Protein Alignment Msh6 and MSH6

DIOPT Version :10

• Sequence 1: NP_648755.1
• Gene: Msh6 / 39654
• FlyBaseID: FBgn0036486
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_192116.1
• Gene: MSH6 / 828147
• AraportID: AT4G02070
• Length: 1324
• Species: Arabidopsis thaliana
• Alignment Length: 1326
• Identity: 434/1326 - (32%)
• Similarity: 636/1326 - (47%)
• Gaps: 213/1326 - (16%)

  Fly    12 TPTNTLLNYFSKSPAFDKKKLTPSVKTDPDA------------------SKSEKENL---QNQQP 55
            ||.:...|..|.||:....|.||.:..:|.:                  ||.:|..|   |...|
plant    48 TPKSNNPNPKSPSPSPSPPKKTPKLNPNPSSNLPARSPSPGPDTPSPVQSKFKKPLLVIGQTPSP 112

  Fly    56 -------------------------KVKDGKKE-ASKPAAKRKLPISDDEPAS---GQRKRKRIV 91
                                     |..||... ..|...|..:...|.|..|   |:.|.:.:|
plant   113 PQSVVITYGDEVVGKQVRVYWPLDKKWYDGSVTFYDKGEGKHVVEYEDGEEESLDLGKEKTEWVV 177

  Fly    92 QPES-------------------DSEPEMEVTKSEDDFSD-----------------CASDYEP- 119
            ..:|                   ||:.::|:...|:|.||                 |.|:.:.
plant   178 GEKSGDRFNRLKRGASALRKVVTDSDDDVEMGNVEEDKSDGDDSSDEDWGKNVGKEVCESEEDDV 242

  Fly   120 ---DENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLES-TIQ 180
               ||||..::.:....:|.:...|.:   |.|..:.||.|::..:.     ..||.|.:: ||.
plant   243 ELVDENEMDEEELVEEKDEETSKVNRV---SKTDSRKRKTSEVTKSG-----GEKKSKTDTGTIL 299

  Fly   181 LAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPD 245
            ....|:..|..|.:....:.....:|.|.:...|........:|..||..|: :|.:.|||...:
plant   300 KGFKASVVEPAKKIGQADRVVKGLEDNVLDGDALARFGARDSEKFRFLGVDR-RDAKRRRPTDEN 363

  Fly   246 YDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGE 310
            ||..||::|..|:..|:.|.||||..|:.:.|.|:|||:||||||:.|||.||..||...||:||
plant   364 YDPRTLYLPPDFVKKLTGGQRQWWEFKAKHMDKVVFFKMGKFYELFEMDAHVGAKELDIQYMKGE 428

  Fly   311 FAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGT 375
            ..|.||||.:|......||.:|::|..||||||||.:.:|.|...:.  ||||.||:|.:..:||
plant   429 QPHCGFPEKNFSVNIEKLVRKGYRVLVVEQTETPDQLEQRRKETGSK--DKVVKREVCAVVTKGT 491

  Fly   376 QVFGSQCKIGPNHQPNYMLAIVEKDEGTCS-----RYGVCFIDTSIGDFHLGEFEDDKNCSRLLT 435
            ...|......|:  .:|::|:.|..|...:     .:|||.:|.:.....||:|:||::||.|..
plant   492 LTDGEMLLTNPD--ASYLMALTEGGESLTNPTAEHNFGVCLVDVATQKIILGQFKDDQDCSALSC 554

  Fly   436 LVSHHMPVLFLNEKSALSQRTQQ-IVRTVLGGILKEPVPGNGKHACSAEKTL------------- 486
            |:|...||..:.....||..|:: |||.....::...||.:  ....:|||:
plant   555 LLSEMRPVEIIKPAKVLSYATERTIVRQTRNPLVNNLVPLS--EFWDSEKTIYEVGIIYKRINCQ 617

  Fly   487 ---KLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKV 548
               ...:|....|.||.     .|..|.|::    .|.:.|..|||.|||..|:::.:..|:..:
plant   618 PSSAYSSEGKILGDGSS-----FLPKMLSEL----ATEDKNGSLALSALGGAIYYLRQAFLDESL 673

