DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH1

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_189075.2	Gene:	MSH1 / 822021	AraportID:	AT3G24320	Length:	1118	Species:	Arabidopsis thaliana

Alignment Length:	1154	Identity:	271/1154 - (23%)
Similarity:	423/1154 - (36%)	Gaps:	307/1154 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPV 218
            :..|.||.|...:|..|         .|.:|    :.||.:.:.:|:..:..|::|: .:|.. :
plant    31 KPSSPILLNRRYSEGIS---------CLRDG----KSLKRITTASKKVKTSSDVLTD-KDLSH-L 80

  Fly   219 VWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKF----LNGLSPGVR---------QWWV 270
            ||..::|:..          ::|       |||.:.|:.    |.||.|.:|         .|.:
plant    81 VWWKERLQTC----------KKP-------STLQLIERLMYTNLLGLDPSLRNGSLKDGNLNWEM 128

  Fly   271 L--KSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRG----EFAHSGFPEISFDKMSTILV 329
            |  ||.....||..:||:|||...:||.:.|...|.....|    ....:|.|.::..:....|.
plant   129 LQFKSRFPREVLLCRVGEFYEAIGIDACILVEYAGLNPFGGLRSDSIPKAGCPIMNLRQTLDDLT 193

  Fly   330 DRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGT-QVFGSQCKIGPNH----- 388
            ..|:.|..||:.:.|.....|            ..|.|....:.|: .|:|   .:|.:|
plant   194 RNGYSVCIVEEVQGPTPARSR------------KGRFISGHAHPGSPYVYG---LVGVDHDLDFP 243

  Fly   389 QPNYMLAIVEKDEGTCSRYGVCFIDT----SIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEK 449
            .|..::.|.....|.|.   :...:|    |:.|    ...::...::|.|...||   |||:..
plant   244 DPMPVVGISRSARGYCM---ISIFETMKAYSLDD----GLTEEALVTKLRTRRCHH---LFLHAS 298

  Fly   450 SALSQRTQQIVRTVLGGILKEPVPGNGK---HACSAEK-------TLKLLAERYYAGPGSDDN-- 502
                      :|....|..:....|.|.   ..||:..       ||..|..|.....|.||.
plant   299 ----------LRHNASGTCRWGEFGEGGLLWGECSSRNFEWFEGDTLSELLSRVKDVYGLDDEVS 353

  Fly   503 ------------WPLVLRTMQSDMDHLGLTPNDNYKLALKAL------GQCIFFIHKCKLEPKVL 549
                        .||.|.|    ...:|..|.:.....||.|      |....::....|.|
plant   354 FRNVNVPSKNRPRPLHLGT----ATQIGALPTEGIPCLLKVLLPSTCSGLPSLYVRDLLLNP--- 411

  Fly   550 PMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRIIGEEHSLLSTLDHCCTKFGKRLL 614
                              ||....|:                |.|...|:||:  .|:      :
plant   412 ------------------PAYDIALK----------------IQETCKLMSTV--TCS------I 434

  Fly   615 HHWLCAPSCDVSVIKERQDA-----------IGELIRM--PTELQEVRALLAPMP--------DF 658
            ..:.|..|..:..:.|:::|           :.:::.|  ..||.|:..||....        ||
plant   435 PEFTCVSSAKLVKLLEQREANYIEFCRIKNVLDDVLHMHRHAELVEILKLLMDPTWVATGLKIDF 499

  Fly   659 ERNLAQIHLFGNKQIKQM---DHPDSRAILFE------EKLYNKQKLQGFMAVLKGFNDLTKLPT 714
            :..:.:.| :.:..|.:|   |..:|...:.:      |..|:.:  ..:...:||.:
plant   500 DTFVNECH-WASDTIGEMISLDENESHQNVSKCDNVPNEFFYDME--SSWRGRVKGIH------- 554

  Fly   715 MFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFD-HDAAAKTGVIAPQAGMDAEYDAAMDS 778
                    :.:.|||:.:|.        |....|.|.| |...::........|         ..
plant   555 --------IEEEITQVEKSA--------EALSLAVAEDFHPIISRIKATTASLG---------GP 594

  Fly   779 IGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQ----TKGKKPS 839
            .||:     .|..|.|     .:.:.|   ||:   .|...|..|.:....:.:    :||||..
plant   595 KGEI-----AYAREHE-----SVWFKG---KRF---TPSIWAGTAGEDQIKQLKPALDSKGKKVG 643

  Fly   840 RR-YTTAETR-ALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEY 902
            .. :||.:.. ||::..:.:|:.:..|| :|.|.|..|.     |.|..:...|::.::.|.|.:
plant   644 EEWFTTPKVEIALVRYHEASENAKARVL-ELLRELSVKL-----QTKINVLVFASMLLVISKALF 702

  Fly   903 A----GQQMVICVPELVSDADQPFIQLEEGYHPCANASTYIPNGL-------ELGTA-----SEA 951
            :    |::.....|.||.      ..|:||..|...||.....||       ..|||     ...
plant   703 SHACEGRRRKWVFPTLVG------FSLDEGAKPLDGASRMKLTGLSPYWFDVSSGTAVHNTVDMQ 761

  Fly   952 PLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLV 1016
            .|.||||||.||||:|:|.:....::...|..:||.|..:...|.|...:.:.|..:.|.|:|.|
plant   762 SLFLLTGPNGGGKSSLLRSICAAALLGISGLMVPAESACIPHFDSIMLHMKSYDSPVDGKSSFQV 826

  Fly  1017 ELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHN 1081
            |::|...|:..||..||||:||:.|||.|..||.||.|||..|....|..:.|||.|.:......
plant   827 EMSEIRSIVSQATSRSLVLIDEICRGTETAKGTCIAGSVVESLDTSGCLGIVSTHLHGIFSLPLT 891

  Fly  1082 DKRITLGHMACMVEN-EDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSK 1145
            .|.||  :.|...|| |....||       :|.|.|.|.:|..|..||..|:|:.:|:||..|..
plant   892 AKNIT--YKAMGAENVEGQTKPT-------WKLTDGVCRESLAFETAKREGVPESVIQRAEALYL 947

  Fly  1146 KVEAIALQRKITAKIVAATAGNEDTKKEK-----INALKDLLKQL-KMC 1188
            .|.|.....::.......|:.|.|.:.:|     .:..|||.|.: |:|
plant   948 SVYAKDASAEVVKPDQIITSSNNDQQIQKPVSSERSLEKDLAKAIVKIC 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	0/1 (0%)
		MutS	261..1186	CDD:223327	245/1039 (24%)
		MutS_I	263..375	CDD:279898	29/126 (23%)
		MutS_II	391..508	CDD:282973	28/144 (19%)
		MutS_III	584..>667	CDD:282977	18/103 (17%)
		MutS_IV	767..859	CDD:282975	20/97 (21%)
		ABC_MSH6_euk	924..1140	CDD:213253	83/228 (36%)
MSH1	NP_189075.2	MutS_I	128..226	CDD:396271	26/109 (24%)
		ABC_MutS_homologs	748..934	CDD:213210	72/194 (37%)
		GIY-YIG_MSH	1025..1094	CDD:198385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820