DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH5

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_188683.3	Gene:	MSH5 / 821593	AraportID:	AT3G20475	Length:	807	Species:	Arabidopsis thaliana

Alignment Length:	869	Identity:	201/869 - (23%)
Similarity:	337/869 - (38%)	Gaps:	209/869 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 QPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEF-EDDKNCSRLLTLVSHHM--PVLFLNEKS 450
            :|...:|.::...    |.||.:.|.|:...|:.|| |:|.:...|:.:|.:..  .:::.:.||
plant    10 EPQVYMACIQHGR----RVGVSYYDCSVRQLHVLEFWEEDCSDFTLINMVKYQAKPSIIYASTKS 70

  Fly   451 -----ALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRT- 509
                 |..|:......|.:..::|       ....|.|:....|.  |....|.||...:..|.
plant    71 EESFVAALQQNDGTDETTMVKLVK-------SSTFSYEQAWHRLV--YLRVTGMDDGLNIKERIC 126

  Fly   510 -MQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVAST 573
             :.|.|| :|      .::.::..|..:          .:|...|....:..::...|..|:.|.
plant   127 YLSSMMD-VG------SEVQVRVSGGLL----------AILESERIVETLEQNESGSASIAIDSV 174

  Fly   574 LR---RSHMVLDATTLSNLRI-----------IG---EEHSLLSTLDHCCTKFGKRLLHHWLCAP 621
            :.   ...:.|||.....|:|           ||   |..|:...::.|.|..|:|||..|...|
plant   175 MEVPLNKFLKLDAAAHEALQIFQTDKHPSHMGIGRAKEGFSVFGMMNKCATPMGRRLLRSWFMRP 239

  Fly   622 SCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILF 686
            ..|:.|:..|.:||...|.....:..:|..|                  |.:|.:.|
plant   240 ILDLEVLDRRLNAISFFISSVELMASLRETL------------------KSVKDISH-------- 278

  Fly   687 EEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFP-DLSKELQYFATA 750
                           :||.||..|.|.|  ....|..||.|:.|......|. .:|:.|:.....
plant   279 ---------------LLKKFNSPTSLCT--SNDWTAFLKSISALLHVNKIFEVGVSESLREHMRR 326

  Fly   751 FDHDAAAKTGVIAPQAGMDAEYD-------------------------AAMDSIGEVEKRLKTYL 790
            |:.|...|.| :.....:|..|:                         |.:|.:.::.:.|..:|
plant   327 FNLDIIEKAG-LCISTELDYVYELVIGVIDVTRSKERGYQTLVKEGFCAELDELRQIYEELPEFL 390

  Fly   791 VE----QERHF------------------GCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQT 833
            .|    :..||                  |..:..||.     :||  |:..::..:........
plant   391 QEVSAMELEHFPHLHKEKLPPCIVYIQQIGYLMCIFGE-----KLD--ETALNRLTEFEFAFSDM 448

  Fly   834 KGKKPSRRYTTAETRA---LLKDMQH-AEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLD 894
            .|:.....|.|::||.   ||.|:.| ..|....:::||..... .||.|.   .:.::.||.||
plant   449 DGETQRFFYHTSKTRELDNLLGDIYHKILDMERAIIRDLLSHTL-LFSAHL---LKAVNFVAELD 509

  Fly   895 VLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCAN--ASTYIPNGLELGTASEAPLSLLT 957
            .:.|||..|.|...: .|.|..::   .:.:..|.|....  ..|:|||..|:.  ....:.::|
plant   510 CILSLACVAHQNNYV-RPVLTVES---LLDIRNGRHVLQEMAVDTFIPNDTEIN--DNGRIHIIT 568

  Fly   958 GPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETS 1022
            |||..|||..:::|.|:|.::.||:.:||.:..:.|.||||..:|:: .:.|..|||:::|::..
plant   569 GPNYSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIFCAMGSK-FMTAEQSTFMIDLHQVG 632

  Fly  1023 LILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLANLKC----RTLFSTHYHNLIDFFHNDK 1083
            ::|:.||..||.||||.|:||.|.||..:....::..|.  |    |.:..||...|:
plant   633 MMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISHFAT--CAEPPRVVVCTHLTELL------- 688

  Fly  1084 RITLGHMACMVENE------------DNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGI 1136
                 :.:|:..:|            |......|.:.|||:...|....|||.:.|.|||:|:.:
plant   689 -----NESCLPVSEKIKFYTMSVLRPDTESANMEEIVFLYRLIPGQTLLSYGLHCALLAGVPEEV 748

  Fly  1137 IKR------AYELSKKVEAIALQR 1154
            :||      |:|.:..|:.::|.:
plant   749 VKRAAIVLDAFESNNNVDKLSLDK 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	201/869 (23%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	26/124 (21%)
		MutS_III	584..>667	CDD:282977	22/96 (23%)
		MutS_IV	767..859	CDD:282975	24/142 (17%)
		ABC_MSH6_euk	924..1140	CDD:213253	71/239 (30%)
MSH5	NP_188683.3	MutS	12..793	CDD:223327	200/867 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820