  Fly   549 LPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCT 607
            |..|:::.....|        .::...:.||||||..|.||.|.      |...:|.:.|:.|.|
plant   674 LRFAKFESLPYCD--------FSNVNEKQHMVLDAAALENLEIFENSRNGGYSGTLYAQLNQCIT 730

  Fly   608 KFGKRLLHHWLCAPSCDVSVIKERQDAI----GELIRMPTELQEVRALLAPMPDFERNLAQIHLF 668
            ..|||||..||..|..:..:|||||||:    ||  .:|..| |.|..|:.:||.||.:|::.
plant   731 ASGKRLLKTWLARPLYNTELIKERQDAVAILRGE--NLPYSL-EFRKSLSRLPDMERLIARMF-- 790

  Fly   669 GNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKT--TLLK-----R 726
              ..|:.......:.:|:|:..  |:::|.|::.|:|      ..||...|.:  .:||     |
plant   791 --SSIEASGRNGDKVVLYEDTA--KKQVQEFISTLRG------CETMAEACSSLRAILKHDTSRR 845

  Fly   727 ITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLV 791
            :..|...|.|.|::|..::||..|||...|..:|.:.|..|.|.|||.|..::.|.|..||.:|.
plant   846 LLHLLTPGQSLPNISSSIKYFKDAFDWVEAHNSGRVIPHEGADEEYDCACKTVEEFESSLKKHLK 910

  Fly   792 EQERHFG-CRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQ 855
            ||.:..| ..|.|....|..|.|:||||.:......|.|   ...||...||.|...:.|||::.
plant   911 EQRKLLGDASINYVTVGKDEYLLEVPESLSGSVPHDYEL---CSSKKGVSRYWTPTIKKLLKELS 972

  Fly   856 HAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLA----EYAGQQMVICVPELVS 916
            .|:..:...||.:::||..:|..|.::|:|.:...|.||||.|||    .|.|   |.|.|.:..
plant   973 QAKSEKESALKSISQRLIGRFCEHQEKWRQLVSATAELDVLISLAFASDSYEG---VRCRPVISG 1034

  Fly   917 DADQ--PFIQLEEGYHPCANA-----STYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLL 974
            ....  |.:......||....     .:::||.:::|.|.:|...|||||||||||||:|:|.|.
plant  1035 STSDGVPHLSATGLGHPVLRGDSLGRGSFVPNNVKIGGAEKASFILLTGPNMGGKSTLLRQVCLA 1099

  Fly   975 VIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDEL 1039
            ||:|||||.:||.:..:|.||:|..|:||:|.|:||.||||.||:||:::|..||.:|||:||||
plant  1100 VILAQIGADVPAETFEVSPVDKICVRMGAKDHIMAGQSTFLTELSETAVMLTSATRNSLVVLDEL 1164

  Fly  1040 GRGTATYDGTAIAASVV-NFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPT 1103
            ||||||.||.|||.||: :|:..::||..||||||.|...:..:.:::|.||||.:......
plant  1165 GRGTATSDGQAIAESVLEHFIEKVQCRGFFSTHYHRLSVDYQTNPKVSLCHMACQIGEGIGG--- 1226

  Fly  1104 QETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAI------ALQRKITA---K 1159
            .|.|||||:.|.||||||||.|.|:|||:|..:::||...|::.||:      ....|:.|   :
plant  1227 VEEVTFLYRLTPGACPKSYGVNVARLAGLPDYVLQRAVIKSQEFEALYGKNHRKTDHKLAAMIKQ 1291

  Fly  1160 IVAATAGNEDTKKEKINALKDLLKQL 1185
            |:::.|.:.|     .:|.||.|.:|
plant  1292 IISSVASDSD-----YSASKDSLCEL 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MSCRAMM_ClfA	<94..172	CDD:468110	21/117 (18%)
		MutS	260..1185	CDD:440019	360/985 (37%)
MSH6	NP_192116.1	Tudor_Agenet_AtEML-like	125..175	CDD:410475	10/49 (20%)
		MutS	377..1263	CDD:440019	346/932 (37%)