DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Msh6 and msh5

DIOPT Version :9

Sequence 1:NP_648755.1 Gene:Msh6 / 39654 FlyBaseID:FBgn0036486 Length:1190 Species:Drosophila melanogaster
Sequence 2:XP_005157849.1 Gene:msh5 / 570030 ZFINID:ZDB-GENE-131127-632 Length:814 Species:Danio rerio


Alignment Length:818 Identity:199/818 - (24%)
Similarity:334/818 - (40%) Gaps:213/818 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   389 QPNYMLAIVEKDEGTCSRYG---VCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVL------ 444
            |...:...:||.|..|..|.   |.|...:.|      .|..|.     .|:|.|:|:|      
Zfish    89 QEQCLARFLEKLESNCDEYKPEIVIFPSANFG------VEVSKQ-----RLISAHLPLLSSTITE 142

  Fly   445 ---FLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDN---W 503
               .|...|.:...:..:||:: ||:||          |         .|:...|...:||   .
Zfish   143 SEKILYISSCIPLDSGLMVRSI-GGLLK----------C---------VEKRRIGSELEDNDVGI 187

  Fly   504 PLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKP 568
            | :|:.:...:..:.....|.|. ||:        |.|.:|.|.||.:.                
Zfish   188 P-ILQFLTYTLQDVVYVDRDTYS-ALQ--------IFKSELHPSVLKLQ---------------- 226

  Fly   569 AVASTLRRSHMVLDATTLSNLRIIGEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQD 633
                              |.::   |..||...|:.|.:|:|..||..||..|:.|::::..||:
Zfish   227 ------------------SGVK---EGLSLYGILNQCRSKYGSLLLRQWLHRPTRDLNILNRRQE 270

  Fly   634 AIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGN--KQIKQMDHPDSRAILFEEKLYNKQKL 696
            .|             |...:|     ||.|.:....:  :.||.:.     .:|.:..|.| .|:
Zfish   271 VI-------------RFFTSP-----RNFADLCTLQSCLRSIKNIS-----MLLHKMSLCN-PKV 311

  Fly   697 QGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSK----ELQYFAT------AF 751
            ..:.::.|         |::  ....:...|..||:|...|.::|:    :|.|.||      .|
Zfish   312 AVWQSLYK---------TVY--SAVCIRDTIRSLPQSIQLFREISENFTDDLFYIATYISKVVDF 365

  Fly   752 DHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKR----LKTYLVE---------QERHFGCRITY 803
            :...:.....:.|.          :|.:.:.:||    |..:|.:         ..|...|.:.|
Zfish   366 EGSISENRFTVRPN----------VDPVIDEKKRRMMGLPDFLTDVARAELENLDPRFSTCSVIY 420

  Fly   804 ---FGSDKKRYQLDVPESHASKANKSYTLEG-----QTKGKKPSRRYTTAETRALLKDMQHAE-- 858
               .|     :.|.||...:....:|:.:.|     .:|.:...|...|.|..::|.|: |.:  
Zfish   421 MPLIG-----FLLTVPRLPSMLDKQSFEIAGLDFIFLSKDQLHYRSTRTKELDSMLGDL-HCDIL 479

  Fly   859 DTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFI 923
            |....|::.|...:.::....|.....|    |.||.|.:||: |.::...|.|.|.::..   :
Zfish   480 DLEMAVMRKLQASVLQRSDCMYKVMSLC----AELDCLIALAQ-ASREHGYCCPILTTEHR---L 536

  Fly   924 QLEEGYHP----CAN---ASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIG 981
            .|.|..||    |.:   ::|||      .:.:|..:.::||||..|||..:::|||:|.||.||
Zfish   537 ALIESRHPLLELCTSVFVSNTYI------SSETEGKVKVITGPNSSGKSIFLKQVGLIVFMALIG 595

  Fly   982 AHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATY 1046
            :::||....:.|||.||||:.:::.|..|.|||::::|:.:..|.|:|.:||||:||.|:||.|.
Zfish   596 SNVPAKEAEIGLVDGIFTRMHSRESISVGLSTFMIDVNQMAHSLNHSTENSLVLVDEFGKGTNTV 660

  Fly  1047 DGTAIAASVVN--FLANLKC-RTLFSTHYHNLID--FFHNDKRITLGHMACMVENEDNADPTQET 1106
            ||.::..|.::  ....|:| ..|.||.:|:||.  ...:...:.|..:...:|.::        
Zfish   661 DGLSLLVSCLSHWLRRGLQCPHLLMSTCFHSLIQLGLIPDSSLLALLTLETAIEGDE-------- 717

  Fly  1107 VTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELS 1144
            :.|||:...|.|..|...|.|.|||:|..:::|..|:|
Zfish   718 LVFLYQVKNGICQSSCAANIATLAGIPDDLVRRGVEVS 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msh6NP_648755.1 MttA_Hcf106 <44..156 CDD:294511
MutS 261..1186 CDD:223327 199/818 (24%)
MutS_I 263..375 CDD:279898
MutS_II 391..508 CDD:282973 29/131 (22%)
MutS_III 584..>667 CDD:282977 22/82 (27%)
MutS_IV 767..859 CDD:282975 21/114 (18%)
ABC_MSH6_euk 924..1140 CDD:213253 77/227 (34%)
msh5XP_005157849.1 MutS_III 206..360 CDD:282977 50/234 (21%)
MUTSd 234..549 CDD:214710 80/373 (21%)
P-loop_NTPase 538..743 CDD:304359 75/218 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0249
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138168at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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