DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH2

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_566804.3	Gene:	MSH2 / 821383	AraportID:	AT3G18524	Length:	937	Species:	Arabidopsis thaliana

Alignment Length:	846	Identity:	219/846 - (25%)
Similarity:	348/846 - (41%)	Gaps:	194/846 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 EGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLG 465
            :|.|. .|:.::|.:.....|.||.||..               |.|.:|:|         ..||
plant   153 DGRCV-IGMAYVDLTRRVLGLAEFLDDSR---------------FTNLESSL---------IALG 192

  Fly   466 GILKE---PVPGNGKHAC-----SAEKTLKLLAER---YYAGPGSDDNWPLVLRTMQSDMDHL-- 517
            .  ||   |......:.|     |.|:...::.||   .:.|           |.:.||:..|
plant   193 A--KECIFPAESGKSNECKSLYDSLERCAVMITERKKHEFKG-----------RDLDSDLKRLVK 244

  Fly   518 -GLTP----NDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRR- 576
             .:.|    ...:.||..|||..:.|               .:|....|...:      .|:||
plant   245 GNIEPVRDLVSGFDLATPALGALLSF---------------SELLSNEDNYGN------FTIRRY 288

  Fly   577 ---SHMVLDATTLSNLRII------GEEHSLLSTLDHCCTK-FGKRLLHHWLCAPSCDVSVIKER 631
               ..|.||:..:..|.::      .:..||...::..||. .||||||.||..|..|::.||.|
plant   289 DIGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNEIKTR 353

  Fly   632 QDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKL 696
            .|.:...:......|::|..|..:.|.||.|..:                           :::.
plant   354 LDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSL---------------------------ERRR 391

  Fly   697 QGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKE--LQYFATAFDHDAAAK- 758
            .|...::|.:....:||         .:|  |.:.:..|.|..|..|  |:......|.|...|
plant   392 GGLQHIIKLYQSTIRLP---------FIK--TAMQQYTGEFASLISERYLKKLEALSDQDHLGKF 445

  Fly   759 TGVIAPQAGMD----------AEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSD---KKR 810
            ..::.....:|          :.||..:.|:.:.::     |:||:.|...:.|....|   .|.
plant   446 IDLVECSVDLDQLENGEYMISSSYDTKLASLKDQKE-----LLEQQIHELHKKTAIELDLQVDKA 505

  Fly   811 YQLD----------VPESHASKANKSYT-----LEGQTKGKKPSRRYTTAETRALLKDMQHAEDT 860
            .:||          :.:....|..|..|     ||.:..|.|    :|..:.:.|....|...|.
plant   506 LKLDKAAQFGHVFRITKKEEPKIRKKLTTQFIVLETRKDGVK----FTNTKLKKLGDQYQSVVDD 566

  Fly   861 RNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQ-QMVICVPELVSDADQPFIQ 924
            .....|:|..|:.|..::..:.::.....::.:|||.|.|:.|.. ....|.||:.| :|...|.
plant   567 YRSCQKELVDRVVETVTSFSEVFEDLAGLLSEMDVLLSFADLAASCPTPYCRPEITS-SDAGDIV 630

  Fly   925 LEEGYHPCANAS---TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPA 986
            ||...|||..|.   .:|||...| ...::...::||||||||||.:|:||::|:|||:|:.:|.
plant   631 LEGSRHPCVEAQDWVNFIPNDCRL-MRGKSWFQIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPC 694

  Fly   987 ASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAI 1051
            ....:|:.|.||.|:||.|..|.|.|||:.|:.||:.|||.|:..||:::|||||||:||||..:
plant   695 DKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSLIIIDELGRGTSTYDGFGL 759

  Fly  1052 AASVVNFLANLK-CRTLFSTHYHNLIDFFHNDKRI---TLG----HMACMVENEDNADPTQETVT 1108
            |.::...|..:| ..|||:||:|.|......:..:   |:|    |::..::.|      ...:|
plant   760 AWAICEHLVQVKRAPTLFATHFHELTALAQANSEVSGNTVGVANFHVSAHIDTE------SRKLT 818

  Fly  1109 FLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKE 1173
            .|||...|||.:|:|.:.|:.|..|:.::..|.|.:.::|..:....|        ..||::.|.
plant   819 MLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELEDFSPSSMI--------INNEESGKR 875

  Fly  1174 K 1174
            |
plant   876 K 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	219/846 (26%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	24/117 (21%)
		MutS_III	584..>667	CDD:282977	26/89 (29%)
		MutS_IV	767..859	CDD:282975	23/119 (19%)
		ABC_MSH6_euk	924..1140	CDD:213253	88/226 (39%)
MSH2	NP_566804.3	MutS	37..898	CDD:223327	219/846 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820