DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msh6 and msh2

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_998689.1	Gene:	msh2 / 406845	ZFINID:	ZDB-GENE-040426-2932	Length:	936	Species:	Danio rerio

Alignment Length:	871	Identity:	218/871 - (25%)
Similarity:	349/871 - (40%)	Gaps:	214/871 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 GVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMP---VLFLNEKSALSQRTQQIVRTVLGGILK 469
            ||.::|:::....:.||.|:...|.|..|:....|   ||...:......:.:|:|:.  ||||
Zfish   162 GVGYVDSTLRKLGVCEFPDNDQFSNLEALLVQIGPKECVLPAGDSGGDQGKLKQVVQR--GGIL- 223

  Fly   470 EPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQ 534
              :....|    :|.|.|.:.:        |.|  .:|:..:.:.......|....|:|:..|..
Zfish   224 --LTDRKK----SEFTTKDIVQ--------DLN--RLLKARKGETVSSAALPEMEKKIAMSCLEA 272

  Fly   535 CIFFIHKCKLEPKV--LPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRII-GEE- 595
            .|.::.....|...  ..|..:.|                   ..:|.||...:..|.:. |..
Zfish   273 VIKYLELLADEANFGSFKMTTFDL-------------------NQYMRLDNAAVQALNLFQGSSD 318

  Fly   596 -----HSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRA----- 650
                 |||...|:.|.|..|:||::.|:..|..|.:.|:||.|    |:....|..|:|.
Zfish   319 DATGTHSLAGLLNKCRTPQGQRLVNQWIKQPLIDKNKIEERLD----LVETFVEDSELRKSCQED 379

  Fly   651 LLAPMPDFER----------NLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKG 705
            ||...||..|          ||...:     ::.|........:|..|:...|.::....|.:..
Zfish   380 LLRRFPDLNRMAKKFQRQSSNLQDCY-----RVYQSVGQLPNVVLALERYSGKHQVLLHAAFISP 439

  Fly   706 FNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFD------HDAAAKTGVIAP 764
            .|||                           ..|.||..:...|..|      |:...|
Zfish   440 LNDL---------------------------ISDFSKFQEMIETTLDMNQVEHHEFLVK------ 471

  Fly   765 QAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFG------------CRITYFGSDKKRYQLDVPE 817
             ...|.......:::..:||.::..|....|..|            .:|.||      :::...|
Zfish   472 -PSFDPTLSDLRENMDRLEKAMQAALSSAARELGLEAAKTVKLESNAQIGYF------FRVTCKE 529

  Fly   818 SHASKANKSY-TLEGQTKGKKPSRRYTTAETRAL----LKDMQHAEDTRNMVLKDLARRLFEKFS 877
            ..:.:.||.: ||:.|..|.    |:|.::..:|    .|..:..|:.:|.::|:    :....:
Zfish   530 EKSLRNNKKFTTLDVQKNGV----RFTNSKLSSLNEEYTKSREEYEEAQNAIVKE----IISIAA 586

  Fly   878 NHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSD-ADQPFIQ---LEEG---------Y 929
            .:.|..:...:.:|.||.:.|.|             :||. |..|||:   ||:|         .
Zfish   587 GYVDPVQTLNEVIAQLDAVLSFA-------------VVSHAAPVPFIRPKILEKGSGRLVLKAAR 638

  Fly   930 HPCANAS---TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRL 991
            |||..|.   .:|||.:.. ...|....::|||:||||||.:|:||::|:|||||..:|.....|
Zfish   639 HPCVEAQDEVAFIPNDVTF-IRGEKMFHIITGPSMGGKSTYIRQVGVIVLMAQIGCFVPCDEAEL 702

  Fly   992 SLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVV 1056
            |:||.:..|:||.|..:.|.|||:.|:.||:.||:.||..||:.:|||||||:||||..:|.::.
Zfish   703 SVVDCVLARVGAGDSQIKGVSTFMAEMLETAAILRSATEDSLITIDELGRGTSTYDGFGLAWAIS 767

  Fly  1057 NFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPK 1120
            .::| .||...||:||:|.|.........:...|:..:.        |..|:|.|||...|.|.:
Zfish   768 EYIATRLKSFCLFATHFHELTALAQQVPTVRNLHVTALT--------TDSTLTMLYKVKKGVCDQ 824

  Fly  1121 SYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKK-------EKI--- 1175
            |:|.:.|:||..|:.:|..|.|     :|:.|:.......|...||.:..|:       |:|
Zfish   825 SFGIHVAELASFPKHVIANARE-----KALELEEFQDISSVGEEAGPKAKKRCMEKQEGERIIEA 884

  Fly  1176 ---------------NALKDLLKQLK 1186
                           .|:|:.|::||
Zfish   885 FLAKVKSMPVDGMSDKAVKEELRKLK 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	216/869 (25%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	24/102 (24%)
		MutS_III	584..>667	CDD:282977	29/104 (28%)
		MutS_IV	767..859	CDD:282975	20/108 (19%)
		ABC_MSH6_euk	924..1140	CDD:213253	88/231 (38%)
msh2	NP_998689.1	MutS_I	17..129	CDD:279898
		MutS	23..911	CDD:223327	218/871 (25%)
		MutS_II	158..283	CDD:282973	30/139 (22%)
		MutS_III	305..>423	CDD:282977	31/126 (25%)
		MutS_IV	473..569	CDD:282975	20/105 (19%)
		ABC_MSH2_euk	633..852	CDD:213252	88/232 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820