|..||.:|.
plant   846 LLHLLTPGQSLPNISSSIKYFKDAFDWVEAHNSGRVIPHEGADEEYDCACKTVEEFESSLKKHLK 910

  Fly   792 EQERHFG-CRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQ 855
            ||.:..| ..|.|....|..|.|:||||.:......|.|   ...||...||.|...:.|||::.
plant   911 EQRKLLGDASINYVTVGKDEYLLEVPESLSGSVPHDYEL---CSSKKGVSRYWTPTIKKLLKELS 972

  Fly   856 HAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLA----EYAGQQMVICVPELVS 916
            .|:..:...||.:::||..:|..|.::|:|.:...|.||||.|||    .|.|   |.|.|.:..
plant   973 QAKSEKESALKSISQRLIGRFCEHQEKWRQLVSATAELDVLISLAFASDSYEG---VRCRPVISG 1034

  Fly   917 DADQ--PFIQLEEGYHPCANA-----STYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLL 974
            ....  |.:......||....     .:::||.:::|.|.:|...|||||||||||||:|:|.|.
plant  1035 STSDGVPHLSATGLGHPVLRGDSLGRGSFVPNNVKIGGAEKASFILLTGPNMGGKSTLLRQVCLA 1099

  Fly   975 VIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDEL 1039
            ||:|||||.:||.:..:|.||:|..|:||:|.|:||.||||.||:||:::|..||.:|||:||||
plant  1100 VILAQIGADVPAETFEVSPVDKICVRMGAKDHIMAGQSTFLTELSETAVMLTSATRNSLVVLDEL 1164

  Fly  1040 GRGTATYDGTAIAASVV-NFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPT 1103
            ||||||.||.|||.||: :|:..::||..||||||.|...:..:.:::|.||||.:......
plant  1165 GRGTATSDGQAIAESVLEHFIEKVQCRGFFSTHYHRLSVDYQTNPKVSLCHMACQIGEGIGG--- 1226

  Fly  1104 QETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAI------ALQRKITA---K 1159
            .|.|||||:.|.||||||||.|.|:|||:|..:::||...|::.||:      ....|:.|   :
plant  1227 VEEVTFLYRLTPGACPKSYGVNVARLAGLPDYVLQRAVIKSQEFEALYGKNHRKTDHKLAAMIKQ 1291

  Fly  1160 IVAATAGNEDTKKEKINALKDLLKQL 1185
            |:::.|.:.|     .:|.||.|.:|
plant  1292 IISSVASDSD-----YSASKDSLCEL 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	35/183 (19%)
		MutS	261..1186	CDD:223327	361/986 (37%)
		MutS_I	263..375	CDD:279898	55/111 (50%)
		MutS_II	391..508	CDD:282973	35/138 (25%)
		MutS_III	584..>667	CDD:282977	36/92 (39%)
		MutS_IV	767..859	CDD:282975	34/92 (37%)
		ABC_MSH6_euk	924..1140	CDD:213253	110/221 (50%)
MSH6	NP_192116.1	TUDOR	124..175	CDD:383034	10/50 (20%)
MSH6	NP_192116.1	MutS	376..1297	CDD:223327	354/967 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	201	1.000	Domainoid score	I870
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	568	1.000	Inparanoid score	I243
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto3214
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840