DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH7

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_850630.1	Gene:	MSH7 / 822040	AraportID:	AT3G24495	Length:	1109	Species:	Arabidopsis thaliana

Alignment Length:	1278	Identity:	366/1278 - (28%)
Similarity:	550/1278 - (43%)	Gaps:	318/1278 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TLLNYFSKSPAFDKKKLTP---------------SVKTDPDA----------SKSEKENLQNQQP 55
            ::|::|.|..|...|.|..               :|| :.||          |||..|......|
plant     6 SILSFFQKPTAATTKGLVSGDAASGGGGSGGPRFNVK-EGDAKGDASVRFAVSKSVDEVRGTDTP 69

  Fly    56 KVKDGKK---EASKPAAK------------RKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTK 105
            ..|..::   ...|||..            .|....||...||:|.|:.:| |.:||...|:.
plant    70 PEKVPRRVLPSGFKPAESAGDASSLFSNIMHKFVKVDDRDCSGERSREDVV-PLNDSSLCMKA-- 131

  Fly   106 SEDDFSDCASDYEPDENEASDDSVS---SGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNE 167
                 :|....:..:..:..:.:.:   ||..|:. |..|:.||...|.......:
plant   132 -----NDVIPQFRSNNGKTQERNHAFSFSGRAELR-SVEDIGVDGDVPGPETPGMR--------- 181

  Fly   168 PSSKKVKLESTIQLAEGATFQE-KLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPD 231
            |.:.::|.    .|.:..||:| |:..|.||.:.....|.:......::|..     |.|:|:..
plant   182 PRASRLKR----VLEDEMTFKEDKVPVLDSNKRLKMLQDPVCGEKKEVNEGT-----KFEWLESS 237

  Fly   232 KIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDAD 296
            :|:|...||||.|.||:.|||:|......:|...:|:|.:||:..|.|||||||||||||.:||:
plant   238 RIRDANRRRPDDPLYDRKTLHIPPDVFKKMSASQKQYWSVKSEYMDIVLFFKVGKFYELYELDAE 302

  Fly   297 VGVNELGFTYMR---GEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATK 358
            :|..||.:....   |:....|..|...|:....|:.||:||.|:||.||.|       :.||..
plant   303 LGHKELDWKMTMSGVGKCRQVGISESGIDEAVQKLLARGYKVGRIEQLETSD-------QAKARG 360

  Fly   359 FDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAI--VEKDEGTCSR-YGVCFIDTSIGDFH 420
            .:.::.|::.|:....|   .|:..|||:  ..::|||  ::.:...||. ||..|:|.:...|.
plant   361 ANTIIPRKLVQVLTPST---ASEGNIGPD--AVHLLAIKEIKMELQKCSTVYGFAFVDCAALRFW 420

  Fly   421 LGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVR--TVLG--GILKEPVPGNGKHACS 481
            :|...||.:|:.|..|:....|...|.:...||:..|:.:|  |:.|  .:...|||
plant   421 VGSISDDASCAALGALLMQVSPKEVLYDSKGLSREAQKALRKYTLTGSTAVQLAPVP-------- 477

  Fly   482 AEKTLKLLAERYYAG-----------PGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQC 535
                 :::.:...||           .||.::|...:.         ||...|   :||.|||:.
plant   478 -----QVMGDTDAAGVRNIIESNGYFKGSSESWNCAVD---------GLNECD---VALSALGEL 525

  Fly   536 IFFIHKCKLEP-----KVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRII--- 592
            |..:.:.|||.     .:.|   ||:|                  |..:.:|..|:.||.|.
plant   526 INHLSRLKLEDVLKHGDIFP---YQVY------------------RGCLRIDGQTMVNLEIFNNS 569

  Fly   593 ---GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAP 654
               |...:|...||:|.:..|||||.:|:|.|..||..|.:|.|.:.|.......:|.....|..
plant   570 CDGGPSGTLYKYLDNCVSPTGKRLLRNWICHPLKDVESINKRLDVVEEFTANSESMQITGQYLHK 634

  Fly   655 MPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFND-------LTKL 712
            :||.||.|.:|     |...:.......|:|.::.|  ||:::.|..::|||..       |.|.
plant   635 LPDLERLLGRI-----KSSVRSSASVLPALLGKKVL--KQRVKAFGQIVKGFRSGIDLLLALQKE 692

  Fly   713 PTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMD---AEYDA 774
            ..|.     :||.::.:||                             ::..::|::   ::::|
plant   693 SNMM-----SLLYKLCKLP-----------------------------ILVGKSGLELFLSQFEA 723

  Fly   775 AMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPS 839
            |:|                            ||...||           |:..|.|
plant   724 AID----------------------------SDFPNYQ-----------NQDVTDE--------- 740

  Fly   840 RRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAG 904
                .|||..:                     |.|.|.....||.:.|..::.||||.|.|..|.
plant   741 ----NAETLTI---------------------LIELFIERATQWSEVIHTISCLDVLRSFAIAAS 780

  Fly   905 ------QQMVICVPELVSDADQ----PFIQLEEGYHP---CANASTYIPNGLELGTASEA----- 951
                  .:.||......:|.:|    |.::::..:||   .|:....:||.:.||.|..:
plant   781 LSAGSMARPVIFPESEATDQNQKTKGPILKIQGLWHPFAVAADGQLPVPNDILLGEARRSSGSIH 845

  Fly   952 PLS-LLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFL 1015
            |.| |||||||||||||:|...|.||.||:|.::|..||.:||||.|||||||.|.|:.|.||||
plant   846 PRSLLLTGPNMGGKSTLLRATCLAVIFAQLGCYVPCESCEISLVDTIFTRLGASDRIMTGESTFL 910

  Fly  1016 VELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLA-NLKCRTLFSTHYHNLIDFF 1079
            ||..||:.:|::||..|||:||||||||:|:||.|||.||...|. .::||.||:||||.|...|
plant   911 VECTETASVLQNATQDSLVILDELGRGTSTFDGYAIAYSVFRHLVEKVQCRMLFATHYHPLTKEF 975

  Fly  1080 HNDKRITLGHMACMVENEDNADP--TQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYE 1142
            .:..|:|..||||..::..:..|  ..:.:.|||:.|.||||:|||...|.:||:|..:::.|
plant   976 ASHPRVTSKHMACAFKSRSDYQPRGCDQDLVFLYRLTEGACPESYGLQVALMAGIPNQVVETA-- 1038

  Fly  1143 LSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQL 1185
               ...|.|::|.|.....::     :.:.|..:..:|.||.|
plant  1039 ---SGAAQAMKRSIGENFKSS-----ELRSEFSSLHEDWLKSL 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	29/129 (22%)
		MutS	261..1186	CDD:223327	298/989 (30%)
		MutS_I	263..375	CDD:279898	42/114 (37%)
		MutS_II	391..508	CDD:282973	32/134 (24%)
		MutS_III	584..>667	CDD:282977	31/88 (35%)
		MutS_IV	767..859	CDD:282975	14/94 (15%)
		ABC_MSH6_euk	924..1140	CDD:213253	110/227 (48%)
MSH7	NP_850630.1	MutS	264..1070	CDD:223327	295/987 (30%)
		MutS_I	271..382	CDD:279898	44/120 (37%)
		MutS_II	389..540	CDD:282973	44/175 (25%)
		MutS_III	558..776	CDD:282977	73/331 (22%)
		ABC_MSH6_euk	810..1038	CDD:213253	110/227 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	201	1.000	Domainoid score	I870
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11361
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.890