DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Msh6 and MSH3

DIOPT Version :9

Sequence 1:NP_648755.1 Gene:Msh6 / 39654 FlyBaseID:FBgn0036486 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_002430.3 Gene:MSH3 / 4437 HGNCID:7326 Length:1137 Species:Homo sapiens


Alignment Length:1240 Identity:303/1240 - (24%)
Similarity:510/1240 - (41%) Gaps:267/1240 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 SPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRK 88
            :||| ..:|.|.:.|:.|..|  |..|:|..|..|..||...|..       ..|...||..:.|
Human    68 APAF-PPQLPPHIATEIDRRK--KRPLENDGPVKKKVKKVQQKEG-------GSDLGMSGNSEPK 122

  Fly    89 RIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSGAEEVSPSENDMSVDSPTPKKS 153
            :.::..:       |:||.:...:...|....::....:|:.. ...|.|...|....|      
Human   123 KCLRTRN-------VSKSLEKLKEFCCDSALPQSRVQTESLQE-RFAVLPKCTDFDDIS------ 173

  Fly   154 RKKSKILNNNN--NNEPSSKKVKLEST--IQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNL 214
                 :|:..|  ::|.|.:::..:.|  ..|::..:.....:|||..|.:.|          |.
Human   174 -----LLHAKNAVSSEDSKRQINQKDTTLFDLSQFGSSNTSHENLQKTASKSA----------NK 223

  Fly   215 DEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCV 279
            ....::...:|::::                                         :|..:.|.|
Human   224 RSKSIYTPLELQYIE-----------------------------------------MKQQHKDAV 247

  Fly   280 LFFKVGKFYELYHMDADVGVNELG-FTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTET 343
            |..:.|..|..:..||::...||. :.::...|..:..|..........||.:|:||..|:||||
Human   248 LCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTET 312

  Fly   344 PDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQP------------------ 390
            ..:     |.|...: ..:.:|::       |.::.....||.:..|                  
Human   313 AAL-----KAIGDNR-SSLFSRKL-------TALYTKSTLIGEDVNPLIKLDDAVNVDEIMTDTS 364

  Fly   391 -NYMLAIVEKDEGTCSR------YGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNE 448
             :|:|.|.|..|....:      .|:..:..:.|:.....|:|..:.|.|.|.:|...||..| .
Human   365 TSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELL-L 428

  Fly   449 KSALSQRTQQIVRTVLGGILKEP---------VPGNGKHACSAEKTLKLLAERYYAGPGSDDNWP 504
            .||||::|:.::.......:::.         :.....||..|       ...:||....|....
Human   429 PSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQA-------VTEFYAKDTVDIKGS 486

  Fly   505 LVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPA 569
            .::    |.:.:|       .|..:.:|...|.::.:..|| |:|                :||.
Human   487 QII----SGIVNL-------EKPVICSLAAIIKYLKEFNLE-KML----------------SKPE 523

  Fly   570 VASTL--RRSHMVLDATTLSNLRIIGEE------HSLLSTLDHCCTKFGKRLLHHWLCAPSCDVS 626
            ....|  :...|.::.|||.||.|:..:      .|||..|||..|.||:|.|..|:..|...:.
Human   524 NFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLR 588

  Fly   627 VIKERQDAIGELIRMPTEL-QEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKL 690
            .|..|.||:.|::...:.: .::...|..:||.||.|..|:                        
Human   589 EINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIY------------------------ 629

  Fly   691 YNKQKLQGFMAVLKGFNDLTK-----LPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATA 750
            :.|...|.|..::|....|..     :|.:....::.||:.:..      ..|:|...::::...
Human   630 HKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVIL------EIPELLSPVEHYLKI 688

  Fly   751 FDHDAAA---KTGVIAPQAGMDA------EYDAAMDSI----GEVEKRLKTYLVEQERHFGCRIT 802
            .:..||.   ||.:....:....      |....:|.|    .|:.|.||....:.       :|
Human   689 LNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQY-------VT 746

  Fly   803 YFGSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKD 867
            ..|.:   :.:::..|..|.....:...|.||.  .||.::.    .::::.:|....|..::.|
Human   747 VSGQE---FMIEIKNSAVSCIPTDWVKVGSTKA--VSRFHSP----FIVENYRHLNQLREQLVLD 802

  Fly   868 LARR---LFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGY 929
            .:..   ..||||.||....:.:..:|.:|.:.|||:.| :|...|.|.:   .::..|.::.|.
Human   803 CSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVA-KQGDYCRPTV---QEERKIVIKNGR 863

  Fly   930 HPCANA-----STYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASC 989
            ||..:.     ..|:||..:|...||. :.::|||||||||:.:::|.|:.||||||:::||...
Human   864 HPVIDVLLGEQDQYVPNNTDLSEDSER-VMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEA 927

  Fly   990 RLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIA-A 1053
            .:.:||.||||:||.|:|..|.|||:.||.:|:.|::.||..|||:||||||||:|:||.||| |
Human   928 TIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYA 992

  Fly  1054 SVVNFLANLKCRTLFSTHYHNLIDFFHN-DKRITLGHMACMV-ENEDNADP-----TQETVTFLY 1111
            ::..|:.::|..|||.|||..:.:...| ..::...||..:| |:|...||     ..:.|||||
Human   993 TLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLY 1057

  Fly  1112 KYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAA--TAGN-EDTKK- 1172
            :.|.|...:|||.|.||||.:|..|:|:|...||::|.:...::...|..|.  |..| :|.:| 
Human  1058 QITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKW 1122

  Fly  1173 -EKIN 1176
             |:.|
Human  1123 TEEFN 1127

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msh6NP_648755.1 MttA_Hcf106 <44..156 CDD:294511 22/111 (20%)
MutS 261..1186 CDD:223327 261/999 (26%)
MutS_I 263..375 CDD:279898 25/112 (22%)
MutS_II 391..508 CDD:282973 27/131 (21%)
MutS_III 584..>667 CDD:282977 31/89 (35%)
MutS_IV 767..859 CDD:282975 17/101 (17%)
ABC_MSH6_euk 924..1140 CDD:213253 100/228 (44%)
MSH3NP_002430.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..122 19/63 (30%)
Interaction with EXO1. /evidence=ECO:0000269|PubMed:11427529 75..297 51/300 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..222 5/30 (17%)
MutS 225..1111 CDD:223327 256/1026 (25%)
MutS_I 230..343 CDD:279898 29/166 (17%)
MutS_II 366..523 CDD:282973 37/192 (19%)
MutS_III 540..680 CDD:282977 41/169 (24%)
MutS_III 717..783 CDD:302670 16/77 (21%)
MutS_V 846..1094 CDD:278891 106/251 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0249
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53698
OrthoDB 1 1.010 - - D138168at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.830

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