DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msh6 and MSH5

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_751897.1	Gene:	MSH5 / 4439	HGNCID:	7328	Length:	835	Species:	Homo sapiens

Alignment Length:	952	Identity:	225/952 - (23%)
Similarity:	378/952 - (39%)	Gaps:	244/952 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 AHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQ 376
            |.||||       |...|. |.:.|..|:.|..:.:.|               ..:|.:.|.|
Human    20 ASSGFP-------SPAPVP-GPREAEEEEVEEEEELAE---------------IHLCVLWNSG-- 59

  Fly   377 VFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHM 441
                           |:              |:.:.|||....|......|....:||..|...
Human    60 ---------------YL--------------GIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDE- 94

  Fly   442 PVLFLNEKSALSQRTQQIVRTVLGGIL-----KEPVPGNGKHACSAEKTLKLLAERYYAGPGSDD 501
                :|.:|.::...|....|...|.|     :||.........|.:..|::..:|..:|
Human    95 ----INPQSVVTSAKQDENMTRFLGKLASQEHREPKRPEIIFLPSVDFGLEISKQRLLSG----- 150

  Fly   502 NWPLVLRTMQSDMDHLGLT---PNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQL 563
            |:..:...|.:....|.|:   |.| ..|.::|||..:.|:.:.::.   :.:..|.:.||   :
Human   151 NYSFIPDAMTATEKILFLSSIIPFD-CLLTVRALGGLLKFLGRRRIG---VELEDYNVSVP---I 208

  Fly   564 ADAKPAVASTLRRSHMV-LDATTLSNLRII-GEEH--------------SLLSTLDHCCTKFGKR 612
            ...|..:.     :|:| :|..|.|.|:|. .|.|              ||...|:.|..|:|::
Human   209 LGFKKFML-----THLVNIDQDTYSVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEK 268

  Fly   613 LLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQI--HLFGNKQIKQ 675
            ||..|...|:.|:..:..|.|.| :...:|..|               ::||:  .|.|:  ||.
Human   269 LLRLWFTRPTHDLGELSSRLDVI-QFFLLPQNL---------------DMAQMLHRLLGH--IKN 315

  Fly   676 MDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDL 740
            :.....|..|...|:.:.|.|...:....|..|         .|::        ||:|...|.|:
Human   316 VPLILKRMKLSHTKVSDWQVLYKTVYSALGLRD---------ACRS--------LPQSIQLFRDI 363

  Fly   741 SKE----LQYFATA------FDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKR---LKTYLVE 792
            ::|    |.:.|:.      |:...|.....:.|  .:|.|.|       |.::|   |.::|.|
Human   364 AQEFSDDLHHIASLIGKVVDFEGSLAENRFTVLP--NIDPEID-------EKKRRLMGLPSFLTE 419

  Fly   793 ---------QERHFGCRITY---FGSDKKRYQLDVPESHASKANKSYTLEG-----QTKGKKPSR 840
                     ..|...|.:.|   .|     :.|.:|...:......:.:.|     .::.|...|
Human   420 VARKELENLDSRIPSCSVIYIPLIG-----FLLSIPRLPSMVEASDFEINGLDFMFLSEEKLHYR 479

  Fly   841 RYTTAETRALLKDMQHAE--DTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYA 903
            ...|.|..|||.|: |.|  |...:::..|..::..:.:    ...:.:|..:.||||.:||..|
Human   480 SARTKELDALLGDL-HCEIRDQETLLMYQLQCQVLARAA----VLTRVLDLASRLDVLLALASAA 539

  Fly   904 ---GQQMVICVPELVSDADQPFIQLEEGYHP----CANASTYIPNGLELGTASEAPLSLLTGPNM 961
               |.......|:::.      ::::.|.||    ||.  |::||..|.| ..:..:.::||||.
Human   540 RDYGYSRPRYSPQVLG------VRIQNGRHPLMELCAR--TFVPNSTECG-GDKGRVKVITGPNS 595

  Fly   962 GGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELN-ETSLIL 1025
            .|||..:::|||:..||.:|:.:||....:..||.||||:.:.:.|..|.|||:::|| :.:..:
Human   596 SGKSIYLKQVGLITFMALVGSFVPAEEAEIGAVDAIFTRIHSCESISLGLSTFMIDLNQQVAKAV 660

  Fly  1026 KHATCHSLVLLDELGRGTATYDGTAIAASVV-NFLA-NLKCRTLF-STHYHNLIDFFHNDKRITL 1087
            .:||..||||:||.|:||.|.||.|:.|:|: ::|| ...|..:| :|::.:|:..    :.:..
Human   661 NNATAQSLVLIDEFGKGTNTVDGLALLAAVLRHWLARGPTCPHIFVATNFLSLVQL----QLLPQ 721

  Fly  1088 GHMA---CMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEA 1149
            |.:.   .|...||..|     :.|.|:...|....|:..:.|..||:|..::.|..|:|..:.:
Human   722 GPLVQYLTMETCEDGND-----LVFFYQVCEGVAKASHASHTAAQAGLPDKLVARGKEVSDLIRS 781

  Fly  1150 IALQRKITAKIVAATAGNEDTKKEKINALKDLLK--QLKMCQ 1189
                                  .:.|..:|||||  |::.||
Human   782 ----------------------GKPIKPVKDLLKKNQMENCQ 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	223/947 (24%)
		MutS_I	263..375	CDD:279898	14/62 (23%)
		MutS_II	391..508	CDD:282973	23/121 (19%)
		MutS_III	584..>667	CDD:282977	24/99 (24%)
		MutS_IV	767..859	CDD:282975	25/113 (22%)
		ABC_MSH6_euk	924..1140	CDD:213253	74/226 (33%)
MSH5	NP_751897.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		11/31 (35%)
		MutS	129..814	CDD:223327	192/784 (24%)
		ABC_MSH5_euk	557..764	CDD:213248	72/218 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820