DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and Msh3

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001178886.1	Gene:	Msh3 / 499505	RGDID:	1563954	Length:	1105	Species:	Rattus norvegicus

Alignment Length:	1279	Identity:	319/1279 - (24%)
Similarity:	517/1279 - (40%)	Gaps:	282/1279 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NTSVGGTP-TNTLLNYFSKSPAFDKKKLTPSVKTDPDASK-----SEKENLQNQQPKVKDGKKEA 64
            :.:.|..| ...:|:.|.||....:..::|   |:| |.|     |.|.:|.|.:|..|..||..
  Rat    11 SNAAGPDPGRQVVLSRFFKSAGSLRSSVSP---TEP-AEKVTEGDSRKRSLGNGEPTNKKAKKVP 71

  Fly    65 SKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSV 129
            .:......:...:.||       |:.::|..       |:||.:...:...|....:|....:::
  Rat    72 EEEGENTSVASHNPEP-------KKCLRPRI-------VSKSLEKLKEFCCDSALPQNRVQTEAL 122

  Fly   130 SSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKNL 194
            .... .|.|...|..                               :.|:|.|:.|...|..|:
  Rat   123 WERL-AVLPKCTDFE-------------------------------DITLQRAKNAVLSEDSKS- 154

  Fly   195 QSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLN 259
            |:|.| |..:.           |.....||....:|...:.|             :::.|.:.
  Rat   155 QANQK-DTQFG-----------PSPEAFQKTSTCKPFNRRSK-------------SIYTPLEL-- 192

  Fly   260 GLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELG-FTYMRGEFAHSGFPEISFDK 323
                   |:..:|..:.|.||..:.|..|..:..||::...||. :.::...|..:..|......
  Rat   193 -------QYLDVKQLHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFV 250

  Fly   324 MSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNH 388
            ....||.:|:||..|:||||..:     |.|...| ..|.:|::       |.::.....||.:.
  Rat   251 HVRRLVAKGYKVGVVKQTETAAL-----KAIGDNK-SSVFSRKL-------TALYTKSTLIGEDV 302

  Fly   389 QP-------------------NYMLAIVE-------KDEGTCSRYGVCFIDTSIGDFHLGEFEDD 427
            .|                   ||:|.|.|       |.:|..| :|:..:..:.|:.....|:|.
  Rat   303 NPLIRLDDSVNIDEAVTDTSTNYLLCIYEEKENIKDKKKGNIS-FGIVGVQPATGEVVFDCFQDS 366

  Fly   428 KNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLG------GILKEPVPGNGKHACSAEKTL 486
            .:...|.|..:...||..| ..|.||:.|:.::|....      .|..|.:.........|.:|:
  Rat   367 ASRLELETRTASLQPVELL-LPSQLSEPTEMLIRRATAVSVGDDRIRVERMNNTHFEYSHAFQTV 430

  Fly   487 KLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPM 551
            .    .:||....|......|    |.:.||       .|..:.||...|.::.:..|: |||
  Rat   431 M----EFYARETVDTQGSQSL----SGVIHL-------EKPVICALAAIIRYLKEFNLD-KVL-- 477

  Fly   552 ARYQLYVPPDQLADAKPAVASTLR--RSHMVLDATTLSNLRIIGEE------HSLLSTLDHCCTK 608
                          :||.....|.  ...|.::.|||.||.|:..:      .|||..|||..|.
  Rat   478 --------------SKPENFKQLSSGMEFMRINGTTLRNLEILQNQTDMKTRGSLLWVLDHTKTS 528

  Fly   609 FGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTEL-QEVRALLAPMPDFERNLAQIHLFGNKQ 672
            ||:|.|..|:..|...:..|..|.|||.:::...:.: :::..||..:||.||.|..|:
  Rat   529 FGRRKLKKWVTQPLLKLRDINARLDAISDVLHSESSVFEQIENLLRKLPDVERGLCSIY------ 587

  Fly   673 IKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTK-----LPTMFHQCKTTLLK-RITQLP 731
                              :.|...|.|..::|....|..     :|.:....::.||: |:.::|
  Rat   588 ------------------HKKCSTQEFFLIVKNLCQLKSELQALMPAVNSHVQSDLLRARVLEVP 634

  Fly   732 ESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKR----------L 786
            |       |...::.:....:..||        :||...|....:.....::||          :
  Rat   635 E-------LLSPVEPYLKVLNEQAA--------KAGDKTELFKDLSDFPLIKKRKNEIQEVIHSI 684

  Fly   787 KTYLVEQERHFGC-RITYFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRAL 850
            :.:|.|..:.... .:.|.....:.:.:::..|..|.....:...|.||...........|....
  Rat   685 QMHLQELRKILKLPSLQYVTVSGQEFMVEIKNSAVSCVPTDWVKVGSTKAVSRFHSPFVVENYRR 749

  Fly   851 LKDMQHAEDTRNMVLKDLARRL--FEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPE 913
            |..::     ..:||...|..|  .|.|..||....:.:|.:|.:|.:.|||:.| :|...|.|.
  Rat   750 LNQLR-----EQLVLDCNAEWLDFLENFGEHYHTLCKAVDHLATVDCIFSLAKVA-KQGSYCRPT 808

  Fly   914 LVSDADQPFIQLEEGYHPCANA-----STYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGL 973
            |   .::..|.::.|.||..:.     ..::||...|...||. :.::|||||||||:.:::|.|
  Rat   809 L---QEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTNLSQDSER-VMIITGPNMGGKSSYIKQVAL 869

  Fly   974 LVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDE 1038
            :|||||||:::||....:.:||.||||.||.|:|..|.|||:.||.:|:.|::.||..|||:|||
  Rat   870 VVIMAQIGSYVPAEEATIGIVDGIFTRRGAADNIYKGRSTFMEELTDTAEIIQKATQRSLVILDE 934

  Fly  1039 LGRGTATYDGTAIA-ASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRI--TLG--HMACMV---- 1094
            |||||:|:||.||| |::..|:.::|..|||.|||..:.:.   :||.  .:|  ||..:|
  Rat   935 LGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCEL---EKRYPEQVGNYHMGFLVNEDG 996

  Fly  1095 ENEDNADPTQ--ETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIA-LQRKI 1156
            ..:|:.|..|  ::|||||:.|.|...:|||.|.||||.:|:.|:::|...||::|.:. |:||.
  Rat   997 SKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREILQKAAHKSKELEGLVNLRRKR 1061

  Fly  1157 TAKIV--------------AATAGNEDTKKEKINALKDLLKQLK 1186
            ....:              ||....::.:....|.:|..|.:||
  Rat  1062 LEYFIDLWTTHSVKDLHTRAAELEIQEIQTSPHNEMKTTLLELK 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	21/116 (18%)
		MutS	261..1186	CDD:223327	270/1016 (27%)
		MutS_I	263..375	CDD:279898	28/112 (25%)
		MutS_II	391..508	CDD:282973	29/129 (22%)
		MutS_III	584..>667	CDD:282977	32/89 (36%)
		MutS_IV	767..859	CDD:282975	14/102 (14%)
		ABC_MSH6_euk	924..1140	CDD:213253	100/231 (43%)
Msh3	NP_001178886.1	MutS	183..1053	CDD:223327	263/990 (27%)
		MutS_I	188..301	CDD:279898	32/134 (24%)
		MutS_II	324..481	CDD:282973	42/190 (22%)
		MutS_III	498..>613	CDD:282977	37/138 (27%)
		MutS_III	670..741	CDD:302670	10/70 (14%)
		MutS_V	804..1052	CDD:278891	107/254 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930