DRSC/TRiP Functional Genomics Resources

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Protein Alignment Msh6 and Msh4

DIOPT Version :9

Sequence 1:NP_648755.1 Gene:Msh6 / 39654 FlyBaseID:FBgn0036486 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_114076.1 Gene:Msh4 / 55993 MGIID:1860077 Length:958 Species:Mus musculus


Alignment Length:887 Identity:201/887 - (22%)
Similarity:355/887 - (40%) Gaps:209/887 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   388 HQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSAL 452
            |.|:.::|:||.........|:..||.......|.:|.|:...::::|.:....|:..:...:|.
Mouse   174 HAPSVIVAVVEGRGLARGEIGMASIDLKSPQIMLSQFADNTTYAKVITKLQVLSPLEIIMSNTAC 238

  Fly   453 SQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSD---- 513
                               |.||      :.|...|:.|.:     .:.|:..|.|...::    
Mouse   239 -------------------VVGN------STKLFTLITENF-----KNVNFTTVQRKYFNETKGL 273

  Fly   514 --MDHLGLTPNDNYKL----------ALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADA 566
              ::.|.:....:..:          |..||.:.:.||......||.|.:    .:...:|.|  
Mouse   274 EYIEQLCIAEFSSVLMEVQSRYYCLAAAAALLKYVEFIQNSVYAPKSLKI----YFQGSEQTA-- 332

  Fly   567 KPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDV 625
                         ::|:::..||.::      ...|:|...|::..|..|.|.|...:..|..||
Mouse   333 -------------MIDSSSAQNLELLVNNQDYRSNHTLFGVLNYTKTAGGSRRLRSNILEPLVDV 384

  Fly   626 SVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKL 690
            ..|..|.|.:.||::.......::::::...|.|:.|:.:     .||.:.|..::.    |.|:
Mouse   385 ETISMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVL-----VQIPKQDTVNAA----ESKI 440

  Fly   691 YNKQKLQGFMAVLKGFNDLTK-LPTMFHQCKTTLLKRITQLPESGGSFPD--LSKELQYFATAFD 752
            .|       :..||...:|.: |......|.|.||:...      ||..|  ....|....|..:
Mouse   441 TN-------LIYLKHTLELVEPLKVTLKNCSTPLLRAYY------GSLEDHRFGLILDKIKTVIN 492

  Fly   753 HDAAAKTGVI--------APQAGMDAEYDAAM--------DSIGEVEKRLKTYLVEQERHFGCRI 801
            .||....|.:        |.::.:....|.|.        |..|.:.:..:.|.:.....|....
Mouse   493 DDARYMKGCLNMRTQKCYAVRSNISEFLDIARRTYTEIVDDIAGMIAQLAEKYSLPLRTSFSSSR 557

  Fly   802 TYF----------GSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQH 856
            .:|          .||    ||.......||...||:             :|:|:   |:|..:.
Mouse   558 GFFIQMTTDCAALSSD----QLPSEFIKISKVKNSYS-------------FTSAD---LIKMNER 602

  Fly   857 AEDTRN-------MVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPEL 914
            .:::..       |::..|...::|    |.....:..|.|:.||:|.|.|.       .|.   
Mouse   603 CQESLREIYHMTYMIVCKLLSEIYE----HIHCLYKLSDTVSMLDMLLSFAH-------ACT--- 653

  Fly   915 VSDADQP----FIQLEEGYH----------PCANASTYIPNGLELGTASEAPLSLLTGPNMGGKS 965
            :||..:|    .:.:::|:|          |.|| :|||..|        :.:.::|||||.|||
Mouse   654 LSDYVRPEFTDTLAIKQGWHPILEKISAEKPVAN-NTYITEG--------SNVLIITGPNMSGKS 709

  Fly   966 TLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATC 1030
            |.::::.|..||||||:::||......:..:||||:...|||....|||:.|:.|.:.||.:|..
Mouse   710 TYLKQIALCQIMAQIGSYVPAEYASFRIAAQIFTRISTDDDIETNSSTFMKEMKEIAYILHNAND 774

  Fly  1031 HSLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDK-RITLGHMACMV 1094
            .||:|:|||||||.|.:|..|:.:|...|.::|..|||:||:   ::..|.|. .:.:.:|...|
Mouse   775 KSLILIDELGRGTNTEEGIGISYAVCEHLLSIKAFTLFTTHF---LELCHLDALYLNVENMHFEV 836

  Fly  1095 ENEDNADPTQETVTFLYKYTAGAC-PKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRK--- 1155
            ::..|....::.:.:.||.:.|.. .|:||..||:.:.:|..|:..|.:::.::....||.:   
Mouse   837 QHVKNTSRNKDAILYTYKLSRGLTEEKNYGLKAAEASSLPSSIVLDARDITTQITRQILQNQRSS 901

  Fly  1156 -----------ITAKIVAATAGNEDTKKEKINALKDLLKQLK 1186
                       :..::|.| |.|...:.::   |:..|..||
Mouse   902 PEMDRQRAVYHLATRLVQA-ARNSQLEPDR---LRTYLSNLK 939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msh6NP_648755.1 MttA_Hcf106 <44..156 CDD:294511
MutS 261..1186 CDD:223327 199/885 (22%)
MutS_I 263..375 CDD:279898
MutS_II 391..508 CDD:282973 20/116 (17%)
MutS_III 584..>667 CDD:282977 20/88 (23%)
MutS_IV 767..859 CDD:282975 19/109 (17%)
ABC_MSH6_euk 924..1140 CDD:213253 78/227 (34%)
Msh4NP_114076.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..110
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..161
MutS_II 177..315 CDD:282973 27/167 (16%)
MutS_III 337..>422 CDD:282977 19/84 (23%)
MUTSd 356..678 CDD:214710 76/377 (20%)
MutS_IV 515..609 CDD:282975 19/113 (17%)
MutS_V 657..893 CDD:278891 80/247 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0249
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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