DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msh6 and Msh2

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_112320.2	Gene:	Msh2 / 81709	RGDID:	620786	Length:	933	Species:	Rattus norvegicus

Alignment Length:	1008	Identity:	238/1008 - (23%)
Similarity:	411/1008 - (40%)	Gaps:	229/1008 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 VLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTET 343
            |..|..|.||..:..||.:...|:..|  :|...:.| |..:....:.:|....|      ::..
  Rat    34 VRLFDRGDFYTAHGEDALLAAREVFKT--QGVIKYMG-PAGAKTLQTVVLSKMNF------ESFV 89

  Fly   344 PDMMTERCKRI---------KATKFD------KVVAREICQITNRGTQVFGSQCKIGPNHQPNYM 393
            .|::..|..|:         ||:|.:      |.....:.|..:   .:||       |:..:..
  Rat    90 KDLLLVRHYRVEVYKNKAGNKASKENDWYLAYKASPGNLSQFED---ILFG-------NNDMSTS 144

  Fly   394 LAIVEKDEGTCS---RYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMP---VLFLNEKSAL 452
            :.|:.....|..   :.||.::|::.....|.||.|:...|.|..|:....|   :|...|.:..
  Rat   145 IGIMGIKLSTVDGQRQVGVGYVDSTQRKLGLCEFPDNDQFSNLEALLIQIGPKECILPGGETAGD 209

  Fly   453 SQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHL 517
            ..:.:|:::.  ||||           .:..|.:....:..|    .|.|  .:|:..:.:..:.
  Rat   210 MGKLRQVIQR--GGIL-----------ITERKRIDFSTKDIY----QDLN--RLLKGRKGEQMNS 255

  Fly   518 GLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLAD----AKPAVASTLRRSH 578
            .:.|....::|:.:|...|.|:                     :.|:|    .:..:|:.....:
  Rat   256 AVLPEMENQVAVSSLSAVIKFL---------------------ELLSDDSNFGQFELATFDFSQY 299

  Fly   579 MVLDATTLSNLRII--------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAI 635
            |.||...:..|.:.        |.: ||.:.|:.|.|..|:||:..|:..|..|.:.|:||.:.:
  Rat   300 MKLDMAAVRALNLFQGSVEDTTGSQ-SLAALLNKCKTAQGQRLVSQWIKQPLMDKNRIEERLNLV 363

  Fly   636 GELI---RMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQ--K 695
            ...:   .:...|||  .||...||..| ||                         |.:.:|  .
  Rat   364 EAFVEDSELRQSLQE--DLLRRFPDLNR-LA-------------------------KKFQRQAAN 400

  Fly   696 LQGFMAVLKGFNDLTKLPTMF---------HQCKTTLLKRITQLPESGGSFPDLSKELQYFATAF 751
            ||....:.:|.|   :||.:.         ||. ..|...:|.|.:...   |.||..:...|..
  Rat   401 LQDCYRLYQGVN---QLPNVIQALEKYQGRHQA-LLLAVFVTPLTDLRS---DFSKFQEMIETTL 458

  Fly   752 DHDAAAKTGVIAPQAGMDAEYDAAMDSIGEV----EKRLKTYLVEQERHFG------------CR 800
            |.|.......:     :...:|..:..:.||    ||::::.|:...|..|            .:
  Rat   459 DMDQVENHEFL-----VKPSFDPNLSELREVMDGLEKKMQSTLISAARGLGLDPGKQIKLDSSAQ 518

  Fly   801 ITYFGSDKKRYQLDVPESHASKANKSY-TLEGQTKGKKPSRRYTTAETRAL----LKDMQHAEDT 860
            ..|:      :::...|....:.||:: |::.|..|.|    :|.:|..:|    .|:....|:.
  Rat   519 FGYY------FRVTCKEEKVLRNNKNFSTVDIQKNGVK----FTNSELSSLNEEYTKNKGEYEEA 573

  Fly   861 RNMVLKDLARRLFEKFSNHYDQWKQCI-DCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQ 924
            ::.::|::.     ..|:.|.:..|.: |.:|:||.:.|.|..:....|..|..::.:..:..|.
  Rat   574 QDAIVKEIV-----NISSGYVEPMQTLNDVLAHLDAVVSFAHVSNAAPVPYVRPVILEKGKGRII 633

  Fly   925 LEEGYHPCANAS---TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPA 986
            |:...|.|....   .:|||.:.. ...:....::||||||||||.:|:.|::|:|||||..:|.
  Rat   634 LKASRHACVEVQDDVAFIPNDVHF-EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPC 697

  Fly   987 ASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAI 1051
            .|..:|:||.|..|:||.|..|.|.|||:.|:.||:.||:.||..||:::|||||||:||||..:
  Rat   698 ESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGL 762

  Fly  1052 AASVVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTA 1115
            |.::..::| .:....:|:||:|.|.........:...|:..:.        |:||:|.||:...
  Rat   763 AWAISEYIATKIGAFCMFATHFHELTALASQIPTVNNLHVTALT--------TEETLTMLYQVKT 819

  Fly  1116 GACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAI-------------------ALQRKITAKIV 1161
            |.|.:|:|.:.|:||..|:.:|:.|.:.:.::|..                   .|:|:...||:
  Rat   820 GVCDQSFGIHVAELANFPRHVIECAKQKALELEEFQSIGTSQGHDETQPAAKRRCLEREQGEKII 884

  Fly  1162 AATAGNEDTKKEKINALKDL--------LKQLK 1186
            .     |...|.|.....||        |||||
  Rat   885 L-----EFLSKVKQVPFTDLSEESVSVKLKQLK 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	236/1006 (23%)
		MutS_I	263..375	CDD:279898	22/110 (20%)
		MutS_II	391..508	CDD:282973	24/122 (20%)
		MutS_III	584..>667	CDD:282977	26/93 (28%)
		MutS_IV	767..859	CDD:282975	20/112 (18%)
		ABC_MSH6_euk	924..1140	CDD:213253	82/219 (37%)
Msh2	NP_112320.2	MutS	26..853	CDD:223327	223/942 (24%)
Msh2	NP_112320.2	Interaction with EXO1. /evidence=ECO:0000250	601..671		15/70 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820