DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msh6 and msh4

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_009291531.1	Gene:	msh4 / 559917	ZFINID:	ZDB-GENE-131121-643	Length:	800	Species:	Danio rerio

Alignment Length:	885	Identity:	218/885 - (24%)
Similarity:	352/885 - (39%)	Gaps:	215/885 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 MLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMP--VLFLNEKSALSQR 455
            ::|:||.........|:..|:....:..|.:|.|....::::|.:.:..|  :|..:..|...|.
Zfish    18 IVAVVEGRGLARGEIGMASINMKYPELVLSQFVDTGTYTKVITKLHNLTPMEILMPDTASVKGQG 82

  Fly   456 TQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYY-AGPGSD-------DNWPLVLRTMQS 512
            |:      |..::.|..|         ..|...:..||: ...|.:       ..:..||..:|:
Zfish    83 TK------LYSLITETFP---------SVTFTAVLRRYFNEKKGLEFIQQLCVPEFTTVLMEVQT 132

  Fly   513 DMDHLGLTPNDNYKLA-LKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRR 576
            ..          |.|| ..||.:...|:.|....||.|.:.    :...:|.|
Zfish   133 KY----------YCLASASALLKYFEFVQKSIYAPKSLKVT----FSGSEQTA------------ 171

  Fly   577 SHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAI 635
               ::||.:.|||.::      ..||:|...|:|..|..|:|.|...:..|..:|..||.|||.|
Zfish   172 ---MIDAVSASNLELVVNHRNHRSEHTLFGVLNHTKTSGGERRLRSNILEPLLEVDTIKSRQDTI 233

  Fly   636 GELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFM 700
            .||::.......::..:|...|.:..|:        .:.|:...::.|:. |.|:....:|:..:
Zfish   234 QELLQNEELFFSLKNAIAHFLDIDELLS--------ALVQIPKQETIAVA-EAKITQVIQLKHIV 289

  Fly   701 AVLKGF-----NDLTKLPTMFHQCKT-------TLLKRITQLPESGGSF---------------- 737
            .::...     :..|.|.|.:  ||:       ::|..|..|.....|:
Zfish   290 ELVPSLKVMLQHSTTHLLTAY--CKSLEDCRFNSILDHIKSLINDDTSYMKGSLTMRTQKCYAVR 352

  Fly   738 PDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRIT 802
            |::|:.|.....|:       |.|:...||:.|:       :||
Zfish   353 PNVSEFLDIARRAY-------TEVVDDIAGLVAQ-------LGE--------------------- 382

  Fly   803 YFGSDKKRYQLDVPESHASKANKSYTLEGQT--KGKKPSR-----------RYTTAETRALLKDM 854
                 |....|....|:|........|||..  .||.|..           .:||.:   |:|..
Zfish   383 -----KHNLPLRTSFSNARGFFIQMKLEGGALPGGKLPDEFIKVSKQKNNFSFTTLD---LMKMN 439

  Fly   855 QHAEDTRNMVLKDLARRLF---EKFSNHYDQWKQCI----DCVANLDVLGSLAEYAGQQMVICV- 911
            .|.|:    .|||:....:   .|..|...:...|:    |.|:.||:|.|||.       .|.
Zfish   440 DHCEE----ALKDIFHMSYVVVSKLLNEVHEQIHCLYKLSDVVSMLDMLLSLAN-------ACTI 493

  Fly   912 -----PEL-----VSDADQPFIQLEEGYHPCANASTYIPNGLELGTASEAPLSLLTGPNMGGKST 966
                 ||.     :.....|.::...|..|.:| ::||..|        :...::|||||.||||
Zfish   494 SNYVRPEFTDTLAIQQGRHPVLERISGQQPISN-NSYISEG--------SNFVIITGPNMSGKST 549

  Fly   967 LMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCH 1031
            .:::|.|:.||||||..:||....:.:.|:||||:|..||.....|||:||:.|.|.|:.:||..
Zfish   550 FLKQVALVQIMAQIGCFVPAEYASVRIADQIFTRIGVDDDFETNSSTFMVEMKEVSYIIHNATNS 614

  Fly  1032 SLVLLDELGRGTATYDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVEN 1096
            ||:::|||||||:..:|..|..||..||.|||..|||:||:..|.........:...||  .|::
Zfish   615 SLIIIDELGRGTSPEEGIGICHSVCEFLINLKAFTLFATHFLELCQLQTLYPNVENQHM--QVQH 677

  Fly  1097 EDNADPTQETVTFLYKYTAG-ACPKSYGFNAAKLAGMPQGIIKRAYELSKKVE-----------A 1149
            ....|...|.|.:.|:.:.| :..::||..||::..:|..||:.|..::.|:.           |
Zfish   678 IRTGDGRAERVVYTYQLSRGHSEERNYGIRAAEMTNLPLDIIQEAKTVADKINQKLWAKHHSDPA 742

  Fly  1150 IALQR---KITAKIVAATAGNEDTKKEKINALKDLLKQLK 1186
            ...||   ::..::| .||.|....:.   :|:..||.||
Zfish   743 TLKQRADYRLATRLV-QTARNSQLDRA---SLRHYLKGLK 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	216/883 (24%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	22/124 (18%)
		MutS_III	584..>667	CDD:282977	25/88 (28%)
		MutS_IV	767..859	CDD:282975	19/104 (18%)
		ABC_MSH6_euk	924..1140	CDD:213253	82/216 (38%)
msh4	XP_009291531.1	MutS_II	17..153	CDD:282973	30/159 (19%)
		MutS_III	180..>261	CDD:282977	23/80 (29%)
		MUTSd	195..516	CDD:214710	79/385 (21%)
		MutS_IV	354..445	CDD:282975	26/137 (19%)
		MutS_V	496..732	CDD:278891	87/246 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820