DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msh6 and MSH4

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_002431.2	Gene:	MSH4 / 4438	HGNCID:	7327	Length:	936	Species:	Homo sapiens

Alignment Length:	873	Identity:	199/873 - (22%)
Similarity:	359/873 - (41%)	Gaps:	177/873 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 HQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMP--VLFLNEKS 450
            |.|:.::|:||.........|:..||.......|.:|.|:...::::|.:....|  ::..|...
Human   152 HSPSVIVAVVEGRGLARGEIGMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNTAC 216

  Fly   451 ALSQRTQQIVRTVLGGILKEPVPGNGKHA---------CSAEKTLKLLAERYYAGPGSDDNWPLV 506
            |:...|:      |..::.|    |.|:.         .:..|.|:.:.:...|      .:..|
Human   217 AVGNSTK------LFTLITE----NFKNVNFTTIQRKYFNETKGLEYIEQLCIA------EFSTV 265

  Fly   507 LRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVA 571
            |..:||....|.         |:.||.:.:.||......||.|.:.    :...:|.|
Human   266 LMEVQSKYYCLA---------AVAALLKYVEFIQNSVYAPKSLKIC----FQGSEQTA------- 310

  Fly   572 STLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKE 630
                    ::|:::..||.::      ...|:|...|::..|..|.|.|...:..|..|:..|..
Human   311 --------MIDSSSAQNLELLINNQDYRNNHTLFGVLNYTKTPGGSRRLRSNILEPLVDIETINM 367

  Fly   631 RQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQK 695
            |.|.:.||::.......::::::...|.|:.|:.:     .||.:.|..::........:|.|..
Human   368 RLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVL-----VQIPKQDTVNAAESKITNLIYLKHT 427

  Fly   696 LQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPD--LSKELQYFATAFDHDAAAK 758
            |:          .:..|......|.|.||:...      ||..|  ....|:...|..:.||...
Human   428 LE----------LVDPLKIAMKNCNTPLLRAYY------GSLEDKRFGIILEKIKTVINDDARYM 476

  Fly   759 TGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKA 823
            .|.:..:........:.::...::.:|..|.:|:.   ....|:..|   ::|.|.:..|.:|.
Human   477 KGCLNMRTQKCYAVRSNINEFLDIARRTYTEIVDD---IAGMISQLG---EKYSLPLRTSFSSA- 534

  Fly   824 NKSYTLEGQT-----------------KGKKPSRRYTTAETRALLKDMQHAEDTRN-------MV 864
             :.:.::..|                 ...|.|..:|:|:   |:|..:..:::..       |:
Human   535 -RGFFIQMTTDCIALPSDQLPSEFIKISKVKNSYSFTSAD---LIKMNERCQESLREIYHMTYMI 595

  Fly   865 LKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQP----FIQL 925
            :..|...::|    |.....:..|.|:.||:|.|.|.       .|.   :||..:|    .:.:
Human   596 VCKLLSEIYE----HIHCLYKLSDTVSMLDMLLSFAH-------ACT---LSDYVRPEFTDTLAI 646

  Fly   926 EEGYH----------PCANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQI 980
            ::|:|          |.|| :||:..|        :...::|||||.||||.::::.|..|||||
Human   647 KQGWHPILEKISAEKPIAN-NTYVTEG--------SNFLIITGPNMSGKSTYLKQIALCQIMAQI 702

  Fly   981 GAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTAT 1045
            |:::||......:..:||||:...|||....|||:.|:.|.:.||.:|...||:|:|||||||.|
Human   703 GSYVPAEYSSFRIAKQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNT 767

  Fly  1046 YDGTAIAASVVNFLANLKCRTLFSTHYHNLIDFFHNDKRI-TLGHMACMVENEDNADPTQETVTF 1109
            .:|..|..:|..:|.:||..|||:||:   ::..|.|... .:.:|...|::..|....:|.:.:
Human   768 EEGIGICYAVCEYLLSLKAFTLFATHF---LELCHIDALYPNVENMHFEVQHVKNTSRNKEAILY 829

  Fly  1110 LYKYTAGAC-PKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRK--------------ITAK 1159
            .||.:.|.. .|:||..||:::.:|..|:..|.|::.::....||.:              :..:
Human   830 TYKLSKGLTEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATR 894

  Fly  1160 IVAATAGNEDTKKEKINA-LKDLLKQLK 1186
            :| .||.|.....:.:.. |.:|.|:.|
Human   895 LV-QTARNSQLDPDSLRIYLSNLKKKYK 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	198/871 (23%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	22/127 (17%)
		MutS_III	584..>667	CDD:282977	19/88 (22%)
		MutS_IV	767..859	CDD:282975	16/108 (15%)
		ABC_MSH6_euk	924..1140	CDD:213253	79/227 (35%)
MSH4	NP_002431.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..133
		MutS_II	156..293	CDD:282973	31/161 (19%)
		MutS_III	315..>400	CDD:282977	18/84 (21%)
		MUTSd	334..656	CDD:214710	68/367 (19%)
		MutS_IV	493..587	CDD:282975	16/104 (15%)
		MutS_V	635..871	CDD:278891	82/247 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820